The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

Both the interleukin-2 receptor-alpha (Tac, p55, IL-2Rα) gene and the long terminal repeat (LTR) of type 1 HIV are activated by various T cell mitogens. We now demonstrate that an inducible 86 kd nuclear protein termed HIVEN86A specifically binds to both the enhancer element of the HIV-1 LTR and a c...

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Veröffentlicht in:	Cell 1988-06, Vol.53 (5), p.827-836
Hauptverfasser:	Böhnlein, Ernst, Lowenthal, John W., Siekevitz, Miriam, Ballard, Dean W., Franza, B.Robert, Greene, Warner C.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Base Sequence Biological and medical sciences Cell Line DNA Restriction Enzymes Enhancer Elements, Genetic Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation - drug effects Genes Genes, Fungal Genes, Regulator HIV - genetics Interleukin-2 - metabolism Mitogens - pharmacology Molecular and cellular biology Molecular genetics Molecular Sequence Data Nuclear Proteins - physiology Promoter Regions, Genetic Receptors, Immunologic - genetics Receptors, Interleukin-2 Sequence Homology, Nucleic Acid
Online-Zugang:	Volltext
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