Extended Length Heterobifunctional Coupling Agents for Protein Conjugations

A series of extended length heterobifunctional coupling agents is described. The successive aminocaproic acid homologation of succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate, a known 9-atom long maleimide active ester linker, yielded 16-, 23-, and 30-atom long maleimide active ester homo...

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Veröffentlicht in:	Bioconjugate chemistry 1996-01, Vol.7 (1), p.88-95
Hauptverfasser:	Bieniarz, Christopher, Husain, Mazhar, Barnes, Grady, King, Carol A, Welch, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase alpha-Fetoproteins - immunology Animals Antibodies Antibodies, Monoclonal CA-125 Antigen - immunology Cattle Cross-Linking Reagents - chemical synthesis Cross-Linking Reagents - chemistry Immunoassay Immunoglobulin G Maleimides - chemical synthesis Proteins Spectrometry, Mass, Fast Atom Bombardment Structure-Activity Relationship
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