Altered brain sodium channel transcript levels in human epilepsy

Normal, and perhaps pathological, characteristics of neuronal excitability are related to the distribution and density of voltage-gated ion channels such as the sodium channel. We studied normal and epileptic human brain using the ligase detection reaction to measure the relative quantities of mRNAs...

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Veröffentlicht in:	Brain research. Molecular brain research. 1996, Vol.35 (1), p.84-90
Hauptverfasser:	Lombardo, Anthony J., Kuzniecky, Ruben, Powers, Richard E., Brown, George B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Base Sequence Biological and medical sciences Brain - metabolism DNA Primers Epilepsy Epilepsy - metabolism Epilepsy - physiopathology Epilepsy - surgery Female Frontal Lobe - metabolism Frontal Lobe - pathology Frontal Lobe - surgery Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Ion channel Ligase detection reaction Male Medical sciences Molecular Sequence Data mRNA quantitation Nervous system (semeiology, syndromes) Neurology Oligonucleotide Probes Organ Specificity Polymerase Chain Reaction Pyramidal Cells - metabolism Reference Values RNA, Messenger - analysis RNA, Messenger - biosynthesis Sodium channel Sodium Channels - biosynthesis Sodium Channels - classification Temporal Lobe - metabolism Temporal Lobe - pathology Temporal Lobe - surgery Transcription, Genetic
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