A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain (or dysesthesia) were produced. Hyperalgesic responses to...
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| Veröffentlicht in: | Pain (Amsterdam) 1988-04, Vol.33 (1), p.87-107 |
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| creator | Bennett, Gary J. Xie, Y.-K. |
| description | A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain (or dysesthesia) were produced. Hyperalgesic responses to noxious radiant heat were evident on the second postoperative day and lasted for over 2 months. Hyperalgesic responses to chemogenic pain were also present. The presence of allodynia was inferred from the nocifensive responses evoked by standing on an innocuous, chilled metal floor or by innocuous mechanical stimulation, and by the rats' persistence in holding the hind paw in a guarded position. The presence of spontaneous pain was suggested by a suppression of appetite and by the frequent occurrence of apparently spontaneous nocifensive responses. The affected hind paw was abnormally warm or cool in about one-third of the rats. About one-half of the rats developed grossly overgrown claws on the affected side. Experiments with this animal model may advance our understanding of the neural mechanisms of neuropathic pain disorders in humans. |
| doi_str_mv | 10.1016/0304-3959(88)90209-6 |
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The postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain (or dysesthesia) were produced. Hyperalgesic responses to noxious radiant heat were evident on the second postoperative day and lasted for over 2 months. Hyperalgesic responses to chemogenic pain were also present. The presence of allodynia was inferred from the nocifensive responses evoked by standing on an innocuous, chilled metal floor or by innocuous mechanical stimulation, and by the rats' persistence in holding the hind paw in a guarded position. The presence of spontaneous pain was suggested by a suppression of appetite and by the frequent occurrence of apparently spontaneous nocifensive responses. The affected hind paw was abnormally warm or cool in about one-third of the rats. About one-half of the rats developed grossly overgrown claws on the affected side. Experiments with this animal model may advance our understanding of the neural mechanisms of neuropathic pain disorders in humans.</description><identifier>ISSN: 0304-3959</identifier><identifier>EISSN: 1872-6623</identifier><identifier>DOI: 10.1016/0304-3959(88)90209-6</identifier><identifier>PMID: 2837713</identifier><identifier>CODEN: PAINDB</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Allodynia ; Animals ; Behavior, Animal ; Biological and medical sciences ; Causalgia ; Cold Temperature ; Hot Temperature ; Hyperalgesia ; Hyperalgesia - etiology ; Hyperalgesia - physiopathology ; Hyperesthesia - etiology ; Ligation ; Male ; Medical sciences ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Neurons, Afferent - physiology ; Pain - etiology ; Pain - physiopathology ; Painful neuropathy ; Peripheral Nervous System Diseases - complications ; Peripheral Nervous System Diseases - physiopathology ; Rats ; Rats, Inbred Strains ; Reaction Time - physiology ; Sciatic Nerve - physiopathology ; Skin - innervation ; Skin - physiopathology ; Time Factors</subject><ispartof>Pain (Amsterdam), 1988-04, Vol.33 (1), p.87-107</ispartof><rights>1988</rights><rights>Lippincott-Raven Publishers.Copyright © Lippincott-Raven Publishers.</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4874-389c9549bf60f4a98752e09effa1edffb3a2a1d4eb69bed2b91d64714e21670b3</citedby><cites>FETCH-LOGICAL-c4874-389c9549bf60f4a98752e09effa1edffb3a2a1d4eb69bed2b91d64714e21670b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3959(88)90209-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7005715$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2837713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bennett, Gary J.</creatorcontrib><creatorcontrib>Xie, Y.-K.</creatorcontrib><title>A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man</title><title>Pain (Amsterdam)</title><addtitle>Pain</addtitle><description>A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain (or dysesthesia) were produced. Hyperalgesic responses to noxious radiant heat were evident on the second postoperative day and lasted for over 2 months. Hyperalgesic responses to chemogenic pain were also present. The presence of allodynia was inferred from the nocifensive responses evoked by standing on an innocuous, chilled metal floor or by innocuous mechanical stimulation, and by the rats' persistence in holding the hind paw in a guarded position. The presence of spontaneous pain was suggested by a suppression of appetite and by the frequent occurrence of apparently spontaneous nocifensive responses. The affected hind paw was abnormally warm or cool in about one-third of the rats. About one-half of the rats developed grossly overgrown claws on the affected side. Experiments with this animal model may advance our understanding of the neural mechanisms of neuropathic pain disorders in humans.