Transmission of Genital Herpes in Couples with One Symptomatic and One Asymptomatic Partner: A Prospective Study
To determine the risk of transmission of genital herpes simplex virus (HSV) infection, we prospectively studied, for a median of six months, 38 couples who had been together for a median of 10 mo. In each couple, one partner had a history of symptomatic genital herpes and one did not. At entry, of t...
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| Veröffentlicht in: | The Journal of infectious diseases 1988-06, Vol.157 (6), p.1169-1177 |
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| container_title | The Journal of infectious diseases |
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| creator | Mertz, Gregory J. Coombs, Robert W. Ashley, Rhoda Jourden, John Remington, Michael Winter, Carol Fahnlander, Anita Guinan, Mary Ducey, Hanna Corey, Lawrence |
| description | To determine the risk of transmission of genital herpes simplex virus (HSV) infection, we prospectively studied, for a median of six months, 38 couples who had been together for a median of 10 mo. In each couple, one partner had a history of symptomatic genital herpes and one did not. At entry, of the 38 asymptomatic, exposed partners, 21 were seronegative, and results of western blot analysis showed that seven had antibody to HSV type 1 (HSV-1), four to HSV type 2 (HSV-2), and six to both HSV-1 and HSV-2. One of the 28 exposed partners without antibody to HSV-2 at enrollment asymptomatically acquired HSV-2 infection, but four of 10 with antibody to HSV-2 at enrollment developed culture-proven HSV-2 infection during follow-up. Restriction endonuclease analysis of DNA from paired isolates revealed identical strains in three couples and different strains in one. In this group of asymptomatic sex partners of persons with genital herpes, asymptomatic and unrecognized acquisition of HSV-2 infection was common, but more than half of the exposed partners remained free of HSV-2 infection after a median of 16 mo of sexual contact. |
| doi_str_mv | 10.1093/infdis/157.6.1169 |
| format | Article |
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In each couple, one partner had a history of symptomatic genital herpes and one did not. At entry, of the 38 asymptomatic, exposed partners, 21 were seronegative, and results of western blot analysis showed that seven had antibody to HSV type 1 (HSV-1), four to HSV type 2 (HSV-2), and six to both HSV-1 and HSV-2. One of the 28 exposed partners without antibody to HSV-2 at enrollment asymptomatically acquired HSV-2 infection, but four of 10 with antibody to HSV-2 at enrollment developed culture-proven HSV-2 infection during follow-up. Restriction endonuclease analysis of DNA from paired isolates revealed identical strains in three couples and different strains in one. In this group of asymptomatic sex partners of persons with genital herpes, asymptomatic and unrecognized acquisition of HSV-2 infection was common, but more than half of the exposed partners remained free of HSV-2 infection after a median of 16 mo of sexual contact.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/157.6.1169</identifier><identifier>PMID: 2836518</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Antibodies ; Antibodies, Viral - analysis ; Biological and medical sciences ; Disease transmission ; DNA Restriction Enzymes ; DNA, Viral - analysis ; Female ; Genital herpes ; Genitalia ; Herpes Genitalis - transmission ; Human herpesvirus 1 ; Human herpesvirus 2 ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; Lesions ; Male ; Medical sciences ; Original Articles ; Prospective Studies ; Recurrence ; Sexually Transmitted Diseases - transmission ; Simplexvirus ; Simplexvirus - classification ; Simplexvirus - genetics ; Simplexvirus - immunology ; Time Factors ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye ; Viruses</subject><ispartof>The Journal of infectious diseases, 1988-06, Vol.157 (6), p.1169-1177</ispartof><rights>Copyright 1988 The University of Chicago</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-63fe42466f74a4abf1a9eb48e7f51f5514f7177acdc7fdc60731832efc5afca43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30135745$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30135745$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,27911,27912,58004,58237</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7743322$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2836518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mertz, Gregory J.