Cell death induced by cytopathic bovine viral diarrhoea virus is mediated by apoptosis
Institute for Animal Health, Compton Laboratory, Compton, Newbury RG20 7NN, UK Cells infected with two closely related isolates of bovine viral diarrhoea virus (BVDV), one cytopathic (CP) and one non-cytopathic (NCP), were examined for signs of apoptosis. The results from labelling DNA using termina...
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| Veröffentlicht in: | Journal of general virology 1996-08, Vol.77 (8), p.1677-1681 |
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| container_title | Journal of general virology |
| container_volume | 77 |
| creator | Zhang, G Aldridge, S Clarke, M. C McCauley, J. W |
| description | Institute for Animal Health, Compton Laboratory, Compton, Newbury RG20 7NN, UK
Cells infected with two closely related isolates of bovine viral diarrhoea virus (BVDV), one cytopathic (CP) and one non-cytopathic (NCP), were examined for signs of apoptosis. The results from labelling DNA using terminal transferase and biotinylated dUTP and by observing oligonucleosomal-sized DNA fragmentation indicated that the CP strain of BVDV induced apoptosis in cell culture but the NCP strain did not. Induction of apoptosis correlated with infected cells undergoing apoptosis rather than interactions between infected and uninfected cells and the induction of apoptosis by CP BVDV was a dominant trait in cells co-infected with both types of virus.
Received 18 December 1995;
accepted 1 April 1996. |
| doi_str_mv | 10.1099/0022-1317-77-8-1677 |
| format | Article |
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Cells infected with two closely related isolates of bovine viral diarrhoea virus (BVDV), one cytopathic (CP) and one non-cytopathic (NCP), were examined for signs of apoptosis. The results from labelling DNA using terminal transferase and biotinylated dUTP and by observing oligonucleosomal-sized DNA fragmentation indicated that the CP strain of BVDV induced apoptosis in cell culture but the NCP strain did not. Induction of apoptosis correlated with infected cells undergoing apoptosis rather than interactions between infected and uninfected cells and the induction of apoptosis by CP BVDV was a dominant trait in cells co-infected with both types of virus.
Received 18 December 1995;
accepted 1 April 1996.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-77-8-1677</identifier><identifier>PMID: 8760414</identifier><language>eng</language><publisher>England: Soc General Microbiol</publisher><subject>Animals ; Apoptosis ; Cattle ; Cell Line ; Cytopathogenic Effect, Viral ; Diarrhea Viruses, Bovine Viral - pathogenicity ; DNA Damage ; Fluorescent Antibody Technique, Indirect</subject><ispartof>Journal of general virology, 1996-08, Vol.77 (8), p.1677-1681</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-1096f4f4af679351da2ce13bfc088b64accb9ed906a64e5f9afe04cf1f47654b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3744,3745,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8760414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, G</creatorcontrib><creatorcontrib>Aldridge, S</creatorcontrib><creatorcontrib>Clarke, M. C</creatorcontrib><creatorcontrib>McCauley, J. W</creatorcontrib><title>Cell death induced by cytopathic bovine viral diarrhoea virus is mediated by apoptosis</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>Institute for Animal Health, Compton Laboratory, Compton, Newbury RG20 7NN, UK
Cells infected with two closely related isolates of bovine viral diarrhoea virus (BVDV), one cytopathic (CP) and one non-cytopathic (NCP), were examined for signs of apoptosis. The results from labelling DNA using terminal transferase and biotinylated dUTP and by observing oligonucleosomal-sized DNA fragmentation indicated that the CP strain of BVDV induced apoptosis in cell culture but the NCP strain did not. Induction of apoptosis correlated with infected cells undergoing apoptosis rather than interactions between infected and uninfected cells and the induction of apoptosis by CP BVDV was a dominant trait in cells co-infected with both types of virus.
Received 18 December 1995;
accepted 1 April 1996.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Cattle</subject><subject>Cell Line</subject><subject>Cytopathogenic Effect, Viral</subject><subject>Diarrhea Viruses, Bovine Viral - pathogenicity</subject><subject>DNA Damage</subject><subject>Fluorescent Antibody Technique, Indirect</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMo4zj6C0TIStxUkzaPdimDLxhwo25DkibTyLSpSavMvzdlhnHpKuSec-7lfABcYnSLUVXdIZTnGS4wzzjPygwzzo_AHBNGszzpx2B-cJyCsxg_EcKEUD4Ds5IzRDCZg4-l2WxgbeTQQNfVozY1VFuot4Pv08xpqPy36wz8dkEmo5MhNN7I6T9G6CJsTRoOu5jsfT_46OI5OLFyE83F_l2A98eHt-Vztnp9elnerzJNUDVkqQazxBJpGa8KimuZa4MLZTUqS8WI1FpVpq4Qk4wYaitpDSLaYks4o0QVC3C929sH_zWaOIjWRZ0qyc74MQpe5nnqzP41YspoUVCSjMXOqIOPMRgr-uBaGbYCIzFhFxNUMUEVnItSTNhT6mq_flQJyCGz55z0m53euHXz44IRa9O1Lt1QzovE8m_VL3NRjJc</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>Zhang, G</creator><creator>Aldridge, S</creator><creator>Clarke, M. C</creator><creator>McCauley, J. W</creator><general>Soc General Microbiol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19960801</creationdate><title>Cell death induced by cytopathic bovine viral diarrhoea virus is mediated by apoptosis</title><author>Zhang, G ; Aldridge, S ; Clarke, M. C ; McCauley, J. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-1096f4f4af679351da2ce13bfc088b64accb9ed906a64e5f9afe04cf1f47654b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Cattle</topic><topic>Cell Line</topic><topic>Cytopathogenic Effect, Viral</topic><topic>Diarrhea Viruses, Bovine Viral - pathogenicity</topic><topic>DNA Damage</topic><topic>Fluorescent Antibody Technique, Indirect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, G</creatorcontrib><creatorcontrib>Aldridge, S</creatorcontrib><creatorcontrib>Clarke, M. C</creatorcontrib><creatorcontrib>McCauley, J. W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, G</au><au>Aldridge, S</au><au>Clarke, M. C</au><au>McCauley, J. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell death induced by cytopathic bovine viral diarrhoea virus is mediated by apoptosis</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>77</volume><issue>8</issue><spage>1677</spage><epage>1681</epage><pages>1677-1681</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>Institute for Animal Health, Compton Laboratory, Compton, Newbury RG20 7NN, UK
Cells infected with two closely related isolates of bovine viral diarrhoea virus (BVDV), one cytopathic (CP) and one non-cytopathic (NCP), were examined for signs of apoptosis. The results from labelling DNA using terminal transferase and biotinylated dUTP and by observing oligonucleosomal-sized DNA fragmentation indicated that the CP strain of BVDV induced apoptosis in cell culture but the NCP strain did not. Induction of apoptosis correlated with infected cells undergoing apoptosis rather than interactions between infected and uninfected cells and the induction of apoptosis by CP BVDV was a dominant trait in cells co-infected with both types of virus.
Received 18 December 1995;
accepted 1 April 1996.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>8760414</pmid><doi>10.1099/0022-1317-77-8-1677</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of general virology, 1996-08, Vol.77 (8), p.1677-1681 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_78221446 |
| source | MEDLINE; Microbiology Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Apoptosis Cattle Cell Line Cytopathogenic Effect, Viral Diarrhea Viruses, Bovine Viral - pathogenicity DNA Damage Fluorescent Antibody Technique, Indirect |
| title | Cell death induced by cytopathic bovine viral diarrhoea virus is mediated by apoptosis |
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