Ontogenetic Development of 5-HT1D Receptors in Human Brain: An Autoradiographic Study
The pattern of pre‐ and postnatal appearance of 5‐HT1D receptors throughout the different areas of the human brain was studied by quantitative in vitro autoradiography, using [125I]GTI (serotonin O‐carboxymethyl‐glycyl‐[125I]tyrosinamide) as a ligand. The anatomical distribution of 5‐HT1D receptors...
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| Veröffentlicht in: | The European journal of neuroscience 1996-01, Vol.8 (1), p.53-60 |
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| creator | del Olmo, Elena del Arco, Carmen Díaz, Alvaro Pascual, Julio Mengod, Guadalupe Palacios, José M. Pazos, Angel |
| description | The pattern of pre‐ and postnatal appearance of 5‐HT1D receptors throughout the different areas of the human brain was studied by quantitative in vitro autoradiography, using [125I]GTI (serotonin O‐carboxymethyl‐glycyl‐[125I]tyrosinamide) as a ligand. The anatomical distribution of 5‐HT1D receptors in neonatal, infant and children's brain was in good agreement with that observed in the adult, the basal ganglia and substantia nigra being the most intensely labelled areas. The development of these receptors throughout the human brain was mainly postnatal: low densities of [125I]GTI binding sites were observed at the fetal/neonatal stage in most regions analyzed, in contrast with the high levels of labelling found in infant and children's brains. Indeed, in a number of regions, including the globus pallidus, substantia nigra and visual cortex, a peak of overexpression of 5‐HT1D receptors was observed in the first decade of life. Such overexpression could support a regulatory role for 5‐HT1D receptors in advanced periods of the CNS developmental process. Our results also indicate that the administration of drugs acting on 5‐HT1D receptors during the early postnatal period of life could result in modifications of their properties, as these receptors are already functional in this period. |
| doi_str_mv | 10.1111/j.1460-9568.1996.tb01166.x |
| format | Article |
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The anatomical distribution of 5‐HT1D receptors in neonatal, infant and children's brain was in good agreement with that observed in the adult, the basal ganglia and substantia nigra being the most intensely labelled areas. The development of these receptors throughout the human brain was mainly postnatal: low densities of [125I]GTI binding sites were observed at the fetal/neonatal stage in most regions analyzed, in contrast with the high levels of labelling found in infant and children's brains. Indeed, in a number of regions, including the globus pallidus, substantia nigra and visual cortex, a peak of overexpression of 5‐HT1D receptors was observed in the first decade of life. Such overexpression could support a regulatory role for 5‐HT1D receptors in advanced periods of the CNS developmental process. Our results also indicate that the administration of drugs acting on 5‐HT1D receptors during the early postnatal period of life could result in modifications of their properties, as these receptors are already functional in this period.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/j.1460-9568.1996.tb01166.x</identifier><identifier>PMID: 8713449</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>[125I]GTI binding sites ; Adult ; Aging - metabolism ; Autoradiography - methods ; Basal Ganglia - metabolism ; Brain - growth & development ; Brain - metabolism ; central nervous system ; Child, Preschool ; Dipeptides - metabolism ; Female ; fetal ; Fetus ; Gene Expression Regulation, Developmental ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Iodine Radioisotopes ; Male ; neonatal ; Organ Specificity ; quantitative receptor autoradiography ; Receptor, Serotonin, 5-HT1D ; Receptors, Serotonin - analysis ; Receptors, Serotonin - biosynthesis ; Receptors, Serotonin - metabolism ; Serotonin - analogs & derivatives ; Serotonin - metabolism ; Substantia Nigra - metabolism</subject><ispartof>The European journal of neuroscience, 1996-01, Vol.8 (1), p.53-60</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1460-9568.1996.tb01166.