Slow Penetration of Thyrotropin‐Releasing Hormone Across the Blood‐Brain Barrier of an In Situ Perfused Guinea Pig Brain

Transport of 3H‐labelled thyrotropin‐releasing hormone (TRH) across the blood‐brain barrier was studied in the ipsilateral perfused in situ guinea pig forebrain. The unidirectional transfer constant (Kin) calculated from the multiple time brain uptake analysis ranged from 1.14 × 10‐−3 to 1.22 × 10‐−...

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Veröffentlicht in:	Journal of neurochemistry 1988-07, Vol.51 (1), p.252-257
Hauptverfasser:	Zloković, Berislav V., Lipovac, Milo N., Begley, David J., Davson, Hugh, Rakić, Ljubiša
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacitracin - pharmacology Biological and medical sciences Blood-Brain Barrier Brain - blood supply Brain - drug effects Brain - metabolism Capillary Permeability Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Female Fundamental and applied biological sciences. Psychology Guinea pig Guinea Pigs Hippocampus - drug effects Hippocampus - metabolism Male Mannitol - metabolism Parietal Lobe - drug effects Parietal Lobe - metabolism Perfused brain Perfusion Proline - analogs & derivatives Proline - pharmacology thyroid-stimulating hormone-releasing hormone Thyrotropin-Releasing Hormone - metabolism Thyrotropin‐releasing hormone Unidirectional transfer constant Vertebrates: nervous system and sense organs
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