Role of bacterial vaginosis–associated microorganisms in endometritis
OBJECTIVE: Our goal was to define the role of bacterial vaginosis and bacterial vaginosis–associated microorganisms in endometritis. STUDY DESIGN: Endometrial biopsies were obtained for histologic and microbiologic study from 178 consecutive women with suspected pelvic inflammatory disease, and 85 o...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1996-08, Vol.175 (2), p.435-441 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Hillier, Sharon L. Kiviat, Nancy B. Hawes, Stephen E. Hasselquist, Mary Beth Hanssen, Pål Wølner Eschenbach, David A. Holmes, King K. |
| description | OBJECTIVE: Our goal was to define the role of bacterial vaginosis and bacterial vaginosis–associated microorganisms in endometritis.
STUDY DESIGN: Endometrial biopsies were obtained for histologic and microbiologic study from 178 consecutive women with suspected pelvic inflammatory disease, and 85 of them underwent laparoscopy to diagnose salpingitis.
RESULTS: Histologic endometritis was confirmed in 117 (65%) of the women. Among women who underwent laparoscopy, salpingitis was present in 68% of those with and 23% of those without endometritis. Some but not all bacterial vaginosis–associated microorganisms were linked with endometritis. By logistic regression analysis, after adjustment for bacterial vaginosis and isolation of
Neisseria gonorrhoeae and
Chlamydia trachomatis, endometritis was associated with endometrial
N. gonorrhoeae (odds ratio 5.7, 95% confidence interval 1.8 to 17.5),
C. trachomatis (odds ratio 4.8, 95% confidence interval 1.3 to 18.2), anaerobic gram-negative rods (odds ratio 2.6, 95% confidence interval 1.1 to 5.7), and nonwhite race (odds ratio 2.3, 95% confidence interval 1.1 to 4.8).
CONCLUSIONS: The association of anaerobic gram-negative rods with endometritis, after adjustment for bacterial vaginosis,
N. gonorrhoeae, and
C. trachomatis, supports the role of these microorganisms in the etiology of histologic endometritis among women with clinically suspected pelvic inflammatory disease. (Am J Obstet Gynecol 1996;175:435-41.) |
| doi_str_mv | 10.1016/S0002-9378(96)70158-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78249518</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002937896701588</els_id><sourcerecordid>78249518</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-15e240eec6312e56bfce2fb17ae59164547553481bf0c5d4ace418aca965a0d93</originalsourceid><addsrcrecordid>eNqFkEtOwzAQhr0AlVI4QqWsECwCtmM79gqhCgpSJSQea8txJpVREhc7rcSOO3BDTkLSVt2yGs3jn3_mQ2hK8DXBRNy8YoxpqrJcXipxlWPCZSqP0PhQPkGnMX4MKVV0hEYyF5wKPkbzF19D4qukMLaD4EydbMzStT66-Pv9Y2L01pkOyqRxNngflqZ1sYmJaxNoS99AF1zn4hk6rkwd4XwfJ-j94f5t9pgunudPs7tFalkuu5RwoAwDWJERClwUlQVaFSQ3wBURjLOc84xJUlTY8pIZC4xIY40S3OBSZRN0sdu7Cv5zDbHTjYsW6tq04NdR55IyxYnsB_lusL86xgCVXgXXmPClCdYDNL2Fpgc6Wgm9haYH3XRvsC4aKA-qPbG-f7vrQ__lxkHQ0TpoLZQugO106d0_Dn_PNYAb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78249518</pqid></control><display><type>article</type><title>Role of bacterial vaginosis–associated microorganisms in endometritis</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Hillier, Sharon L. ; Kiviat, Nancy B. ; Hawes, Stephen E. ; Hasselquist, Mary Beth ; Hanssen, Pål Wølner ; Eschenbach, David A. ; Holmes, King K.</creator><creatorcontrib>Hillier, Sharon L. ; Kiviat, Nancy B. ; Hawes, Stephen E. ; Hasselquist, Mary Beth ; Hanssen, Pål Wølner ; Eschenbach, David A. ; Holmes, King K.</creatorcontrib><description>OBJECTIVE: Our goal was to define the role of bacterial vaginosis and bacterial vaginosis–associated microorganisms in endometritis.
STUDY DESIGN: Endometrial biopsies were obtained for histologic and microbiologic study from 178 consecutive women with suspected pelvic inflammatory disease, and 85 of them underwent laparoscopy to diagnose salpingitis.
