Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene

Up to 7% of Caucasians may demonstrate ultrarapid metabolism of debrisoquine due to inheritance of alleles with duplicated functional CYP2D6 genes. Here we describe the genomic organization of the duplicated CYP2D6 genes in the 42 kb XbaI allele. We postulate that this duplication originates from a...

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Veröffentlicht in:	FEBS letters 1996-08, Vol.392 (1), p.30-34
Hauptverfasser:	Løvlie, Roger, Daly, Ann K., Molven, Anders, Idle, Jeffrey R., Steen, Vidar M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence Crossing Over, Genetic CYP CYP2D6 genotyping Cytochrome P-450 CYP2D6 Cytochrome P-450 Enzyme System - genetics cytochrome P450 Debrisoquin - metabolism Debrisoquine 4-hydroxylase DNA Gene duplication Humans Long-PCR metabolic ratio Mixed Function Oxygenases - genetics Molecular Sequence Data Multigene Family Polymerase Chain Reaction - methods poor metabolizer restriction fragment length polymorphism RFLP Ultrarapid metabolizer
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