Quantification of cardiovascular instability in premature infants using spectral analysis of waveforms
Spectral analysis was applied to blood pressure and cerebral blood flow velocity recordings in premature infants with respiratory distress in order to quantify respiration-induced cardiovascular variability. Aortic blood pressure was transduced via an umbilical arterial catheter and cerebral blood f...
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| Veröffentlicht in: | Pediatric research 1988-04, Vol.23 (4), p.398-401 |
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| container_issue | 4 |
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| container_title | Pediatric research |
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| creator | BIGNALL, S BAILEY, P. C RIVERS, R. P. A LISSAUER, T. J |
| description | Spectral analysis was applied to blood pressure and cerebral blood flow velocity recordings in premature infants with respiratory distress in order to quantify respiration-induced cardiovascular variability. Aortic blood pressure was transduced via an umbilical arterial catheter and cerebral blood flow velocity measured in the anterior cerebral artery using a 10 MHz continuous wave Doppler velocimeter in 16 infants less than or equal to 32 wk gestational age. Spectral analysis of the resulting waveforms revealed heart rate and respiratory rate components whose relative amplitudes (heart rate/respiratory rate amplitude ratio) represent an index of that component of variability induced by respiratory events. The mean (heart rate/respiratory rate amplitude) ratio was 47.2 in spontaneously breathing infants and rose to 165.9 in infants who were ventilated during muscle paralysis (p = 0.0003). Cerebral blood flow velocity recordings showed R components in only 22 of 38 simultaneous recordings. This method can be used to quantify respiration-induced cardiovascular variability and its response to therapy, and may provide a means of identifying infants at risk from brain injury due to an inability to regulate cerebral blood flow. |
| doi_str_mv | 10.1203/00006450-198804000-00012 |
| format | Article |
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The mean (heart rate/respiratory rate amplitude) ratio was 47.2 in spontaneously breathing infants and rose to 165.9 in infants who were ventilated during muscle paralysis (p = 0.0003). Cerebral blood flow velocity recordings showed R components in only 22 of 38 simultaneous recordings. This method can be used to quantify respiration-induced cardiovascular variability and its response to therapy, and may provide a means of identifying infants at risk from brain injury due to an inability to regulate cerebral blood flow.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/00006450-198804000-00012</identifier><identifier>PMID: 3374993</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Flow Velocity ; Blood Pressure ; Brain - blood supply ; Cardiovascular Physiological Phenomena ; Emergency and intensive care: neonates and children. Prematurity. 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C</creatorcontrib><creatorcontrib>RIVERS, R. P. A</creatorcontrib><creatorcontrib>LISSAUER, T. J</creatorcontrib><title>Quantification of cardiovascular instability in premature infants using spectral analysis of waveforms</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><description>Spectral analysis was applied to blood pressure and cerebral blood flow velocity recordings in premature infants with respiratory distress in order to quantify respiration-induced cardiovascular variability. Aortic blood pressure was transduced via an umbilical arterial catheter and cerebral blood flow velocity measured in the anterior cerebral artery using a 10 MHz continuous wave Doppler velocimeter in 16 infants less than or equal to 32 wk gestational age. Spectral analysis of the resulting waveforms revealed heart rate and respiratory rate components whose relative amplitudes (heart rate/respiratory rate amplitude ratio) represent an index of that component of variability induced by respiratory events. The mean (heart rate/respiratory rate amplitude) ratio was 47.2 in spontaneously breathing infants and rose to 165.9 in infants who were ventilated during muscle paralysis (p = 0.0003). Cerebral blood flow velocity recordings showed R components in only 22 of 38 simultaneous recordings. This method can be used to quantify respiration-induced cardiovascular variability and its response to therapy, and may provide a means of identifying infants at risk from brain injury due to an inability to regulate cerebral blood flow.