S-Methyl-N,N-Diethylthiocarbamate Sulfoxide and S-Methyl-N,N-Diethylthiocarbamate Sulfone, Two Candidates for the Active Metabolite of Disulfiram

The mechanism of action of disulfiram involves inhibition of hepatic aldehyde dehydrogenase (ALDH). Although disulfiram inhibits ALDH in vitro, it is believed that the drug is too short‐lived in vivo to inhibit the enzyme directly. The ultimate inhibitor is thought to be a metabolite of disulfiram....

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