Randomised controlled trial of percutaneous transluminal angioplasty for intermittent claudication
To determine differences between PTA and conventional medical treatment in treadmill distance until onset of claudication, treadmill maximum walking distance, patient reported maximum walking distance, ankle brachial pressure index (ABPI), quality of life (Nottingham Health Profile, NHP) and Duplex...
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| Veröffentlicht in: | European journal of vascular and endovascular surgery 1996-08, Vol.12 (2), p.167-172 |
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| container_title | European journal of vascular and endovascular surgery |
| container_volume | 12 |
| creator | Whyman, M.R. Fowkes, F.G.R. Kerracher, E.M.G. Gillespie, I.N. Lee, A.J. Housley, E. Ruckley, C.V. |
| description | To determine differences between PTA and conventional medical treatment in treadmill distance until onset of claudication, treadmill maximum walking distance, patient reported maximum walking distance, ankle brachial pressure index (ABPI), quality of life (Nottingham Health Profile, NHP) and Duplex measured extent of occlusive disease.
Randomised controlled clinical trial.
Six hundred claudicants were screened. Fifty-one men and 11 women with intermittent claudication due to short femoral stenoses or occlusions (
n = 47) and iliac stenoses (
n = 15) were randomised to either PTA plus medical treatment (PTA group,
n = 30) or to medical treatment alone (control group,
n = 32). Medical treatment consisted of daily low dose aspirin and advice on smoking and exercise.
At 6 month follow up: In the PTA group more patients reported no claudication (
p ≤ 0.05) and were asymptomatic on the treadmill (
p ≤ 0.01) compared to the control group. The ABPI was significantly higher in the PTA group. More of the PTA group reported lower NHP pain scores (
p ≤ 0.05). In the control group there were more occluded arteries (
p ≤ 0.001), and the stenosis velocity ratio of patent arteries was significantly higher (
p ≤ 0.001).
Only 10% of claudicants had discrete lesions suitable for PTA. Treatment of these patients with PTA produces a greater short-term improvement in walking and quality of life than medical treatment alone and is associated with less progression of disease. |
| doi_str_mv | 10.1016/S1078-5884(96)80102-X |
| format | Article |
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Randomised controlled clinical trial.
Six hundred claudicants were screened. Fifty-one men and 11 women with intermittent claudication due to short femoral stenoses or occlusions (
n = 47) and iliac stenoses (
n = 15) were randomised to either PTA plus medical treatment (PTA group,
n = 30) or to medical treatment alone (control group,
n = 32). Medical treatment consisted of daily low dose aspirin and advice on smoking and exercise.
At 6 month follow up: In the PTA group more patients reported no claudication (
p ≤ 0.05) and were asymptomatic on the treadmill (
p ≤ 0.01) compared to the control group. The ABPI was significantly higher in the PTA group. More of the PTA group reported lower NHP pain scores (
p ≤ 0.05). In the control group there were more occluded arteries (
p ≤ 0.001), and the stenosis velocity ratio of patent arteries was significantly higher (
p ≤ 0.001).
Only 10% of claudicants had discrete lesions suitable for PTA. Treatment of these patients with PTA produces a greater short-term improvement in walking and quality of life than medical treatment alone and is associated with less progression of disease.</description><identifier>ISSN: 1078-5884</identifier><identifier>EISSN: 1532-2165</identifier><identifier>DOI: 10.1016/S1078-5884(96)80102-X</identifier><identifier>PMID: 8760978</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Angioplasty ; Angioplasty, Balloon ; Aspirin - therapeutic use ; Blood Pressure - physiology ; Exercise Test ; Exercise Tolerance - physiology ; Female ; Femoral Artery ; Follow-Up Studies ; Humans ; Iliac Artery ; Intermittent claudication ; Intermittent Claudication - physiopathology ; Intermittent Claudication - therapy ; Male ; Middle Aged ; Platelet Aggregation Inhibitors - therapeutic use ; Quality of Life ; Randomised controlled trial ; Time Factors ; Vascular Patency - physiology ; Walking - physiology</subject><ispartof>European journal of vascular and endovascular surgery, 1996-08, Vol.12 (2), p.167-172</ispartof><rights>1996 W. B. Saunders Company Ltd. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-e16b661fcfc41b6bcfbf56a55f06169c754b6bfeaedf57006767a5c55c46a0ec3</citedby><cites>FETCH-LOGICAL-c407t-e16b661fcfc41b6bcfbf56a55f06169c754b6bfeaedf57006767a5c55c46a0ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1078-5884(96)80102-X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8760978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whyman, M.R.</creatorcontrib><creatorcontrib>Fowkes, F.G.R.</creatorcontrib><creatorcontrib>Kerracher, E.M.G.</creatorcontrib><creatorcontrib>Gillespie, I.N.</creatorcontrib><creatorcontrib>Lee, A.J.</creatorcontrib><creatorcontrib>Housley, E.</creatorcontrib><creatorcontrib>Ruckley, C.V.</creatorcontrib><title>Randomised controlled trial of percutaneous transluminal angioplasty for intermittent claudication</title><title>European journal of vascular and endovascular surgery</title><addtitle>Eur J Vasc Endovasc Surg</addtitle><description>To determine differences between PTA and conventional medical treatment in treadmill distance until onset of claudication, treadmill maximum walking distance, patient reported maximum walking distance, ankle brachial pressure index (ABPI), quality of life (Nottingham Health Profile, NHP) and Duplex measured extent of occlusive disease.
