An examination of O-2-isocephems as orally absorbable antibiotics

The synthesis and structure-activity relationships of a series of orally absorbed O-2-isocephems are described. These compounds possessed a D-[(p-hydroxyphenyl)glycyl]amino substituent at the 7-position while the substituent at the 3-position was varied. Relative to the analogous cephems, the O-2-is...

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Veröffentlicht in:	Journal of medicinal chemistry 1988-06, Vol.31 (6), p.1190-1196
Hauptverfasser:	Mastalerz, Harold, Menard, Marcel, Vinet, Vivianne, Desiderio, James, Fung-Tomc, Joan, Kessler, Robert, Tsai, Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Cephalosporins - chemical synthesis Cephalosporins - pharmacokinetics Cephalosporins - pharmacology Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Microbial Sensitivity Tests Organic chemistry Preparations and properties Structure-Activity Relationship
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