Stimulation of B-cell progenitors by cloned murine interleukin-7
The events involved in the commitment and development of lymphoid lineage cells are poorly understood. We have used a recently described long-term culture system to establish a bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors. Using dire...
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| Veröffentlicht in: | Nature (London) 1988-06, Vol.333 (6173), p.571-572 |
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| creator | NAMEN, A. E LUPTON, S COSMAN, D GOODWIN, R. G HJERRILD, K WIGNALL, J MOCHIZUKI, D. Y SCHMIERER, A MOSLEY, B MARCH, C. J URDAL, D GILLIS, S |
| description | The events involved in the commitment and development of lymphoid lineage cells are poorly understood. We have used a recently described long-term culture system to establish a bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors. Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7. |
| doi_str_mv | 10.1038/333571a0 |
| format | Article |
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E ; LUPTON, S ; COSMAN, D ; GOODWIN, R. G ; HJERRILD, K ; WIGNALL, J ; MOCHIZUKI, D. Y ; SCHMIERER, A ; MOSLEY, B ; MARCH, C. J ; URDAL, D ; GILLIS, S</creator><creatorcontrib>NAMEN, A. E ; LUPTON, S ; COSMAN, D ; GOODWIN, R. G ; HJERRILD, K ; WIGNALL, J ; MOCHIZUKI, D. Y ; SCHMIERER, A ; MOSLEY, B ; MARCH, C. J ; URDAL, D ; GILLIS, S</creatorcontrib><description>The events involved in the commitment and development of lymphoid lineage cells are poorly understood. We have used a recently described long-term culture system to establish a bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors. Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/333571a0</identifier><identifier>PMID: 3259677</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Amino Acid Sequence ; Analytical, structural and metabolic biochemistry ; Animals ; B-Lymphocytes - cytology ; Base Sequence ; Bioassays ; Biochemistry ; Biological and medical sciences ; Cell Differentiation - drug effects ; Cloning, Molecular ; DNA - genetics ; Fundamental and applied biological sciences. Psychology ; Immunity (Disease) ; Interleukin-7 ; Interleukins - genetics ; Interleukins - pharmacology ; Mice ; Molecular Sequence Data ; Protein hormones. Growth factors. Cytokines ; Proteins ; RNA, Messenger - genetics</subject><ispartof>Nature (London), 1988-06, Vol.333 (6173), p.571-572</ispartof><rights>1988 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. 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G</creatorcontrib><creatorcontrib>HJERRILD, K</creatorcontrib><creatorcontrib>WIGNALL, J</creatorcontrib><creatorcontrib>MOCHIZUKI, D. Y</creatorcontrib><creatorcontrib>SCHMIERER, A</creatorcontrib><creatorcontrib>MOSLEY, B</creatorcontrib><creatorcontrib>MARCH, C. J</creatorcontrib><creatorcontrib>URDAL, D</creatorcontrib><creatorcontrib>GILLIS, S</creatorcontrib><title>Stimulation of B-cell progenitors by cloned murine interleukin-7</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>The events involved in the commitment and development of lymphoid lineage cells are poorly understood. We have used a recently described long-term culture system to establish a bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors. Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7.</description><subject>Amino Acid Sequence</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>B-Lymphocytes - cytology</subject><subject>Base Sequence</subject><subject>Bioassays</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - drug effects</subject><subject>Cloning, Molecular</subject><subject>DNA - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunity (Disease)</subject><subject>Interleukin-7</subject><subject>Interleukins - genetics</subject><subject>Interleukins - pharmacology</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Protein hormones. Growth factors. 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E ; LUPTON, S ; COSMAN, D ; GOODWIN, R. G ; HJERRILD, K ; WIGNALL, J ; MOCHIZUKI, D. Y ; SCHMIERER, A ; MOSLEY, B ; MARCH, C. J ; URDAL, D ; GILLIS, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-ee689ee4d084f9f5526cc5b4404e527010b9be0c87cd8865ff2b352463f78da83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amino Acid Sequence</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>B-Lymphocytes - cytology</topic><topic>Base Sequence</topic><topic>Bioassays</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - drug effects</topic><topic>Cloning, Molecular</topic><topic>DNA - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunity (Disease)</topic><topic>Interleukin-7</topic><topic>Interleukins - genetics</topic><topic>Interleukins - pharmacology</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Protein hormones. Growth factors. Cytokines</topic><topic>Proteins</topic><topic>RNA, Messenger - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAMEN, A. E</creatorcontrib><creatorcontrib>LUPTON, S</creatorcontrib><creatorcontrib>COSMAN, D</creatorcontrib><creatorcontrib>GOODWIN, R. G</creatorcontrib><creatorcontrib>HJERRILD, K</creatorcontrib><creatorcontrib>WIGNALL, J</creatorcontrib><creatorcontrib>MOCHIZUKI, D. Y</creatorcontrib><creatorcontrib>SCHMIERER, A</creatorcontrib><creatorcontrib>MOSLEY, B</creatorcontrib><creatorcontrib>MARCH, C. 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Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>3259677</pmid><doi>10.1038/333571a0</doi><tpages>2</tpages></addata></record> |
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| ispartof | Nature (London), 1988-06, Vol.333 (6173), p.571-572 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals B-Lymphocytes - cytology Base Sequence Bioassays Biochemistry Biological and medical sciences Cell Differentiation - drug effects Cloning, Molecular DNA - genetics Fundamental and applied biological sciences. Psychology Immunity (Disease) Interleukin-7 Interleukins - genetics Interleukins - pharmacology Mice Molecular Sequence Data Protein hormones. Growth factors. Cytokines Proteins RNA, Messenger - genetics |
| title | Stimulation of B-cell progenitors by cloned murine interleukin-7 |
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