The Relationship of Intracellular Iron Chelation to the Inhibition and Regeneration of Human Ribonucleotide Reductase

The depletion of cellular iron can lead to the inhibition of ribonucleotide reductase, preventing new DNA synthesis and hence inhibiting cell proliferation. Electron paramagnetic resonance (EPR) spectroscopy has been used to examine simultaneously for the first time the relationship between chelatio...

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Veröffentlicht in:	The Journal of biological chemistry 1996-08, Vol.271 (34), p.20291-20299
Hauptverfasser:	Cooper, Chris E., Lynagh, Gayle R., Hoyes, Katharine P., Hider, Robert C., Cammack, Richard, Porter, John B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Deferoxamine - chemistry Electron Spin Resonance Spectroscopy Humans Iron - metabolism Iron Chelating Agents - chemistry Pyridones - chemistry Ribonucleotide Reductases - antagonists & inhibitors Solubility Tumor Cells, Cultured Tyrosine - chemistry
Online-Zugang:	Volltext
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