</description><subject>Allodynia</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>Causalgia</subject><subject>Cold Temperature</subject><subject>Hot Temperature</subject><subject>Hyperalgesia</subject><subject>Hyperalgesia - etiology</subject><subject>Hyperalgesia - physiopathology</subject><subject>Hyperesthesia - etiology</subject><subject>Ligation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Neurons, Afferent - physiology</subject><subject>Pain - etiology</subject><subject>Pain - physiopathology</subject><subject>Painful neuropathy</subject><subject>Peripheral Nervous System Diseases - complications</subject><subject>Peripheral Nervous System Diseases - physiopathology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reaction Time - physiology</subject><subject>Sciatic Nerve - physiopathology</subject><subject>Skin - innervation</subject><subject>Skin - physiopathology</subject><subject>Time Factors</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoYzv6DxRqIaKL0rwqj40wDL5gwI2uQyq5oeJUJ2VS5TD_3rTdtDtdJCG53zm5nIvQc4LfEkzEO8ww75ke9Gul3mhMse7FA7QjStJeCMoeot0ZeYye1PoDY0wp1RfogiomJWE75K66BUpcJih27vY55QRbyYtdp_supq7YtVunti0l-81B7XysuXgotcuhW2xjKqRq15hTN8dbaHiu0B4hHQz2Nj1Fj4KdKzw7nZfo-8cP364_9zdfP325vrrpHVey9am00wPXYxA4cKuVHChgDSFYAj6EkVlqiecwCj2Cp6MmXnBJOFAiJB7ZJXp19G29_tygrmYfq4N5tgnyVo1UdGCCs_-CZMADwVI1kB9BV3KtBYJZStzbcm8INochmEPC5pCwUcr8GYIRTfbi5L-Ne_Bn0Sn1Vn95qtvq7ByKTS7WMyYxHiQZ_v5-l-e1BX47b3dQzAR2XifThokF06InWinM261vi_Ame3-UQcv6V2yK6iIkBz4WcKvxOf67_d9h6LNF</recordid><startdate>19880401</startdate><enddate>19880401</enddate><creator>Bennett, Gary J.</creator><creator>Xie, Y.-K.</creator><general>Elsevier B.V</general><general>Lippincott-Raven Publishers.Copyright Lippincott-Raven Publishers</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19880401</creationdate><title>A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man</title><author>Bennett, Gary J. ; Xie, Y.-K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4874-389c9549bf60f4a98752e09effa1edffb3a2a1d4eb69bed2b91d64714e21670b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Allodynia</topic><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Biological and medical sciences</topic><topic>Causalgia</topic><topic>Cold Temperature</topic><topic>Hot Temperature</topic><topic>Hyperalgesia</topic><topic>Hyperalgesia - etiology</topic><topic>Hyperalgesia - physiopathology</topic><topic>Hyperesthesia - etiology</topic><topic>Ligation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Neurons, Afferent - physiology</topic><topic>Pain - etiology</topic><topic>Pain - physiopathology</topic><topic>Painful neuropathy</topic><topic>Peripheral Nervous System Diseases - complications</topic><topic>Peripheral Nervous System Diseases - physiopathology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reaction Time - physiology</topic><topic>Sciatic Nerve - physiopathology</topic><topic>Skin - innervation</topic><topic>Skin - physiopathology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bennett, Gary J.</creatorcontrib><creatorcontrib>Xie, Y.-K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bennett, Gary J.</au><au>Xie, Y.-K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>1988-04-01</date><risdate>1988</risdate><volume>33</volume><issue>1</issue><spage>87</spage><epage>107</epage><pages>87-107</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><coden>PAINDB</coden><abstract>A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain (or dysesthesia) were produced. Hyperalgesic responses to noxious radiant heat were evident on the second postoperative day and lasted for over 2 months. Hyperalgesic responses to chemogenic pain were also present. The presence of allodynia was inferred from the nocifensive responses evoked by standing on an innocuous, chilled metal floor or by innocuous mechanical stimulation, and by the rats' persistence in holding the hind paw in a guarded position. The presence of spontaneous pain was suggested by a suppression of appetite and by the frequent occurrence of apparently spontaneous nocifensive responses. The affected hind paw was abnormally warm or cool in about one-third of the rats. About one-half of the rats developed grossly overgrown claws on the affected side. Experiments with this animal model may advance our understanding of the neural mechanisms of neuropathic pain disorders in humans.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2837713</pmid><doi>10.1016/0304-3959(88)90209-6</doi><tpages>21</tpages></addata></record> |
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| ispartof | Pain (Amsterdam), 1988-04, Vol.33 (1), p.87-107 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Allodynia Animals Behavior, Animal Biological and medical sciences Causalgia Cold Temperature Hot Temperature Hyperalgesia Hyperalgesia - etiology Hyperalgesia - physiopathology Hyperesthesia - etiology Ligation Male Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Neurons, Afferent - physiology Pain - etiology Pain - physiopathology Painful neuropathy Peripheral Nervous System Diseases - complications Peripheral Nervous System Diseases - physiopathology Rats Rats, Inbred Strains Reaction Time - physiology Sciatic Nerve - physiopathology Skin - innervation Skin - physiopathology Time Factors |
| title | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man |
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