Protoberberine alkaloids as antimalarials

The protoberberine alkaloids berberine (1), palmatine (2), jatrorrhizine (3), and several berberine derivatives (4-10) were tested for antimalarial activity in vitro against Plasmodium falciparum and in vivo against Plasmodium berghei. The berberine derivatives 4-10 were designed and synthesized to...

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Veröffentlicht in:	Journal of medicinal chemistry 1988-06, Vol.31 (6), p.1084-1087
Hauptverfasser:	Vennerstrom, Jonathan L, Klayman, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - chemical synthesis Antimalarials - pharmacology Antiparasitic agents Berberine - analogs & derivatives Berberine - pharmacology Berberine Alkaloids - pharmacology Biological and medical sciences Medical sciences Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - drug effects
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