</creatorcontrib><creatorcontrib>Coombs, Robert W.</creatorcontrib><creatorcontrib>Ashley, Rhoda</creatorcontrib><creatorcontrib>Jourden, John</creatorcontrib><creatorcontrib>Remington, Michael</creatorcontrib><creatorcontrib>Winter, Carol</creatorcontrib><creatorcontrib>Fahnlander, Anita</creatorcontrib><creatorcontrib>Guinan, Mary</creatorcontrib><creatorcontrib>Ducey, Hanna</creatorcontrib><creatorcontrib>Corey, Lawrence</creatorcontrib><title>Transmission of Genital Herpes in Couples with One Symptomatic and One Asymptomatic Partner: A Prospective Study</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>To determine the risk of transmission of genital herpes simplex virus (HSV) infection, we prospectively studied, for a median of six months, 38 couples who had been together for a median of 10 mo. In each couple, one partner had a history of symptomatic genital herpes and one did not. At entry, of the 38 asymptomatic, exposed partners, 21 were seronegative, and results of western blot analysis showed that seven had antibody to HSV type 1 (HSV-1), four to HSV type 2 (HSV-2), and six to both HSV-1 and HSV-2. One of the 28 exposed partners without antibody to HSV-2 at enrollment asymptomatically acquired HSV-2 infection, but four of 10 with antibody to HSV-2 at enrollment developed culture-proven HSV-2 infection during follow-up. Restriction endonuclease analysis of DNA from paired isolates revealed identical strains in three couples and different strains in one. In this group of asymptomatic sex partners of persons with genital herpes, asymptomatic and unrecognized acquisition of HSV-2 infection was common, but more than half of the exposed partners remained free of HSV-2 infection after a median of 16 mo of sexual contact.</description><subject>Adult</subject><subject>Antibodies</subject><subject>Antibodies, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>Disease transmission</subject><subject>DNA Restriction Enzymes</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>Genital herpes</subject><subject>Genitalia</subject><subject>Herpes Genitalis - transmission</subject><subject>Human herpesvirus 1</subject><subject>Human herpesvirus 2</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lesions</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Original Articles</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Sexually Transmitted Diseases - transmission</subject><subject>Simplexvirus</subject><subject>Simplexvirus - classification</subject><subject>Simplexvirus - genetics</subject><subject>Simplexvirus - immunology</subject><subject>Time Factors</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhS1EVdLCD2CB5AViN6nv-DXDLopoglq1lSgIsbEcjy1c5lXbA82_x21CYMfK1v3OOdK9B6HXQOZAanrme9f4eAZczsUcQNTP0Aw4lYUQQJ-jGSFlWUBV1y_QSYx3hBBGhTxGx2VFBYdqhsbboPvY-Rj90OPB4ZXtfdItXtsw2oh9j5fDNLb5-8un7_i6t_jTthvT0OnkDdZ98zRbxH-GNzqk3ob3eIFvwhBHa5L_mX1parYv0ZHTbbSv9u8p-nz-4Xa5Li6vVx-Xi8vCMBCpENRZVjIhnGSa6Y0DXdsNq6x0HBznwJwEKbVpjHSNEURSqGhpneHaGc3oKXq3yx3DcD_ZmFRe0ti21b0dpqhkVVIGNfmvMN-zJpyLLISd0OSdYrBOjcF3OmwVEPVYh9rVkR1SCfVYR_a82YdPm842B8f-_pm_3XMdjW5dLsPkhD8yKRmlZfk35i6mIRwwJUC5ZDzzYsd9TPbhwHX4oYSkkqv112_q4nzFCflypST9DTqVrjw</recordid><startdate>19880601</startdate><enddate>19880601</enddate><creator>Mertz, Gregory J.</creator><creator>Coombs, Robert W.</creator><creator>Ashley, Rhoda</creator><creator>Jourden, John</creator><creator>Remington, Michael</creator><creator>Winter, Carol</creator><creator>Fahnlander, Anita</creator><creator>Guinan, Mary</creator><creator>Ducey, Hanna</creator><creator>Corey, Lawrence</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19880601</creationdate><title>Transmission of Genital Herpes in Couples with One Symptomatic and One Asymptomatic Partner: A Prospective Study</title><author>Mertz, Gregory J. ; Coombs, Robert W. ; Ashley, Rhoda ; Jourden, John ; Remington, Michael ; Winter, Carol ; Fahnlander, Anita ; Guinan, Mary ; Ducey, Hanna ; Corey, Lawrence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-63fe42466f74a4abf1a9eb48e7f51f5514f7177acdc7fdc60731832efc5afca43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Antibodies</topic><topic>Antibodies, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>Disease transmission</topic><topic>DNA Restriction Enzymes</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>Genital herpes</topic><topic>Genitalia</topic><topic>Herpes Genitalis - transmission</topic><topic>Human herpesvirus 1</topic><topic>Human herpesvirus 2</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lesions</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Original Articles</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Sexually Transmitted Diseases - transmission</topic><topic>Simplexvirus</topic><topic>Simplexvirus - classification</topic><topic>Simplexvirus - genetics</topic><topic>Simplexvirus - immunology</topic><topic>Time Factors</topic><topic>Viral diseases</topic><topic>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mertz, Gregory J.</creatorcontrib><creatorcontrib>Coombs, Robert W.</creatorcontrib><creatorcontrib>Ashley, Rhoda</creatorcontrib><creatorcontrib>Jourden, John</creatorcontrib><creatorcontrib>Remington, Michael</creatorcontrib><creatorcontrib>Winter, Carol</creatorcontrib><creatorcontrib>Fahnlander, Anita</creatorcontrib><creatorcontrib>Guinan, Mary</creatorcontrib><creatorcontrib>Ducey, Hanna</creatorcontrib><creatorcontrib>Corey, Lawrence</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mertz, Gregory J.</au><au>Coombs, Robert W.</au><au>Ashley, Rhoda</au><au>Jourden, John</au><au>Remington, Michael</au><au>Winter, Carol</au><au>Fahnlander, Anita</au><au>Guinan, Mary</au><au>Ducey, Hanna</au><au>Corey, Lawrence</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmission of Genital Herpes in Couples with One Symptomatic and One Asymptomatic Partner: A Prospective Study</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1988-06-01</date><risdate>1988</risdate><volume>157</volume><issue>6</issue><spage>1169</spage><epage>1177</epage><pages>1169-1177</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To determine the risk of transmission of genital herpes simplex virus (HSV) infection, we prospectively studied, for a median of six months, 38 couples who had been together for a median of 10 mo. In each couple, one partner had a history of symptomatic genital herpes and one did not. At entry, of the 38 asymptomatic, exposed partners, 21 were seronegative, and results of western blot analysis showed that seven had antibody to HSV type 1 (HSV-1), four to HSV type 2 (HSV-2), and six to both HSV-1 and HSV-2. One of the 28 exposed partners without antibody to HSV-2 at enrollment asymptomatically acquired HSV-2 infection, but four of 10 with antibody to HSV-2 at enrollment developed culture-proven HSV-2 infection during follow-up. Restriction endonuclease analysis of DNA from paired isolates revealed identical strains in three couples and different strains in one. In this group of asymptomatic sex partners of persons with genital herpes, asymptomatic and unrecognized acquisition of HSV-2 infection was common, but more than half of the exposed partners remained free of HSV-2 infection after a median of 16 mo of sexual contact.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>2836518</pmid><doi>10.1093/infdis/157.6.1169</doi><tpages>9</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1988-06, Vol.157 (6), p.1169-1177 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Adult Antibodies Antibodies, Viral - analysis Biological and medical sciences Disease transmission DNA Restriction Enzymes DNA, Viral - analysis Female Genital herpes Genitalia Herpes Genitalis - transmission Human herpesvirus 1 Human herpesvirus 2 Human viral diseases Humans Infections Infectious diseases Lesions Male Medical sciences Original Articles Prospective Studies Recurrence Sexually Transmitted Diseases - transmission Simplexvirus Simplexvirus - classification Simplexvirus - genetics Simplexvirus - immunology Time Factors Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye Viruses |
| title | Transmission of Genital Herpes in Couples with One Symptomatic and One Asymptomatic Partner: A Prospective Study |
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