RESULTS: Histologic endometritis was confirmed in 117 (65%) of the women. Among women who underwent laparoscopy, salpingitis was present in 68% of those with and 23% of those without endometritis. Some but not all bacterial vaginosis–associated microorganisms were linked with endometritis. By logistic regression analysis, after adjustment for bacterial vaginosis and isolation of
Neisseria gonorrhoeae and
Chlamydia trachomatis, endometritis was associated with endometrial
N. gonorrhoeae (odds ratio 5.7, 95% confidence interval 1.8 to 17.5),
C. trachomatis (odds ratio 4.8, 95% confidence interval 1.3 to 18.2), anaerobic gram-negative rods (odds ratio 2.6, 95% confidence interval 1.1 to 5.7), and nonwhite race (odds ratio 2.3, 95% confidence interval 1.1 to 4.8).
CONCLUSIONS: The association of anaerobic gram-negative rods with endometritis, after adjustment for bacterial vaginosis,
N. gonorrhoeae, and
C. trachomatis, supports the role of these microorganisms in the etiology of histologic endometritis among women with clinically suspected pelvic inflammatory disease. (Am J Obstet Gynecol 1996;175:435-41.)</description><identifier>ISSN: 0002-9378</identifier><identifier>DOI: 10.1016/S0002-9378(96)70158-8</identifier><identifier>PMID: 8765265</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adult ; anaerobic gram negative rods ; bacterial vaginosis ; Chlamydia trachomatis - isolation & purification ; Endometritis ; Endometritis - microbiology ; Female ; Gram-Negative Bacteria - isolation & purification ; Humans ; Middle Aged ; Neisseria gonorrhoeae - isolation & purification ; Odds Ratio ; Regression Analysis ; Vaginosis, Bacterial - microbiology</subject><ispartof>American journal of obstetrics and gynecology, 1996-08, Vol.175 (2), p.435-441</ispartof><rights>1996 Mosby, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-15e240eec6312e56bfce2fb17ae59164547553481bf0c5d4ace418aca965a0d93</citedby><cites>FETCH-LOGICAL-c478t-15e240eec6312e56bfce2fb17ae59164547553481bf0c5d4ace418aca965a0d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9378(96)70158-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8765265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hillier, Sharon L.</creatorcontrib><creatorcontrib>Kiviat, Nancy B.</creatorcontrib><creatorcontrib>Hawes, Stephen E.</creatorcontrib><creatorcontrib>Hasselquist, Mary Beth</creatorcontrib><creatorcontrib>Hanssen, Pål Wølner</creatorcontrib><creatorcontrib>Eschenbach, David A.</creatorcontrib><creatorcontrib>Holmes, King K.</creatorcontrib><title>Role of bacterial vaginosis–associated microorganisms in endometritis</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>OBJECTIVE: Our goal was to define the role of bacterial vaginosis and bacterial vaginosis–associated microorganisms in endometritis.
STUDY DESIGN: Endometrial biopsies were obtained for histologic and microbiologic study from 178 consecutive women with suspected pelvic inflammatory disease, and 85 of them underwent laparoscopy to diagnose salpingitis.
RESULTS: Histologic endometritis was confirmed in 117 (65%) of the women. Among women who underwent laparoscopy, salpingitis was present in 68% of those with and 23% of those without endometritis. Some but not all bacterial vaginosis–associated microorganisms were linked with endometritis. By logistic regression analysis, after adjustment for bacterial vaginosis and isolation of
Neisseria gonorrhoeae and
Chlamydia trachomatis, endometritis was associated with endometrial
N. gonorrhoeae (odds ratio 5.7, 95% confidence interval 1.8 to 17.5),
C. trachomatis (odds ratio 4.8, 95% confidence interval 1.3 to 18.2), anaerobic gram-negative rods (odds ratio 2.6, 95% confidence interval 1.1 to 5.7), and nonwhite race (odds ratio 2.3, 95% confidence interval 1.1 to 4.8).
