Two distinct deficits of visual tracking caused by unilateral lesions of cerebral cortex in humans
We studied horizontal visual tracking in 20 patients with unilateral cerebral lesions and in 10 age‐matched control subjects. Five patients, all with posterior lesions, showed impaired smooth pursuit of predictable targets moving toward the side of the cerebral lesion. Using nonpredictable step‐ramp...
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| Veröffentlicht in: | Annals of neurology 1988-03, Vol.23 (3), p.266-273 |
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| container_title | Annals of neurology |
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| creator | Thurston, Stephen E. Leigh, R. John Crawford, Trevor Thompson, Alan Kennard, Christopher |
| description | We studied horizontal visual tracking in 20 patients with unilateral cerebral lesions and in 10 age‐matched control subjects. Five patients, all with posterior lesions, showed impaired smooth pursuit of predictable targets moving toward the side of the cerebral lesion. Using nonpredictable step‐ramp stimuli, we identified two distinct deficits of visual tracking. The first was a unidirectional deficit of smooth pursuit, for targets moving toward the side of the lesion, in response to stimuli presented into either visual hemifield. The second deficit, identified in a sixth patient who did not show pursuit asymmetry to predictable targets, was a bidirectional inability to estimate the speed of a moving target in the visual hemifield contralateral to the side of the lesion; this caused inaccurate saccades to moving (but not stationary) targets and impaired smooth pursuit initiation. These visual tracking deficits were independent of homonymous hemianopia or hemispatial neglect. These two tracking deficits are similar to those described in rhesus monkeys with lesions of the medial superior temporal and middle temporal visual areas. |
| doi_str_mv | 10.1002/ana.410230309 |
| format | Article |
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John ; Crawford, Trevor ; Thompson, Alan ; Kennard, Christopher</creator><creatorcontrib>Thurston, Stephen E. ; Leigh, R. John ; Crawford, Trevor ; Thompson, Alan ; Kennard, Christopher</creatorcontrib><description>We studied horizontal visual tracking in 20 patients with unilateral cerebral lesions and in 10 age‐matched control subjects. Five patients, all with posterior lesions, showed impaired smooth pursuit of predictable targets moving toward the side of the cerebral lesion. Using nonpredictable step‐ramp stimuli, we identified two distinct deficits of visual tracking. The first was a unidirectional deficit of smooth pursuit, for targets moving toward the side of the lesion, in response to stimuli presented into either visual hemifield. The second deficit, identified in a sixth patient who did not show pursuit asymmetry to predictable targets, was a bidirectional inability to estimate the speed of a moving target in the visual hemifield contralateral to the side of the lesion; this caused inaccurate saccades to moving (but not stationary) targets and impaired smooth pursuit initiation. These visual tracking deficits were independent of homonymous hemianopia or hemispatial neglect. These two tracking deficits are similar to those described in rhesus monkeys with lesions of the medial superior temporal and middle temporal visual areas.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.410230309</identifier><identifier>PMID: 3377449</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Brain Damage, Chronic - physiopathology ; Brain Injuries - physiopathology ; Brain Mapping ; Brain Neoplasms - physiopathology ; Cerebral Cortex - physiopathology ; Cerebral Hemorrhage - physiopathology ; Cerebral Infarction - physiopathology ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Dominance, Cerebral - physiology ; Eye Movements ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Pursuit, Smooth ; Saccades</subject><ispartof>Annals of neurology, 1988-03, Vol.23 (3), p.266-273</ispartof><rights>Copyright © 1988 American Neurological Association</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4139-33bd60bbf162ae04b7b4b1be95ad314a4fc7a353de485127b84387a424617d403</citedby><cites>FETCH-LOGICAL-c4139-33bd60bbf162ae04b7b4b1be95ad314a4fc7a353de485127b84387a424617d403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.410230309$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.410230309$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6983584$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3377449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thurston, Stephen E.</creatorcontrib><creatorcontrib>Leigh, R. John</creatorcontrib><creatorcontrib>Crawford, Trevor</creatorcontrib><creatorcontrib>Thompson, Alan</creatorcontrib><creatorcontrib>Kennard, Christopher</creatorcontrib><title>Two distinct deficits of visual tracking caused by unilateral lesions of cerebral cortex in humans</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>We studied horizontal visual tracking in 20 patients with unilateral cerebral lesions and in 10 age‐matched control subjects. Five patients, all with posterior lesions, showed impaired smooth pursuit of predictable targets moving toward the side of the cerebral lesion. Using nonpredictable step‐ramp stimuli, we identified two distinct deficits of visual tracking. The first was a unidirectional deficit of smooth pursuit, for targets moving toward the side of the lesion, in response to stimuli presented into either visual hemifield. The second deficit, identified in a sixth patient who did not show pursuit asymmetry to predictable targets, was a bidirectional inability to estimate the speed of a moving target in the visual hemifield contralateral to the side of the lesion; this caused inaccurate saccades to moving (but not stationary) targets and impaired smooth pursuit initiation. These visual tracking deficits were independent of homonymous hemianopia or hemispatial neglect. These two tracking deficits are similar to those described in rhesus monkeys with lesions of the medial superior temporal and middle temporal visual areas.