Structural interactions between NOS-positive neurons and blood vessels in the hippocampus
The anatomical relationship between nitric oxide synthase (NOS)-positive neurons and blood vessels was examined in the hippocampus of the rat. NADPH-diaphorase histochemistry was used to identify NOS-positive neurons by light-microscopy. A close association of somatic, dendritic and axonal processes...
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| Veröffentlicht in: | Neuroreport 1996-03, Vol.7 (4), p.966-966 |
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| container_title | Neuroreport |
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| creator | Schottler, Frank Collins, Jennifer L Fergus, Andrea Okonkwo, David Kassell, Neal F Lee, Kevin S |
| description | The anatomical relationship between nitric oxide synthase (NOS)-positive neurons and blood vessels was examined in the hippocampus of the rat. NADPH-diaphorase histochemistry was used to identify NOS-positive neurons by light-microscopy. A close association of somatic, dendritic and axonal processes of NOS-positive neurons with cerebral blood vessels was observed. These findings suggest the possibility of neurovascular signaling by local NOS-containing neurons, through direct vascular innervation by terminals generating nitric oxide, and paracrine signaling from closely apposed somatic and dendritic neuronal elements. |
| doi_str_mv | 10.1097/00001756-199603220-00028 |
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NADPH-diaphorase histochemistry was used to identify NOS-positive neurons by light-microscopy. A close association of somatic, dendritic and axonal processes of NOS-positive neurons with cerebral blood vessels was observed. These findings suggest the possibility of neurovascular signaling by local NOS-containing neurons, through direct vascular innervation by terminals generating nitric oxide, and paracrine signaling from closely apposed somatic and dendritic neuronal elements.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199603220-00028</identifier><identifier>PMID: 8724684</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Anatomy ; Animals ; Biological and medical sciences ; Central nervous system ; Fundamental and applied biological sciences. 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NADPH-diaphorase histochemistry was used to identify NOS-positive neurons by light-microscopy. A close association of somatic, dendritic and axonal processes of NOS-positive neurons with cerebral blood vessels was observed. These findings suggest the possibility of neurovascular signaling by local NOS-containing neurons, through direct vascular innervation by terminals generating nitric oxide, and paracrine signaling from closely apposed somatic and dendritic neuronal elements.</description><subject>Anatomy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - blood supply</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - enzymology</subject><subject>Neurons - enzymology</subject><subject>Nitric Oxide Synthase - analysis</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq0KBFvgJ1TyoeKW1nb8eawQ_ZBQOcABTpbjTLRpvXGwHVb99zXsdm-ovljy-4xH8wxCmJJPlBj1mdRDlZANNUaSljHS1Bem36EV5apthNAPR2hFjDANN1Kcovc5_6qIIVSfoBOtGJear9DjXUmLL0tyAY9TgeR8GeOUcQdlCzDhn7d3zRzzWMZnwBMs6SV0U4-7EGOPnyFnCLnW4rIGvB7nOXq3mZd8jo4HFzJc7O8zdP_1-v7qe3Nz--3H1ZebxnMqdCMH2spOGT_0ZHCOdlI4ppjXREgDfes1494BUC3c4Lnsu7bOzbU0lAnn2zN0uft2TvFpgVzsZsweQnATxCVbpRmTVdZ_QSqEIbVZBfUO9CnmnGCwcxo3Lv2xlNgX-_affXuwb1_t19IP-x5Lt4H-ULjXXfOP-9xl78KQ3OTHfMBaooyipmJ8h21jqCvJv8OyhWTX4EJZ27d23_4FDx2dMg</recordid><startdate>19960322</startdate><enddate>19960322</enddate><creator>Schottler, Frank</creator><creator>Collins, Jennifer L</creator><creator>Fergus, Andrea</creator><creator>Okonkwo, David</creator><creator>Kassell, Neal F</creator><creator>Lee, Kevin S</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19960322</creationdate><title>Structural interactions between NOS-positive neurons and blood vessels in the hippocampus</title><author>Schottler, Frank ; Collins, Jennifer L ; Fergus, Andrea ; Okonkwo, David ; Kassell, Neal F ; Lee, Kevin S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4158-6f136b79cfd0faa1b65a272c80569ed3c824caee185afc46db37564869125ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Anatomy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Fundamental and applied biological sciences. 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| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 1996-03, Vol.7 (4), p.966-966 |
| issn | 0959-4965 1473-558X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Anatomy Animals Biological and medical sciences Central nervous system Fundamental and applied biological sciences. Psychology Hippocampus - blood supply Hippocampus - cytology Hippocampus - enzymology Neurons - enzymology Nitric Oxide Synthase - analysis Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs |
| title | Structural interactions between NOS-positive neurons and blood vessels in the hippocampus |
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