Randomised controlled clinical trial.
Six hundred claudicants were screened. Fifty-one men and 11 women with intermittent claudication due to short femoral stenoses or occlusions (
n = 47) and iliac stenoses (
n = 15) were randomised to either PTA plus medical treatment (PTA group,
n = 30) or to medical treatment alone (control group,
n = 32). Medical treatment consisted of daily low dose aspirin and advice on smoking and exercise.
At 6 month follow up: In the PTA group more patients reported no claudication (
p ≤ 0.05) and were asymptomatic on the treadmill (
p ≤ 0.01) compared to the control group. The ABPI was significantly higher in the PTA group. More of the PTA group reported lower NHP pain scores (
p ≤ 0.05). In the control group there were more occluded arteries (
p ≤ 0.001), and the stenosis velocity ratio of patent arteries was significantly higher (
p ≤ 0.001).
Only 10% of claudicants had discrete lesions suitable for PTA. Treatment of these patients with PTA produces a greater short-term improvement in walking and quality of life than medical treatment alone and is associated with less progression of disease.</description><subject>Angioplasty</subject><subject>Angioplasty, Balloon</subject><subject>Aspirin - therapeutic use</subject><subject>Blood Pressure - physiology</subject><subject>Exercise Test</subject><subject>Exercise Tolerance - physiology</subject><subject>Female</subject><subject>Femoral Artery</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Iliac Artery</subject><subject>Intermittent claudication</subject><subject>Intermittent Claudication - physiopathology</subject><subject>Intermittent Claudication - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Quality of Life</subject><subject>Randomised controlled trial</subject><subject>Time Factors</subject><subject>Vascular Patency - physiology</subject><subject>Walking - physiology</subject><issn>1078-5884</issn><issn>1532-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlKBDEQhoMoLqOPIPRJ9NCazHSSnpOIuMGA4ALeQrq6IpF0MiZpwbc3OqNXT1XU_9f2EXLI6CmjTJw9MirbmrdtczwXJy1ldFq_bJBdxmfTesoE3yz5r2WH7KX0RinlbMa3yXYrBZ3Ldpd0D9r3YbAJ-wqCzzE4V9IcrXZVMNUSI4xZewxjKlXtkxsH64uo_asNS6dT_qxMiJX1GeNgc0afK3B67C3obIPfJ1tGu4QH6zghz9dXT5e39eL-5u7yYlFDQ2WukYlOCGbAQMM60YHpDBeac0MFE3OQvClVgxp7wyWlQgqpOXAOjdAUYTYhR6u5yxjeR0xZlbcAnVtdr2Q7bXgrZDHylRFiSCmiUctoBx0_FaPqm636Yau-wam5UD9s1UvpO1wvGLsB-7-uNcyin690LF9-WIwqgUUP2NuIkFUf7D8bvgDqTI1I</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>Whyman, M.R.</creator><creator>Fowkes, F.G.R.</creator><creator>Kerracher, E.M.G.</creator><creator>Gillespie, I.N.</creator><creator>Lee, A.J.</creator><creator>Housley, E.</creator><creator>Ruckley, C.V.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960801</creationdate><title>Randomised controlled trial of percutaneous transluminal angioplasty for intermittent claudication</title><author>Whyman, M.R. ; Fowkes, F.G.R. ; Kerracher, E.M.G. ; Gillespie, I.N. ; Lee, A.J. ; Housley, E. ; Ruckley, C.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-e16b661fcfc41b6bcfbf56a55f06169c754b6bfeaedf57006767a5c55c46a0ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Angioplasty</topic><topic>Angioplasty, Balloon</topic><topic>Aspirin - therapeutic use</topic><topic>Blood Pressure - physiology</topic><topic>Exercise Test</topic><topic>Exercise Tolerance - physiology</topic><topic>Female</topic><topic>Femoral Artery</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Iliac Artery</topic><topic>Intermittent claudication</topic><topic>Intermittent Claudication - physiopathology</topic><topic>Intermittent Claudication - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Quality of Life</topic><topic>Randomised controlled trial</topic><topic>Time Factors</topic><topic>Vascular Patency - physiology</topic><topic>Walking - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whyman, M.R.