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain Damage, Chronic - physiopathology</subject><subject>Brain Injuries - physiopathology</subject><subject>Brain Mapping</subject><subject>Brain Neoplasms - physiopathology</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cerebral Hemorrhage - physiopathology</subject><subject>Cerebral Infarction - physiopathology</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Dominance, Cerebral - physiology</subject><subject>Eye Movements</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Pursuit, Smooth</subject><subject>Saccades</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EKsvCkSOSD4hbip1x4uS4VPRDrYqQikBcrLEzAdOs09oJ7f77ZrvRqqeeLPl9ZvzqMWPvpTiUQuSfMeChkiIHAaJ-wRayAJlVuapfsoWAUmWFBPWavUnpnxCiLqU4YAcAWitVL5i9uut549Pggxt4Q613fki8b_l_n0bs-BDRXfvwhzscEzXcbvgYfIcDxSntKPk-PPKOItntnevjQPfcB_53XGNIb9mrFrtE7-ZzyX4cf706Os0uvp2cHa0uMqck1BmAbUphbSvLHEkoq62y0lJdYANSoWqdRiigIVUVMte2UlBpVLkqpW6UgCX7tNt7E_vbkdJg1j456joM1I_J6K0UyMsJzHagi31KkVpzE_0a48ZIYbZOzeTU7J1O_Id58WjX1OzpWeKUf5xzTA67NmJwPu2xsq6gmMoumd5hd76jzfNvmtXl6mmBufD0T3S_n8R4bUoNujA_L0_Mr9PfX87V8Xcj4QEP4p5m</recordid><startdate>198803</startdate><enddate>198803</enddate><creator>Thurston, Stephen E.</creator><creator>Leigh, R. John</creator><creator>Crawford, Trevor</creator><creator>Thompson, Alan</creator><creator>Kennard, Christopher</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198803</creationdate><title>Two distinct deficits of visual tracking caused by unilateral lesions of cerebral cortex in humans</title><author>Thurston, Stephen E. ; Leigh, R. John ; Crawford, Trevor ; Thompson, Alan ; Kennard, Christopher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4139-33bd60bbf162ae04b7b4b1be95ad314a4fc7a353de485127b84387a424617d403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain Damage, Chronic - physiopathology</topic><topic>Brain Injuries - physiopathology</topic><topic>Brain Mapping</topic><topic>Brain Neoplasms - physiopathology</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Cerebral Hemorrhage - physiopathology</topic><topic>Cerebral Infarction - physiopathology</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Dominance, Cerebral - physiology</topic><topic>Eye Movements</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Pursuit, Smooth</topic><topic>Saccades</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thurston, Stephen E.</creatorcontrib><creatorcontrib>Leigh, R. John</creatorcontrib><creatorcontrib>Crawford, Trevor</creatorcontrib><creatorcontrib>Thompson, Alan</creatorcontrib><creatorcontrib>Kennard, Christopher</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thurston, Stephen E.</au><au>Leigh, R. John</au><au>Crawford, Trevor</au><au>Thompson, Alan</au><au>Kennard, Christopher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two distinct deficits of visual tracking caused by unilateral lesions of cerebral cortex in humans</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1988-03</date><risdate>1988</risdate><volume>23</volume><issue>3</issue><spage>266</spage><epage>273</epage><pages>266-273</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>We studied horizontal visual tracking in 20 patients with unilateral cerebral lesions and in 10 age‐matched control subjects. Five patients, all with posterior lesions, showed impaired smooth pursuit of predictable targets moving toward the side of the cerebral lesion. Using nonpredictable step‐ramp stimuli, we identified two distinct deficits of visual tracking. The first was a unidirectional deficit of smooth pursuit, for targets moving toward the side of the lesion, in response to stimuli presented into either visual hemifield. The second deficit, identified in a sixth patient who did not show pursuit asymmetry to predictable targets, was a bidirectional inability to estimate the speed of a moving target in the visual hemifield contralateral to the side of the lesion; this caused inaccurate saccades to moving (but not stationary) targets and impaired smooth pursuit initiation. These visual tracking deficits were independent of homonymous hemianopia or hemispatial neglect. These two tracking deficits are similar to those described in rhesus monkeys with lesions of the medial superior temporal and middle temporal visual areas.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3377449</pmid><doi>10.1002/ana.410230309</doi><tpages>8</tpages></addata></record> |
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| ispartof | Annals of neurology, 1988-03, Vol.23 (3), p.266-273 |
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| subjects | Adolescent Adult Aged Biological and medical sciences Brain Damage, Chronic - physiopathology Brain Injuries - physiopathology Brain Mapping Brain Neoplasms - physiopathology Cerebral Cortex - physiopathology Cerebral Hemorrhage - physiopathology Cerebral Infarction - physiopathology Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Dominance, Cerebral - physiology Eye Movements Female Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Pursuit, Smooth Saccades |
| title | Two distinct deficits of visual tracking caused by unilateral lesions of cerebral cortex in humans |
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