Synthesis and in Vitro and in Vivo Characteristics of an Iodinated Analogue of the β-Adrenoceptor Antagonist Carazolol

A new (radio)iodinated, β-adrenoceptor ligand, (S)-(−)-4-[3-[(1,1-dimethyl-3-iodo-(2E)-propenyl)amino]-2-hydroxypropoxy]carbazole (CYBL8E, 1), was prepared. 1 is an iodinated analogue of the high-affinity β-adrenoceptor antagonist carazolol (2). The asymmetric synthesis was achieved in four steps st...

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