The effects of ultraviolet A and reactive oxygen species on the mRNA expression of 72-kDa type IV collagenase and its tissue inhibitor in cultured human dermal fibroblasts

The effects of ultraviolet A (UVA) radiation and reactive oxygen species (ROS), generated with a xanthine and xanthine oxidase (XOD) system, on collagen enzymatic degradation involving the matrix metalloproteinase (MMP) and its tissue inhibitor of metalloproteinase (TIMP) were investigated using cul...

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Veröffentlicht in:	Archives of Dermatological Research 1996, Vol.288 (1), p.39-44
Hauptverfasser:	KAWAGUCHI, Y, TANAKA, H, OKADA, T, KONISHI, H, TAKAHASHI, M, ITO, M, ASAI, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cells, Cultured Collagenases - genetics Fibroblasts - metabolism Fibroblasts - radiation effects Fundamental and applied biological sciences. Psychology Gelatinases - genetics Gene Expression Regulation - radiation effects Humans Matrix Metalloproteinase 1 Matrix Metalloproteinase 2 Metalloendopeptidases - genetics Molecular Weight Proteins - genetics Reactive Oxygen Species - pharmacology RNA, Messenger - analysis Tissue Inhibitor of Metalloproteinase-2 Ultraviolet Rays Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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