Collagen-type synthesis in human-hair papilla cells in culture

Hair-papilla derived cells were grown in monolayer culture and revealed the typical morphology and growth pattern which was similar but not identical to control fibroblasts. Hair-papilla cells were found to produce considerable amounts of collagen type I and type III and fibronectin. Type IV collage...

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Veröffentlicht in:Archives of Dermatological Research 1988-01, Vol.280 (3), p.140-144
Hauptverfasser: KATSUOKA, K, MAUCH, C, SCHELL, H, HORNSTEIN, O. P, KRIEG, T
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Sprache:eng
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Zusammenfassung:Hair-papilla derived cells were grown in monolayer culture and revealed the typical morphology and growth pattern which was similar but not identical to control fibroblasts. Hair-papilla cells were found to produce considerable amounts of collagen type I and type III and fibronectin. Type IV collagen production could not be detected. The ratio of collagen type III and type I clearly differed from the pattern observed in normal fibroblasts, being much higher in hair-papilla cells, where type III accounted for more than 20% of total collagen synthesis. These data show that hair-papilla derived cells have biosynthetic capacities similar to those of human skin fibroblasts as well as characteristic differences, indicating that they represent a specialized fibroblast subpopulation.
ISSN:0340-3696
1432-069X
DOI:10.1007/BF00456843