Activation of Keratinocyte Nicotinic Cholinergic Receptors Stimulates Calcium Influx and Enhances Cell Differentiation

Human epidermal keratinocytes synthesize, secrete, and degrade acetylcholine and use their cell-surface nicotinic and muscarinic cholinergic receptors to mediate the autocrine and paracrine effects of acetylcholine. Because acetylcholine modulates transmembrane Ca2+ transport and intracellular metab...

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Veröffentlicht in:	Journal of investigative dermatology 1996-09, Vol.107 (3), p.412-418
Hauptverfasser:	Grando, Sergei A., Horton, Robert M., Mauro, Theodora M., Kist, David A., Lee, Tou X., Dahl, Mark V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology acetylcholine receptors Calcium - metabolism Calcium Channels - physiology Cell Differentiation - drug effects Electrophysiology Humans immunoblotting immunocytochemistry Ion Channel Gating Ion Channels - metabolism keratinocyte differentiation markers Keratinocytes - cytology Keratinocytes - metabolism Mecamylamine - pharmacology Nicotine - metabolism Nicotine - pharmacology Permeability Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism
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