CONCLUSIONS: The association of anaerobic gram-negative rods with endometritis, after adjustment for bacterial vaginosis,
N. gonorrhoeae, and
C. trachomatis, supports the role of these microorganisms in the etiology of histologic endometritis among women with clinically suspected pelvic inflammatory disease. (Am J Obstet Gynecol 1996;175:435-41.)</description><subject>Adult</subject><subject>anaerobic gram negative rods</subject><subject>bacterial vaginosis</subject><subject>Chlamydia trachomatis - isolation & purification</subject><subject>Endometritis</subject><subject>Endometritis - microbiology</subject><subject>Female</subject><subject>Gram-Negative Bacteria - isolation & purification</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neisseria gonorrhoeae - isolation & purification</subject><subject>Odds Ratio</subject><subject>Regression Analysis</subject><subject>Vaginosis, Bacterial - microbiology</subject><issn>0002-9378</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtOwzAQhr0AlVI4QqWsECwCtmM79gqhCgpSJSQea8txJpVREhc7rcSOO3BDTkLSVt2yGs3jn3_mQ2hK8DXBRNy8YoxpqrJcXipxlWPCZSqP0PhQPkGnMX4MKVV0hEYyF5wKPkbzF19D4qukMLaD4EydbMzStT66-Pv9Y2L01pkOyqRxNngflqZ1sYmJaxNoS99AF1zn4hk6rkwd4XwfJ-j94f5t9pgunudPs7tFalkuu5RwoAwDWJERClwUlQVaFSQ3wBURjLOc84xJUlTY8pIZC4xIY40S3OBSZRN0sdu7Cv5zDbHTjYsW6tq04NdR55IyxYnsB_lusL86xgCVXgXXmPClCdYDNL2Fpgc6Wgm9haYH3XRvsC4aKA-qPbG-f7vrQ__lxkHQ0TpoLZQugO106d0_Dn_PNYAb</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>Hillier, Sharon L.</creator><creator>Kiviat, Nancy B.</creator><creator>Hawes, Stephen E.</creator><creator>Hasselquist, Mary Beth</creator><creator>Hanssen, Pål Wølner</creator><creator>Eschenbach, David A.</creator><creator>Holmes, King K.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960801</creationdate><title>Role of bacterial vaginosis–associated microorganisms in endometritis</title><author>Hillier, Sharon L. ; Kiviat, Nancy B. ; Hawes, Stephen E. ; Hasselquist, Mary Beth ; Hanssen, Pål Wølner ; Eschenbach, David A. ; Holmes, King K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-15e240eec6312e56bfce2fb17ae59164547553481bf0c5d4ace418aca965a0d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>anaerobic gram negative rods</topic><topic>bacterial vaginosis</topic><topic>Chlamydia trachomatis - isolation & purification</topic><topic>Endometritis</topic><topic>Endometritis - microbiology</topic><topic>Female</topic><topic>Gram-Negative Bacteria - isolation & purification</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neisseria gonorrhoeae - isolation & purification</topic><topic>Odds Ratio</topic><topic>Regression Analysis</topic><topic>Vaginosis, Bacterial - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hillier, Sharon L.</creatorcontrib><creatorcontrib>Kiviat, Nancy B.</creatorcontrib><creatorcontrib>Hawes, Stephen E.</creatorcontrib><creatorcontrib>Hasselquist, Mary Beth</creatorcontrib><creatorcontrib>Hanssen, Pål Wølner</creatorcontrib><creatorcontrib>Eschenbach, David A.</creatorcontrib><creatorcontrib>Holmes, King K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hillier, Sharon L.</au><au>Kiviat, Nancy B.</au><au>Hawes, Stephen E.</au><au>Hasselquist, Mary Beth</au><au>Hanssen, Pål Wølner</au><au>Eschenbach, David A.</au><au>Holmes, King K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of bacterial vaginosis–associated microorganisms in endometritis</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>175</volume><issue>2</issue><spage>435</spage><epage>441</epage><pages>435-441</pages><issn>0002-9378</issn><abstract>OBJECTIVE: Our goal was to define the role of bacterial vaginosis and bacterial vaginosis–associated microorganisms in endometritis.
STUDY DESIGN: Endometrial biopsies were obtained for histologic and microbiologic study from 178 consecutive women with suspected pelvic inflammatory disease, and 85 of them underwent laparoscopy to diagnose salpingitis.
RESULTS: Histologic endometritis was confirmed in 117 (65%) of the women. Among women who underwent laparoscopy, salpingitis was present in 68% of those with and 23% of those without endometritis. Some but not all bacterial vaginosis–associated microorganisms were linked with endometritis. By logistic regression analysis, after adjustment for bacterial vaginosis and isolation of
Neisseria gonorrhoeae and
Chlamydia trachomatis, endometritis was associated with endometrial
N. gonorrhoeae (odds ratio 5.7, 95% confidence interval 1.8 to 17.5),
C. trachomatis (odds ratio 4.8, 95% confidence interval 1.3 to 18.2), anaerobic gram-negative rods (odds ratio 2.6, 95% confidence interval 1.1 to 5.7), and nonwhite race (odds ratio 2.3, 95% confidence interval 1.1 to 4.8).
CONCLUSIONS: The association of anaerobic gram-negative rods with endometritis, after adjustment for bacterial vaginosis,
N. gonorrhoeae, and
C. trachomatis, supports the role of these microorganisms in the etiology of histologic endometritis among women with clinically suspected pelvic inflammatory disease. (Am J Obstet Gynecol 1996;175:435-41.)</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>8765265</pmid><doi>10.1016/S0002-9378(96)70158-8</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1996-08, Vol.175 (2), p.435-441 |
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| subjects | Adult anaerobic gram negative rods bacterial vaginosis Chlamydia trachomatis - isolation & purification Endometritis Endometritis - microbiology Female Gram-Negative Bacteria - isolation & purification Humans Middle Aged Neisseria gonorrhoeae - isolation & purification Odds Ratio Regression Analysis Vaginosis, Bacterial - microbiology |
| title | Role of bacterial vaginosis–associated microorganisms in endometritis |
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