</creatorcontrib><creatorcontrib>Fowkes, F.G.R.</creatorcontrib><creatorcontrib>Kerracher, E.M.G.</creatorcontrib><creatorcontrib>Gillespie, I.N.</creatorcontrib><creatorcontrib>Lee, A.J.</creatorcontrib><creatorcontrib>Housley, E.</creatorcontrib><creatorcontrib>Ruckley, C.V.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of vascular and endovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whyman, M.R.</au><au>Fowkes, F.G.R.</au><au>Kerracher, E.M.G.</au><au>Gillespie, I.N.</au><au>Lee, A.J.</au><au>Housley, E.</au><au>Ruckley, C.V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Randomised controlled trial of percutaneous transluminal angioplasty for intermittent claudication</atitle><jtitle>European journal of vascular and endovascular surgery</jtitle><addtitle>Eur J Vasc Endovasc Surg</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>12</volume><issue>2</issue><spage>167</spage><epage>172</epage><pages>167-172</pages><issn>1078-5884</issn><eissn>1532-2165</eissn><abstract>To determine differences between PTA and conventional medical treatment in treadmill distance until onset of claudication, treadmill maximum walking distance, patient reported maximum walking distance, ankle brachial pressure index (ABPI), quality of life (Nottingham Health Profile, NHP) and Duplex measured extent of occlusive disease.
Randomised controlled clinical trial.
Six hundred claudicants were screened. Fifty-one men and 11 women with intermittent claudication due to short femoral stenoses or occlusions (
n = 47) and iliac stenoses (
n = 15) were randomised to either PTA plus medical treatment (PTA group,
n = 30) or to medical treatment alone (control group,
n = 32). Medical treatment consisted of daily low dose aspirin and advice on smoking and exercise.
At 6 month follow up: In the PTA group more patients reported no claudication (
p ≤ 0.05) and were asymptomatic on the treadmill (
p ≤ 0.01) compared to the control group. The ABPI was significantly higher in the PTA group. More of the PTA group reported lower NHP pain scores (
p ≤ 0.05). In the control group there were more occluded arteries (
p ≤ 0.001), and the stenosis velocity ratio of patent arteries was significantly higher (
p ≤ 0.001).
Only 10% of claudicants had discrete lesions suitable for PTA. Treatment of these patients with PTA produces a greater short-term improvement in walking and quality of life than medical treatment alone and is associated with less progression of disease.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>8760978</pmid><doi>10.1016/S1078-5884(96)80102-X</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1078-5884 |
| ispartof | European journal of vascular and endovascular surgery, 1996-08, Vol.12 (2), p.167-172 |
| issn | 1078-5884 1532-2165 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78245867 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier) |
| subjects | Angioplasty Angioplasty, Balloon Aspirin - therapeutic use Blood Pressure - physiology Exercise Test Exercise Tolerance - physiology Female Femoral Artery Follow-Up Studies Humans Iliac Artery Intermittent claudication Intermittent Claudication - physiopathology Intermittent Claudication - therapy Male Middle Aged Platelet Aggregation Inhibitors - therapeutic use Quality of Life Randomised controlled trial Time Factors Vascular Patency - physiology Walking - physiology |
| title | Randomised controlled trial of percutaneous transluminal angioplasty for intermittent claudication |
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