Effects of phencyclidine metabolites on serotonin uptake in rat brain

The effects of phencyclidine (PCP) and its metabolites on serotonin (5-hydroxytryptamine, 5-HT) receptors were studied. PCP and its metabolites inhibited the uptake of [ 3H]5-HT and the binding of [ 3H]paroxetine in rat brain, while they failed to inhibit either [ 3H]5-HT binding to 5-HT 1 receptors...

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Veröffentlicht in:	Neuroscience letters 1996-05, Vol.209 (3), p.153-156
Hauptverfasser:	Hori, Takafumi, Suzuki, Toshihito, Baba, Atsuomi, Abe, Shuzo, Yamamoto, Toshifumi, Moroji, Takashi, Shiraishi, Hiroyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Phenyl-4-(1-piperidinyl)cyclohexanol (4-PPC) Animals Biological and medical sciences Brain - drug effects Brain - metabolism Ketanserin - metabolism Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Paroxetine - metabolism Pharmacology. Drug treatments Phencyclidine (PCP) Phencyclidine - pharmacokinetics Phencyclidine - pharmacology Rat brain Rats Rats, Wistar Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Serotonin - metabolism Serotonin uptake Serotonin Uptake Inhibitors - pharmacology Serotoninergic system
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