Mu-opioid receptor is involved in β-endorphin-induced feeding in goldfish
The present study evaluated the central effects of selective opioid receptor subtype agonists and antagonists on food intake in satiated goldfish. Significant increases in feeding behavior occurred in goldfish injected with β-endorphin, the kappa agonist, U-50488, the delta agonist, [ d-Pen 2, d-Pen...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1996, Vol.17 (3), p.421-424 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | De Pedro, Nuria Céspedes, María Virtudes Delgado, María Jesús Alonso-Bedate, Mercedes |
| description | The present study evaluated the central effects of selective opioid receptor subtype agonists and antagonists on food intake in satiated goldfish. Significant increases in feeding behavior occurred in goldfish injected with β-endorphin, the kappa agonist, U-50488, the delta agonist, [
d-Pen
2,
d-Pen
5]enkephalin (DPEN), and the mu agonist, [
d-Ala
2,
N-Me-Phe
4,Gly
5-ol]enkephalin (DAMGO). On the other hand, the different receptor antagonists used: nor-binaltorphamine (nor-BNI) for kappa, 7-benzidilidenenaltrexone (BNTX) for delta
1, naltriben for delta
2, β-funaltrexamine (β-FNA) for mu, and naloxonazine for mu
1, by themselves, did not modify ingestion or slightly reduced it. The feeding stimulation by β-endorphin was antagonized by β-FNA and naloxonazine, but not by nor-BNI, BNTX, or naltriben. These data indicate that the mu-opioid receptor is involved in the modulation of the feeding behavior in goldfish. |
| doi_str_mv | 10.1016/0196-9781(96)00006-X |
| format | Article |
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2,
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2,
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1, naltriben for delta
2, β-funaltrexamine (β-FNA) for mu, and naloxonazine for mu
1, by themselves, did not modify ingestion or slightly reduced it. The feeding stimulation by β-endorphin was antagonized by β-FNA and naloxonazine, but not by nor-BNI, BNTX, or naltriben. These data indicate that the mu-opioid receptor is involved in the modulation of the feeding behavior in goldfish.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(96)00006-X</identifier><identifier>PMID: 8735968</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; beta-Endorphin - pharmacology ; Carassius auratus ; Delta receptor ; Drug Administration Routes ; Eating - drug effects ; Food intake ; Freshwater ; Goldfish ; Kappa receptor ; Mu receptor ; Opioid antagonists ; Opioid receptors ; Receptors, Opioid, delta - agonists ; Receptors, Opioid, delta - antagonists & inhibitors ; Receptors, Opioid, kappa - agonists ; Receptors, Opioid, kappa - antagonists & inhibitors ; Receptors, Opioid, mu - agonists ; Receptors, Opioid, mu - antagonists & inhibitors ; Receptors, Opioid, mu - metabolism ; β-Endorphin</subject><ispartof>Peptides (New York, N.Y. : 1980), 1996, Vol.17 (3), p.421-424</ispartof><rights>1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-41b0c8b8cc70d6af043ebbbd2f0b59f66e9fa63bb03e007f065c0c2e2502a3c73</citedby><cites>FETCH-LOGICAL-c441t-41b0c8b8cc70d6af043ebbbd2f0b59f66e9fa63bb03e007f065c0c2e2502a3c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(96)00006-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8735968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Pedro, Nuria</creatorcontrib><creatorcontrib>Céspedes, María Virtudes</creatorcontrib><creatorcontrib>Delgado, María Jesús</creatorcontrib><creatorcontrib>Alonso-Bedate, Mercedes</creatorcontrib><title>Mu-opioid receptor is involved in β-endorphin-induced feeding in goldfish</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>The present study evaluated the central effects of selective opioid receptor subtype agonists and antagonists on food intake in satiated goldfish. Significant increases in feeding behavior occurred in goldfish injected with β-endorphin, the kappa agonist, U-50488, the delta agonist, [
d-Pen
2,
d-Pen
5]enkephalin (DPEN), and the mu agonist, [
d-Ala
2,
N-Me-Phe
4,Gly
5-ol]enkephalin (DAMGO). On the other hand, the different receptor antagonists used: nor-binaltorphamine (nor-BNI) for kappa, 7-benzidilidenenaltrexone (BNTX) for delta
1, naltriben for delta
2, β-funaltrexamine (β-FNA) for mu, and naloxonazine for mu
