EFFECT OF EXTERNAL SODIUM SUBSTITUTION ON POTASSIUM CONTRACTURES OF MAMMALIAN MUSCLES: POSSIBLE INVOLVEMENT OF SARCOLEMMA-BOUND CALCIUM AND Na+-Ca2+ EXCHANGE
Isometric tension of K + contractures, membrane potential, internal Na + activity ( a i N a ) and intracellular pH (pH i ) have been measured in vitro under conditions which modify sarcolemma-bound calcium and the activity of the Na + -Ca 2+ exchange of normal mammalian soleus muscle. In the absence...
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| Veröffentlicht in: | Experimental physiology 1988-03, Vol.73 (2), p.233-236 |
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| creator | Noireaud, J. Leoty, C. |
| description | Isometric tension of K + contractures, membrane potential, internal Na + activity ( a i N a ) and intracellular pH (pH i ) have been measured in vitro under conditions which modify sarcolemma-bound calcium and the activity of the Na + -Ca 2+ exchange of normal mammalian soleus muscle. In the absence of external Na + and for a given high external K + , the maximum amplitude of the contracture was increased (Na + replaced by TEA + ) or decreased (Na+ replaced by Li + or Cs + ) compared with that obtained in the presence of Na + . Replacement of external Na+ by another monovalent cation (TEA + ) did not induce any change of pH i . However the concomitant decrease of a i N a was related to a Na + -Ca 2+ exchange across the sarcolemmal membrane. The data suggest that in soleus muscle, a sarcolemmal calcium pool is involved
during the development of K + contractures. |
| doi_str_mv | 10.1113/expphysiol.1988.sp003136 |
| format | Article |
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during the development of K + contractures.</description><identifier>ISSN: 0958-0670</identifier><identifier>ISSN: 0144-8757</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/expphysiol.1988.sp003136</identifier><identifier>PMID: 3380938</identifier><identifier>CODEN: QJEPD3</identifier><language>eng</language><publisher>Cambridge: The Physiological Society</publisher><subject>Animals ; Biological and medical sciences ; Calcium - metabolism ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Ion Exchange ; Isometric Contraction - drug effects ; Mice ; Mice, Inbred C57BL ; Muscle Contraction - drug effects ; Potassium - pharmacology ; Rats ; Sarcolemma - metabolism ; Sodium - metabolism ; Sodium - pharmacology ; Striated muscle. Tendons ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Experimental physiology, 1988-03, Vol.73 (2), p.233-236</ispartof><rights>1988 The Physiological Society</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2Fexpphysiol.1988.sp003136$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2Fexpphysiol.1988.sp003136$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7793962$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3380938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noireaud, J.</creatorcontrib><creatorcontrib>Leoty, C.</creatorcontrib><title>EFFECT OF EXTERNAL SODIUM SUBSTITUTION ON POTASSIUM CONTRACTURES OF MAMMALIAN MUSCLES: POSSIBLE INVOLVEMENT OF SARCOLEMMA-BOUND CALCIUM AND Na+-Ca2+ EXCHANGE</title><title>Experimental physiology</title><addtitle>Q J Exp Physiol</addtitle><description>Isometric tension of K + contractures, membrane potential, internal Na + activity ( a i N a ) and intracellular pH (pH i ) have been measured in vitro under conditions which modify sarcolemma-bound calcium and the activity of the Na + -Ca 2+ exchange of normal mammalian soleus muscle. In the absence of external Na + and for a given high external K + , the maximum amplitude of the contracture was increased (Na + replaced by TEA + ) or decreased (Na+ replaced by Li + or Cs + ) compared with that obtained in the presence of Na + . Replacement of external Na+ by another monovalent cation (TEA + ) did not induce any change of pH i . However the concomitant decrease of a i N a was related to a Na + -Ca 2+ exchange across the sarcolemmal membrane. The data suggest that in soleus muscle, a sarcolemmal calcium pool is involved
