Coordinated regulation in human T cells of nucleotide-hydrolyzing ecto- enzymatic activities, including CD38 and PC-1. Possible role in the recycling of nicotinamide adenine dinucleotide metabolites

The human leukocyte surface Ag CD38 was recently identified as a nicotinamide adenine dinucleotide (NAD)(+)-glycohydrolase ecto-enzyme, degrading NAD into nicotinamide and ADP-ribose. We show here that expression of CD38 is increased in the Jurkat T cell line after treatment with agents that augment...

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Veröffentlicht in:	The Journal of immunology (1950) 1996-08, Vol.157 (4), p.1381-1388
Hauptverfasser:	Deterre, P, Gelman, L, Gary-Gouy, H, Arrieumerlou, C, Berthelier, V, Tixier, JM, Ktorza, S, Goding, J, Schmitt, C, Bismuth, G
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase ADP-ribosyl Cyclase 1 Antigens, CD Antigens, Differentiation - metabolism Azaserine - pharmacology Base Sequence Humans Leukemia-Lymphoma, Adult T-Cell - pathology Membrane Glycoproteins - metabolism Molecular Sequence Data N-Glycosyl Hydrolases - metabolism NAD - metabolism NAD+ Nucleosidase - metabolism Neoplasm Proteins - metabolism Nucleotides - metabolism Phosphoric Diester Hydrolases Pyrophosphatases RNA, Messenger - metabolism T-Lymphocyte Subsets - enzymology Tumor Cells, Cultured
Online-Zugang:	Volltext
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