Delineation of Transmembrane Domains of the Na+/H+ Exchanger That Confer Sensitivity to Pharmacological Antagonists

Plasma membrane Na+/H+ exchanger (NHE) isoforms NHE1 and NHE3 exhibit very different sensitivities to amiloride and its 5-amino-substituted analogues, benzoyl guanidinium derivatives (e.g. (3-methylsulfonyl-4-piperidinobenzoyl)guanidine methanesulfonate (HOE694)), and cimetidine. To define structura...

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Veröffentlicht in:	The Journal of biological chemistry 1996-08, Vol.271 (33), p.19922-19927
Hauptverfasser:	Orlowski, John, Kandasamy, Ramani A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiloride - analogs & derivatives Amiloride - pharmacology Animals Biological Transport Cimetidine - pharmacology DNA, Complementary - genetics Enzyme Inhibitors - pharmacology Guanidines - pharmacology Kinetics Ligands Membrane Glycoproteins - chemistry Rats Recombinant Fusion Proteins Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - antagonists & inhibitors Structure-Activity Relationship Sulfones - pharmacology
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