Interleukin-2-dependent T lymphocytes for the diagnosis and investigation of inherited metabolic disorders
Interleukin-2-dependent T cell lines can be started from as little as 1 ml of peripheral blood and expanded to 50 × 10 6 cells within 12 days. These cells represent an easily obtainable source of nucleated tissue with certain advantages over skin fibroblasts or transformed B lymphoblastoid cells for...
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| Veröffentlicht in: | Clinica chimica acta 1988-04, Vol.173 (2), p.147-156 |
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| container_end_page | 156 |
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| container_issue | 2 |
| container_start_page | 147 |
| container_title | Clinica chimica acta |
| container_volume | 173 |
| creator | Adolph, Kelvin Kucey, Mark T. Hodges, Stephen D. Carter, Robert J. Snyder, Floyd F. |
| description | Interleukin-2-dependent T cell lines can be started from as little as 1 ml of peripheral blood and expanded to 50 × 10
6 cells within 12 days. These cells represent an easily obtainable source of nucleated tissue with certain advantages over skin fibroblasts or transformed B lymphoblastoid cells for the rapid diagnosis and study of inherited metabolic disorders. A panel of 19 enzymes were assayed in IL-2-dependent T lymphocytes and the diagnosis of four enzyme deficiencies is demonstrated using T lymphocytes. |
| doi_str_mv | 10.1016/0009-8981(88)90252-5 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0009-8981 |
| ispartof | Clinica chimica acta, 1988-04, Vol.173 (2), p.147-156 |
| issn | 0009-8981 1873-3492 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78261236 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Cells, Cultured Errors of metabolism Humans Inherited metabolic disease Interleukin-2 Interleukin-2 - physiology Medical sciences Metabolic diseases Metabolism, Inborn Errors - diagnosis Metabolism, Inborn Errors - enzymology T lymphocytes T-Lymphocytes - enzymology T-Lymphocytes - physiology |
| title | Interleukin-2-dependent T lymphocytes for the diagnosis and investigation of inherited metabolic disorders |
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