during the development of K + contractures.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Ion Exchange</subject><subject>Isometric Contraction - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Muscle Contraction - drug effects</subject><subject>Potassium - pharmacology</subject><subject>Rats</subject><subject>Sarcolemma - metabolism</subject><subject>Sodium - metabolism</subject><subject>Sodium - pharmacology</subject><subject>Striated muscle. Tendons</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0958-0670</issn><issn>0144-8757</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkV1r2zAUhs3Y6LJuP2Hgi7Gb4kzSsS15d46qNAZ_lNguvROKPxYPp_Gshi4_Zv-1cpO1IJA473POe9BrWTZGc4wx_Gj-DsP2qLt9P8cBY3M9IAQY_HfWDLt-4Liud__emqHAYw7yKfpofdL6N0IYEHMvrAsAhgJgM-ufWC4FL-xsaYv7QqzTMLbz7DoqEzsvF3kRFWURZaltzm1WhHk-KTxLi3XIi3It8qkzCZMkjKMwtZMy57HIfxrYoItY2FF6l8V3IhHpi0kernkWC8M7i6xMr20exnyaGZp3qq4crsiVWYWvwvRGfLY-tKrXzZfzfWmVS1HwlRNnN5HpdLaYAjgVqbAXqKpFgNoWaozpJiCKsrqlLtQVdbFPa7rxXFQTD5giDQVMsI8YIoaES-v7ae4w7v8cGv0od52umr5XD83-oCVlxAfmMwN-PYOHza6p5TB2OzUe5fk_jf7trCtdqb4d1UPV6VeM0gACf_LjJ-yp65vjq4yRnNKVb-nKKV35P10pbldTgQIhAG9bb7tf26dubOSpS--rrnk0biCJnMBnBxKd5Q</recordid><startdate>198803</startdate><enddate>198803</enddate><creator>Noireaud, J.</creator><creator>Leoty, C.</creator><general>The Physiological Society</general><general>Cambridge University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198803</creationdate><title>EFFECT OF EXTERNAL SODIUM SUBSTITUTION ON POTASSIUM CONTRACTURES OF MAMMALIAN MUSCLES: POSSIBLE INVOLVEMENT OF SARCOLEMMA-BOUND CALCIUM AND Na+-Ca2+ EXCHANGE</title><author>Noireaud, J. ; Leoty, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h1733-c2c159acf030ff3d117b92a78df743dc74167d7b540d2538a2e7312160802b923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Ion Exchange</topic><topic>Isometric Contraction - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Muscle Contraction - drug effects</topic><topic>Potassium - pharmacology</topic><topic>Rats</topic><topic>Sarcolemma - metabolism</topic><topic>Sodium - metabolism</topic><topic>Sodium - pharmacology</topic><topic>Striated muscle. Tendons</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noireaud, J.</creatorcontrib><creatorcontrib>Leoty, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noireaud, J.</au><au>Leoty, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF EXTERNAL SODIUM SUBSTITUTION ON POTASSIUM CONTRACTURES OF MAMMALIAN MUSCLES: POSSIBLE INVOLVEMENT OF SARCOLEMMA-BOUND CALCIUM AND Na+-Ca2+ EXCHANGE</atitle><jtitle>Experimental physiology</jtitle><addtitle>Q J Exp Physiol</addtitle><date>1988-03</date><risdate>1988</risdate><volume>73</volume><issue>2</issue><spage>233</spage><epage>236</epage><pages>233-236</pages><issn>0958-0670</issn><issn>0144-8757</issn><eissn>1469-445X</eissn><coden>QJEPD3</coden><abstract>Isometric tension of K + contractures, membrane potential, internal Na + activity ( a i N a ) and intracellular pH (pH i ) have been measured in vitro under conditions which modify sarcolemma-bound calcium and the activity of the Na + -Ca 2+ exchange of normal mammalian soleus muscle. In the absence of external Na + and for a given high external K + , the maximum amplitude of the contracture was increased (Na + replaced by TEA + ) or decreased (Na+ replaced by Li + or Cs + ) compared with that obtained in the presence of Na + . Replacement of external Na+ by another monovalent cation (TEA + ) did not induce any change of pH i . However the concomitant decrease of a i N a was related to a Na + -Ca 2+ exchange across the sarcolemmal membrane. The data suggest that in soleus muscle, a sarcolemmal calcium pool is involved
during the development of K + contractures.</abstract><cop>Cambridge</cop><pub>The Physiological Society</pub><pmid>3380938</pmid><doi>10.1113/expphysiol.1988.sp003136</doi><tpages>4</tpages></addata></record> |
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| ispartof | Experimental physiology, 1988-03, Vol.73 (2), p.233-236 |
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| source | MEDLINE; Wiley Journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Calcium - metabolism Fundamental and applied biological sciences. Psychology In Vitro Techniques Ion Exchange Isometric Contraction - drug effects Mice Mice, Inbred C57BL Muscle Contraction - drug effects Potassium - pharmacology Rats Sarcolemma - metabolism Sodium - metabolism Sodium - pharmacology Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system |
| title | EFFECT OF EXTERNAL SODIUM SUBSTITUTION ON POTASSIUM CONTRACTURES OF MAMMALIAN MUSCLES: POSSIBLE INVOLVEMENT OF SARCOLEMMA-BOUND CALCIUM AND Na+-Ca2+ EXCHANGE |
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