Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom : a systematic analysis of predisposing mutations and allelic variation in the PRNP gene

Creutzfeldt-Jakob disease (CJD) is a transmissible neurodegenerative disorder characterized by the accumulation of aggregates of a cellular protein, PrP, in the brain. In both human and animals, genetic alterations to the gene encoding PrP (PRNP in human) modulate susceptibility to CJD. The recent e...

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Veröffentlicht in:	Human genetics 1996-09, Vol.98 (3), p.259-264
Hauptverfasser:	WINDL, O, DEMPSTER, M, PALMER, M. S, COLLINGE, J, ESTIBEIRO, J. P, LATHE, R, DE SILVA, R, ESMONDE, T, WILL, R, SPRINGBETT, A, CAMPBELL, T. A, SIDLE, K. C. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence Biological and medical sciences Creutzfeldt-Jakob Syndrome - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Primers Genetic Predisposition to Disease Genetic Variation Homozygote Humans Medical sciences Molecular Sequence Data Mutation Neurology Prions - genetics United Kingdom
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