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1460-9568.1996.tb01166.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8713449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>del Olmo, Elena</creatorcontrib><creatorcontrib>del Arco, Carmen</creatorcontrib><creatorcontrib>Díaz, Alvaro</creatorcontrib><creatorcontrib>Pascual, Julio</creatorcontrib><creatorcontrib>Mengod, Guadalupe</creatorcontrib><creatorcontrib>Palacios, José M.</creatorcontrib><creatorcontrib>Pazos, Angel</creatorcontrib><title>Ontogenetic Development of 5-HT1D Receptors in Human Brain: An Autoradiographic Study</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>The pattern of pre‐ and postnatal appearance of 5‐HT1D receptors throughout the different areas of the human brain was studied by quantitative in vitro autoradiography, using [125I]GTI (serotonin O‐carboxymethyl‐glycyl‐[125I]tyrosinamide) as a ligand. The anatomical distribution of 5‐HT1D receptors in neonatal, infant and children's brain was in good agreement with that observed in the adult, the basal ganglia and substantia nigra being the most intensely labelled areas. The development of these receptors throughout the human brain was mainly postnatal: low densities of [125I]GTI binding sites were observed at the fetal/neonatal stage in most regions analyzed, in contrast with the high levels of labelling found in infant and children's brains. Indeed, in a number of regions, including the globus pallidus, substantia nigra and visual cortex, a peak of overexpression of 5‐HT1D receptors was observed in the first decade of life. Such overexpression could support a regulatory role for 5‐HT1D receptors in advanced periods of the CNS developmental process. Our results also indicate that the administration of drugs acting on 5‐HT1D receptors during the early postnatal period of life could result in modifications of their properties, as these receptors are already functional in this period.</description><subject>[125I]GTI binding sites</subject><subject>Adult</subject><subject>Aging - metabolism</subject><subject>Autoradiography - methods</subject><subject>Basal Ganglia - metabolism</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>central nervous system</subject><subject>Child, Preschool</subject><subject>Dipeptides - metabolism</subject><subject>Female</subject><subject>fetal</subject><subject>Fetus</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Iodine Radioisotopes</subject><subject>Male</subject><subject>neonatal</subject><subject>Organ Specificity</subject><subject>quantitative receptor autoradiography</subject><subject>Receptor, Serotonin, 5-HT1D</subject><subject>Receptors, Serotonin - analysis</subject><subject>Receptors, Serotonin - biosynthesis</subject><subject>Receptors, Serotonin - metabolism</subject><subject>Serotonin - analogs & derivatives</subject><subject>Serotonin - metabolism</subject><subject>Substantia Nigra - metabolism</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PGzEQhi1ERQPlJ1SyeuC2i7_W9lbiEJJAqBBINGl7s7y7s6nDfrEfkPx7HCXKXObwzDuaeRD6QUlIfV2vQyokCeJI6pDGsQz7hFAqZbg5QaMjOkUjEkc80FT--4rOu25NCNFSRGfoTCvKhYhHaPlc9fUKKuhdiqfwDkXdlFD1uM5xFMwXdIpfIIWmr9sOuwrPh9JW-La1rvqJxxUeD57YzNWr1jb__Y7f_ZBtv6EvuS06uDz0C7S8my0m8-Dx-f5hMn4MHIs1D5imGWOJYNz6I0WaSUlBJcpGHIgArizxzyRpnsf-YJ0rEdMUEk4ITZRkKb9AV_u9TVu_DdD1pnRdCkVhK6iHzijNpGRC-sHvh8EhKSEzTetK227NwYPnN3v-4QrYHjElZifcrM3OqtlZNTvh5iDcbMzs11PEfT7Y513Xw-aYt-2rkYqryPx9ujd3i0jPyQszf_gn0NeCPA</recordid><startdate>199601</startdate><enddate>199601</enddate><creator>del Olmo, Elena</creator><creator>del Arco, Carmen</creator><creator>Díaz, Alvaro</creator><creator>Pascual, Julio</creator><creator>Mengod, Guadalupe</creator><creator>Palacios, José M.