Changes in collagen metabolism in response to endothelin-1: Evidence for fibroblast heterogeneity

Eudothelin-1 (Et-1) is a 21-amino acid peptide primarily synthesized by endothelial cells. It was originally classified as a potent vasoconstrictor but recent evidence suggests that it also possesses a wide variety of non-vascular actions. It stimulates fibroblast and smooth muscle cell proliferatio...

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