Sulfonated dextran inhibits complement activation and complement-dependent cytotoxicity in an in vitro model of hyperacute xenograft rejection

In the present study, we demonstrate that a substituted soluble dextran derivative bearing 73% carboxylic groups and 15% benzylamide sulfonate groups, termed CMDBS25, inhibits complement activation and complement-mediated damage in an in vitro model of xenogeneic rejection. Incubation of porcine aor...

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Veröffentlicht in:	Molecular immunology 1996-05, Vol.33 (7), p.643-648
Hauptverfasser:	Thomas, Helene, Maillet, Francoise, Letourneur, Didier, Jozefonvicz, Jacqueline, Fischer, Elizabeth, Kazatchkine, Michel D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Cells, Cultured complement Complement Activation - drug effects Complement C3 - metabolism Complement C5 - metabolism Complement Inactivator Proteins - pharmacology Complement Membrane Attack Complex - metabolism Cytotoxicity, Immunologic - drug effects Dextrans - pharmacology Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Graft Rejection - immunology Humans Models, Immunological polymers sulfated dextran Swine Transplantation, Heterologous - immunology xenogeneic model
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