Tumor Necrosis Factor Not Detectable in Patients With Clinical Cancer Cachexia
Tumor necrosis factor (TNF) has been implicated in the pathogenesis of cachexia in neoplastic and infectious diseases. To assess the relationship between TNF and weight loss among cancer patients, we assayed TNF levels in serum from 19 patients who had lost 8%–40% of premorbid weight. The weight los...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1988-06, Vol.80 (8), p.595-598 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | Socher, Susan H. Martinez, Douglas Craig, John B. Kuhn, John G. Oliff, Allen |
| description | Tumor necrosis factor (TNF) has been implicated in the pathogenesis of cachexia in neoplastic and infectious diseases. To assess the relationship between TNF and weight loss among cancer patients, we assayed TNF levels in serum from 19 patients who had lost 8%–40% of premorbid weight. The weight loss experienced by these patients was not attributable to anticancer therapy, gastrointestinal disorders, or other medical problems. TNF was measured using a quantitative sandwich enzyme-linked immunosorbent assay that is sensitive to human TNF in serum at concentrations ≥40 pg/mL. No TNF was detected in serum samples from the 19 patients studied. |
| doi_str_mv | 10.1093/jnci/80.8.595 |
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To assess the relationship between TNF and weight loss among cancer patients, we assayed TNF levels in serum from 19 patients who had lost 8%–40% of premorbid weight. The weight loss experienced by these patients was not attributable to anticancer therapy, gastrointestinal disorders, or other medical problems. TNF was measured using a quantitative sandwich enzyme-linked immunosorbent assay that is sensitive to human TNF in serum at concentrations ≥40 pg/mL. No TNF was detected in serum samples from the 19 patients studied.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/80.8.595</identifier><identifier>PMID: 3373550</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Body Weight ; Cachexia - blood ; Cachexia - etiology ; Enzyme-Linked Immunosorbent Assay ; Host-tumor relations. Immunology. 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To assess the relationship between TNF and weight loss among cancer patients, we assayed TNF levels in serum from 19 patients who had lost 8%–40% of premorbid weight. The weight loss experienced by these patients was not attributable to anticancer therapy, gastrointestinal disorders, or other medical problems. TNF was measured using a quantitative sandwich enzyme-linked immunosorbent assay that is sensitive to human TNF in serum at concentrations ≥40 pg/mL. No TNF was detected in serum samples from the 19 patients studied.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Cachexia - blood</subject><subject>Cachexia - etiology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Host-tumor relations. Immunology. Biological markers</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms - blood</subject><subject>Neoplasms - complications</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumors</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1P4zAQxa0VCArskSNSDmhvKf6M7SOELQVV3T2AFu3FcpyJMKQJ2K4E_z2uqMocZjR6P83oPYROCZ4SrNnF8-D8hcJTNRVa_EATwitcUoLFHppgTGWplOSH6CjGZ5xLU36ADhiTTAg8Qcv79WoMxRJcGKOPxcy6tNnHVFxDApds00Phh-KvTR6GFIt_Pj0Vde8H72xf1HZwEPJwT_Du7Qna72wf4ed2HqOH2e_7el4u_tzc1peL0uW3qeTEtSo3yyUm4KpGSdZJTpVtK-iornjDNLW8E8p1imCoOG6dbrXm0FQtYcfo19fd1zC-rSEms_LRQd_bAcZ1NFJRxqmmGSy_wI2_GKAzr8GvbPgwBJtNfmaTn1HYKJPzy_zZ9vC6WUG7o7eBZf18q9uY_Xch-_dxh0lJmOD8-62PCd53sg0vppJMCjN__G_q-d2VfBTCzNgnMJiG-g</recordid><startdate>19880615</startdate><enddate>19880615</enddate><creator>Socher, Susan H.</creator><creator>Martinez, Douglas</creator><creator>Craig, John B.</creator><creator>Kuhn, John G.</creator><creator>Oliff, Allen</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880615</creationdate><title>Tumor Necrosis Factor Not Detectable in Patients With Clinical Cancer Cachexia</title><author>Socher, Susan H. ; Martinez, Douglas ; Craig, John B. ; Kuhn, John G. ; Oliff, Allen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-41cd841ca4701ec6b873f7428ad6ef2964b392a4f58cf810e640dc9d994eb6d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Cachexia - blood</topic><topic>Cachexia - etiology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Host-tumor relations. 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Biological markers</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms - blood</topic><topic>Neoplasms - complications</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Socher, Susan H.</creatorcontrib><creatorcontrib>Martinez, Douglas</creatorcontrib><creatorcontrib>Craig, John B.</creatorcontrib><creatorcontrib>Kuhn, John G.</creatorcontrib><creatorcontrib>Oliff, Allen</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Socher, Susan H.</au><au>Martinez, Douglas</au><au>Craig, John B.</au><au>Kuhn, John G.</au><au>Oliff, Allen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor Necrosis Factor Not Detectable in Patients With Clinical Cancer Cachexia</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>1988-06-15</date><risdate>1988</risdate><volume>80</volume><issue>8</issue><spage>595</spage><epage>598</epage><pages>595-598</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>Tumor necrosis factor (TNF) has been implicated in the pathogenesis of cachexia in neoplastic and infectious diseases. 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| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1988-06, Vol.80 (8), p.595-598 |
| issn | 0027-8874 1460-2105 |
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| source | MEDLINE; Oxford journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Body Weight Cachexia - blood Cachexia - etiology Enzyme-Linked Immunosorbent Assay Host-tumor relations. Immunology. Biological markers Humans Medical sciences Middle Aged Neoplasms - blood Neoplasms - complications Tumor Necrosis Factor-alpha - blood Tumors |
| title | Tumor Necrosis Factor Not Detectable in Patients With Clinical Cancer Cachexia |
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