</creator><creator>Pazos, Angel</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199601</creationdate><title>Ontogenetic Development of 5-HT1D Receptors in Human Brain: An Autoradiographic Study</title><author>del Olmo, Elena ; del Arco, Carmen ; Díaz, Alvaro ; Pascual, Julio ; Mengod, Guadalupe ; Palacios, José M. ; Pazos, Angel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2983-281d22b423a8164cd661e7b7a53e04e37a0460bcff98718f7491ceb3001b762c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>[125I]GTI binding sites</topic><topic>Adult</topic><topic>Aging - metabolism</topic><topic>Autoradiography - methods</topic><topic>Basal Ganglia - metabolism</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>central nervous system</topic><topic>Child, Preschool</topic><topic>Dipeptides - metabolism</topic><topic>Female</topic><topic>fetal</topic><topic>Fetus</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Iodine Radioisotopes</topic><topic>Male</topic><topic>neonatal</topic><topic>Organ Specificity</topic><topic>quantitative receptor autoradiography</topic><topic>Receptor, Serotonin, 5-HT1D</topic><topic>Receptors, Serotonin - analysis</topic><topic>Receptors, Serotonin - biosynthesis</topic><topic>Receptors, Serotonin - metabolism</topic><topic>Serotonin - analogs & derivatives</topic><topic>Serotonin - metabolism</topic><topic>Substantia Nigra - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>del Olmo, Elena</creatorcontrib><creatorcontrib>del Arco, Carmen</creatorcontrib><creatorcontrib>Díaz, Alvaro</creatorcontrib><creatorcontrib>Pascual, Julio</creatorcontrib><creatorcontrib>Mengod, Guadalupe</creatorcontrib><creatorcontrib>Palacios, José M.</creatorcontrib><creatorcontrib>Pazos, Angel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>del Olmo, Elena</au><au>del Arco, Carmen</au><au>Díaz, Alvaro</au><au>Pascual, Julio</au><au>Mengod, Guadalupe</au><au>Palacios, José M.</au><au>Pazos, Angel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ontogenetic Development of 5-HT1D Receptors in Human Brain: An Autoradiographic Study</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>1996-01</date><risdate>1996</risdate><volume>8</volume><issue>1</issue><spage>53</spage><epage>60</epage><pages>53-60</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>The pattern of pre‐ and postnatal appearance of 5‐HT1D receptors throughout the different areas of the human brain was studied by quantitative in vitro autoradiography, using [125I]GTI (serotonin O‐carboxymethyl‐glycyl‐[125I]tyrosinamide) as a ligand. The anatomical distribution of 5‐HT1D receptors in neonatal, infant and children's brain was in good agreement with that observed in the adult, the basal ganglia and substantia nigra being the most intensely labelled areas. The development of these receptors throughout the human brain was mainly postnatal: low densities of [125I]GTI binding sites were observed at the fetal/neonatal stage in most regions analyzed, in contrast with the high levels of labelling found in infant and children's brains. Indeed, in a number of regions, including the globus pallidus, substantia nigra and visual cortex, a peak of overexpression of 5‐HT1D receptors was observed in the first decade of life. Such overexpression could support a regulatory role for 5‐HT1D receptors in advanced periods of the CNS developmental process. 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| subjects | [125I]GTI binding sites Adult Aging - metabolism Autoradiography - methods Basal Ganglia - metabolism Brain - growth & development Brain - metabolism central nervous system Child, Preschool Dipeptides - metabolism Female fetal Fetus Gene Expression Regulation, Developmental Gestational Age Humans Infant Infant, Newborn Iodine Radioisotopes Male neonatal Organ Specificity quantitative receptor autoradiography Receptor, Serotonin, 5-HT1D Receptors, Serotonin - analysis Receptors, Serotonin - biosynthesis Receptors, Serotonin - metabolism Serotonin - analogs & derivatives Serotonin - metabolism Substantia Nigra - metabolism |
| title | Ontogenetic Development of 5-HT1D Receptors in Human Brain: An Autoradiographic Study |
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