Peripheral neuropathy in late onset spinocerebellar ataxia
We studied 10 patients with late onset spinocerebellar ataxia including electrophysiological and muscle biopsy examinations. Nerve conduction studies of eight patients revealed axonal neuropathy, and six cases also showed signs of the involvement of the lower motor neuron. In 9 patients quantitative...
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| Veröffentlicht in: | Muscle & nerve 1988-05, Vol.11 (5), p.478-483 |
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| container_title | Muscle & nerve |
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| creator | Nousiainen, Unto Partanen, Juhani Laulumaa, Veikko Paljäurvi, Leo |
| description | We studied 10 patients with late onset spinocerebellar ataxia including electrophysiological and muscle biopsy examinations. Nerve conduction studies of eight patients revealed axonal neuropathy, and six cases also showed signs of the involvement of the lower motor neuron. In 9 patients quantitative analysis of single motor unit potentials (MUPs) of the tibialis anterior or biceps brachii muscles showed mild to severe neuropathic changes and in all 10 patients the histopathological examination of the tibialis anterior showed mild to severe neuropathic changes. Neither nerve conduction studies, quantitative MUP analysis, nor histological findings of the muscle were related to the severity or duration of the disease. |
| doi_str_mv | 10.1002/mus.880110511 |
| format | Article |
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Nerve conduction studies of eight patients revealed axonal neuropathy, and six cases also showed signs of the involvement of the lower motor neuron. In 9 patients quantitative analysis of single motor unit potentials (MUPs) of the tibialis anterior or biceps brachii muscles showed mild to severe neuropathic changes and in all 10 patients the histopathological examination of the tibialis anterior showed mild to severe neuropathic changes. Neither nerve conduction studies, quantitative MUP analysis, nor histological findings of the muscle were related to the severity or duration of the disease.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.880110511</identifier><identifier>PMID: 2836729</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; Biopsy ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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Nerve conduction studies of eight patients revealed axonal neuropathy, and six cases also showed signs of the involvement of the lower motor neuron. In 9 patients quantitative analysis of single motor unit potentials (MUPs) of the tibialis anterior or biceps brachii muscles showed mild to severe neuropathic changes and in all 10 patients the histopathological examination of the tibialis anterior showed mild to severe neuropathic changes. Neither nerve conduction studies, quantitative MUP analysis, nor histological findings of the muscle were related to the severity or duration of the disease.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Electromyography</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Median Nerve - physiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor Neurons - physiology</subject><subject>Muscles - pathology</subject><subject>Neural Conduction</subject><subject>Neurology</subject><subject>Peripheral Nervous System Diseases - diagnosis</subject><subject>Peripheral Nervous System Diseases - etiology</subject><subject>Peroneal Nerve - physiology</subject><subject>Spinocerebellar Degenerations - complications</subject><subject>Ulnar Nerve - physiology</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1P5DAQxS3ECRaOkhIpBaIL2I6_QgcrWJDgQHeHQDTWxDsRhmwS7ESw_z1BG62uumqK95s3bx4h-4weM0r5yaKPx8ZQxqhkbINMGM11KmRuNsmEMmFSleVP22QnxldKKTNKb5EtbjKleT4hp_cYfPuCAaqkxj40LXQvy8TXSQUdJk0dsUti6-vGYcACqwpCAh18evhJfpRQRdwb5y55uLz4O71Kb-5m19Ozm9SJ3LBUiVJCJsE4xTPO0JVzxwUoBtKV2oHTfAgFTgqcF8MbKkPNzDyX3InCsSLbJUcr3zY07z3Gzi58dN9Jamz6aLXhgisjBjBdgS40MQYsbRv8AsLSMmq_u7JDV3bd1cAfjMZ9scD5mh7LGfTDUYfooCoD1M7HNaapUkqaAdMr7MNXuPz_TXv78OffAGNgHzv8XG9CeLNKZ1rax18zS5-vzn_fqks7y74A_ZGRVQ</recordid><startdate>198805</startdate><enddate>198805</enddate><creator>Nousiainen, Unto</creator><creator>Partanen, Juhani</creator><creator>Laulumaa, Veikko</creator><creator>Paljäurvi, Leo</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198805</creationdate><title>Peripheral neuropathy in late onset spinocerebellar ataxia</title><author>Nousiainen, Unto ; Partanen, Juhani ; Laulumaa, Veikko ; Paljäurvi, Leo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4981-64f5a35a8c62321ecfdc24a61a5cf7cac72186ac54edb01163e718d952c4bc1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Electromyography</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Median Nerve - physiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor Neurons - physiology</topic><topic>Muscles - pathology</topic><topic>Neural Conduction</topic><topic>Neurology</topic><topic>Peripheral Nervous System Diseases - diagnosis</topic><topic>Peripheral Nervous System Diseases - etiology</topic><topic>Peroneal Nerve - physiology</topic><topic>Spinocerebellar Degenerations - complications</topic><topic>Ulnar Nerve - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nousiainen, Unto</creatorcontrib><creatorcontrib>Partanen, Juhani</creatorcontrib><creatorcontrib>Laulumaa, Veikko</creatorcontrib><creatorcontrib>Paljäurvi, Leo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nousiainen, Unto</au><au>Partanen, Juhani</au><au>Laulumaa, Veikko</au><au>Paljäurvi, Leo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral neuropathy in late onset spinocerebellar ataxia</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>1988-05</date><risdate>1988</risdate><volume>11</volume><issue>5</issue><spage>478</spage><epage>483</epage><pages>478-483</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>We studied 10 patients with late onset spinocerebellar ataxia including electrophysiological and muscle biopsy examinations. Nerve conduction studies of eight patients revealed axonal neuropathy, and six cases also showed signs of the involvement of the lower motor neuron. In 9 patients quantitative analysis of single motor unit potentials (MUPs) of the tibialis anterior or biceps brachii muscles showed mild to severe neuropathic changes and in all 10 patients the histopathological examination of the tibialis anterior showed mild to severe neuropathic changes. Neither nerve conduction studies, quantitative MUP analysis, nor histological findings of the muscle were related to the severity or duration of the disease.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2836729</pmid><doi>10.1002/mus.880110511</doi><tpages>6</tpages></addata></record> |
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| ispartof | Muscle & nerve, 1988-05, Vol.11 (5), p.478-483 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Biopsy Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electromyography Female Humans Male Median Nerve - physiology Medical sciences Middle Aged Motor Neurons - physiology Muscles - pathology Neural Conduction Neurology Peripheral Nervous System Diseases - diagnosis Peripheral Nervous System Diseases - etiology Peroneal Nerve - physiology Spinocerebellar Degenerations - complications Ulnar Nerve - physiology |
| title | Peripheral neuropathy in late onset spinocerebellar ataxia |
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