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Blood Pressure</subject><subject>Brain - blood supply</subject><subject>Cardiovascular Physiological Phenomena</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Gestational Age</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - physiology</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Microcomputers</subject><subject>Respiratory Insufficiency - physiopathology</subject><subject>Spectrum Analysis</subject><subject>Transducers, Pressure</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kFtLAzEQhYMotVZ_grAP4ttqrpvNoxRvUBBBn5fZbCKRvdTMbqX_3mhrA0PmMOfMwEdIxugN41Tc0vQKqWjOTFlSmVSeivEjMmdKJCGlPiZzSgXLhTHlKTlD_EwOqUo5IzMhtDRGzIl_naAfgw8WxjD02eAzC7EJwwbQTi3ELPQ4Qh3aMG5Tn62j62CcokvCpyhmE4b-I8O1s2OENoMe2i0G_F31DRvnh9jhOTnx0KK72P8L8v5w_7Z8ylcvj8_Lu1VuRWnGnDtDpS98A6w2hTJQF1QrBhYULzh1XNbaNVpqY5payaJmtqG6lKpuuIQEZkGud3vXcfiaHI5VF9C6toXeDRNWuuTCSMmTsdwZbRwQo_PVOoYO4rZitPpFXP0jrg6Iqz_EKXq5vzHVnWsOwT3TNL_azxNCaH2E3gY82HRBuVaF-AEUFoWK</recordid><startdate>19880401</startdate><enddate>19880401</enddate><creator>BIGNALL, S</creator><creator>BAILEY, P. 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Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Blood Pressure</topic><topic>Brain - blood supply</topic><topic>Cardiovascular Physiological Phenomena</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Gestational Age</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - physiology</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Microcomputers</topic><topic>Respiratory Insufficiency - physiopathology</topic><topic>Spectrum Analysis</topic><topic>Transducers, Pressure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BIGNALL, S</creatorcontrib><creatorcontrib>BAILEY, P. C</creatorcontrib><creatorcontrib>RIVERS, R. P. A</creatorcontrib><creatorcontrib>LISSAUER, T. 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of cardiovascular instability in premature infants using spectral analysis of waveforms</atitle><jtitle>Pediatric research</jtitle><addtitle>Pediatr Res</addtitle><date>1988-04-01</date><risdate>1988</risdate><volume>23</volume><issue>4</issue><spage>398</spage><epage>401</epage><pages>398-401</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>Spectral analysis was applied to blood pressure and cerebral blood flow velocity recordings in premature infants with respiratory distress in order to quantify respiration-induced cardiovascular variability. Aortic blood pressure was transduced via an umbilical arterial catheter and cerebral blood flow velocity measured in the anterior cerebral artery using a 10 MHz continuous wave Doppler velocimeter in 16 infants less than or equal to 32 wk gestational age. Spectral analysis of the resulting waveforms revealed heart rate and respiratory rate components whose relative amplitudes (heart rate/respiratory rate amplitude ratio) represent an index of that component of variability induced by respiratory events. The mean (heart rate/respiratory rate amplitude) ratio was 47.2 in spontaneously breathing infants and rose to 165.9 in infants who were ventilated during muscle paralysis (p = 0.0003). Cerebral blood flow velocity recordings showed R components in only 22 of 38 simultaneous recordings. This method can be used to quantify respiration-induced cardiovascular variability and its response to therapy, and may provide a means of identifying infants at risk from brain injury due to an inability to regulate cerebral blood flow.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>3374993</pmid><doi>10.1203/00006450-198804000-00012</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 1988-04, Vol.23 (4), p.398-401 |
| issn | 0031-3998 1530-0447 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78239442 |
| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Flow Velocity Blood Pressure Brain - blood supply Cardiovascular Physiological Phenomena Emergency and intensive care: neonates and children. Prematurity. Sudden death Gestational Age Heart Rate Humans Infant, Newborn Infant, Premature - physiology Intensive care medicine Medical sciences Microcomputers Respiratory Insufficiency - physiopathology Spectrum Analysis Transducers, Pressure |
| title | Quantification of cardiovascular instability in premature infants using spectral analysis of waveforms |
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