1, by themselves, did not modify ingestion or slightly reduced it. The feeding stimulation by β-endorphin was antagonized by β-FNA and naloxonazine, but not by nor-BNI, BNTX, or naltriben. These data indicate that the mu-opioid receptor is involved in the modulation of the feeding behavior in goldfish.</description><subject>Animals</subject><subject>beta-Endorphin - pharmacology</subject><subject>Carassius auratus</subject><subject>Delta receptor</subject><subject>Drug Administration Routes</subject><subject>Eating - drug effects</subject><subject>Food intake</subject><subject>Freshwater</subject><subject>Goldfish</subject><subject>Kappa receptor</subject><subject>Mu receptor</subject><subject>Opioid antagonists</subject><subject>Opioid receptors</subject><subject>Receptors, Opioid, delta - agonists</subject><subject>Receptors, Opioid, delta - antagonists & inhibitors</subject><subject>Receptors, Opioid, kappa - agonists</subject><subject>Receptors, Opioid, kappa - antagonists & inhibitors</subject><subject>Receptors, Opioid, mu - agonists</subject><subject>Receptors, Opioid, mu - antagonists & inhibitors</subject><subject>Receptors, Opioid, mu - metabolism</subject><subject>β-Endorphin</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1KxDAQx4Moun68gcKeRA_RpE3T5iLI4ieKFwVvoUkmbqTb1KRd8LV8EJ_JrLvsUecyQ_6_mcAPoUNKziih_JxQwbEoK3oi-ClJxfHrBhrRqsxxQbnYRKM1soN2Y3xPDGOi2kbbiSkEr0bo_nHAvnPemXEADV3vw9jFsWvnvpmDScP4-wtDa3zopq7FrjWDTu8WwLj2bZG_-cZYF6f7aMvWTYSDVd9DL9dXz5Nb_PB0cze5fMCaMdpjRhXRlaq0LonhtSUsB6WUySxRhbCcg7A1z5UiORBSWsILTXQGWUGyOtdlvoeOl3e74D8GiL2cuaihaeoW_BBlWWWMsYz-C9JC5EWRVQlkS1AHH2MAK7vgZnX4lJTIhWu5ECkXImXqv67la1o7Wt0f1AzMemklN-UXyxySjbmDIKN20CZ9LrnupfHu7w9-AP64jwk</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>De Pedro, Nuria</creator><creator>Céspedes, María Virtudes</creator><creator>Delgado, María Jesús</creator><creator>Alonso-Bedate, Mercedes</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Mu-opioid receptor is involved in β-endorphin-induced feeding in goldfish</title><author>De Pedro, Nuria ; Céspedes, María Virtudes ; Delgado, María Jesús ; Alonso-Bedate, Mercedes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-41b0c8b8cc70d6af043ebbbd2f0b59f66e9fa63bb03e007f065c0c2e2502a3c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>beta-Endorphin - pharmacology</topic><topic>Carassius auratus</topic><topic>Delta receptor</topic><topic>Drug Administration Routes</topic><topic>Eating - drug effects</topic><topic>Food intake</topic><topic>Freshwater</topic><topic>Goldfish</topic><topic>Kappa receptor</topic><topic>Mu receptor</topic><topic>Opioid antagonists</topic><topic>Opioid receptors</topic><topic>Receptors, Opioid, delta - agonists</topic><topic>Receptors, Opioid, delta - antagonists & inhibitors</topic><topic>Receptors, Opioid, kappa - agonists</topic><topic>Receptors, Opioid, kappa - antagonists & inhibitors</topic><topic>Receptors, Opioid, mu - agonists</topic><topic>Receptors, Opioid, mu - antagonists & inhibitors</topic><topic>Receptors, Opioid, mu - metabolism</topic><topic>β-Endorphin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Pedro, Nuria</creatorcontrib><creatorcontrib>Céspedes, María Virtudes</creatorcontrib><creatorcontrib>Delgado, María Jesús</creatorcontrib><creatorcontrib>Alonso-Bedate, Mercedes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Pedro, Nuria</au><au>Céspedes, María Virtudes</au><au>Delgado, María Jesús</au><au>Alonso-Bedate, Mercedes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mu-opioid receptor is involved in β-endorphin-induced feeding in goldfish</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1996</date><risdate>1996</risdate><volume>17</volume><issue>3</issue><spage>421</spage><epage>424</epage><pages>421-424</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>The present study evaluated the central effects of selective opioid receptor subtype agonists and antagonists on food intake in satiated goldfish. Significant increases in feeding behavior occurred in goldfish injected with β-endorphin, the kappa agonist, U-50488, the delta agonist, [
d-Pen
2,
d-Pen
5]enkephalin (DPEN), and the mu agonist, [
d-Ala
2,
N-Me-Phe
4,Gly
5-ol]enkephalin (DAMGO). On the other hand, the different receptor antagonists used: nor-binaltorphamine (nor-BNI) for kappa, 7-benzidilidenenaltrexone (BNTX) for delta
1, naltriben for delta
2, β-funaltrexamine (β-FNA) for mu, and naloxonazine for mu
1, by themselves, did not modify ingestion or slightly reduced it. The feeding stimulation by β-endorphin was antagonized by β-FNA and naloxonazine, but not by nor-BNI, BNTX, or naltriben. These data indicate that the mu-opioid receptor is involved in the modulation of the feeding behavior in goldfish.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8735968</pmid><doi>10.1016/0196-9781(96)00006-X</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 1996, Vol.17 (3), p.421-424 |
| issn | 0196-9781 1873-5169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78244421 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals beta-Endorphin - pharmacology Carassius auratus Delta receptor Drug Administration Routes Eating - drug effects Food intake Freshwater Goldfish Kappa receptor Mu receptor Opioid antagonists Opioid receptors Receptors, Opioid, delta - agonists Receptors, Opioid, delta - antagonists & inhibitors Receptors, Opioid, kappa - agonists Receptors, Opioid, kappa - antagonists & inhibitors Receptors, Opioid, mu - agonists Receptors, Opioid, mu - antagonists & inhibitors Receptors, Opioid, mu - metabolism β-Endorphin |
| title | Mu-opioid receptor is involved in β-endorphin-induced feeding in goldfish |
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