β-Amyloid Accumulation Correlates with Cognitive Dysfunction in the Aged Canine

It is well known that β-amyloid accumulates abnormally in Alzheimer's disease; however, β-amyloid's relationship to cognitive dysfunction has not been clearly established and is often confounded by the presence of neurofibrillary tangles. We used canines to investigate the relationship bet...

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Veröffentlicht in:	Neurobiology of learning and memory 1996-07, Vol.66 (1), p.11-23
Hauptverfasser:	Cummings, Brian J., Head, Elizabeth, Afagh, Arman J., Milgram, Norton W., Cotman, Carl W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Animals Appetitive Behavior - physiology Biological and medical sciences Brain - pathology Cognition Disorders - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Discrimination Learning - physiology Disease Models, Animal Dogs Medical sciences Mental Recall - physiology Neurofibrillary Tangles - pathology Neurology Neurons - pathology Orientation - physiology Retention (Psychology) - physiology
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