Stimulation of platelet glycoprotein IIb-IIIa (α IIbβ 3-integrin) functional activity by a monoclonal antibody to the N-terminal region of glycoprotein IIIa

Platelet glycoprotein (GP) IIb-IIIa complex (α IIbβ 3-integrin) changes its conformation upon platelet activation that results in binding of RGD-containing ligands and expression of ligand-induced binding site (LIBS) neoepitopes. Anti-GIIb-IIIa monoclonal antibody (monAB) CRC54 bound to ≤10% of GPII...

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Veröffentlicht in:	FEBS letters 1996-08, Vol.391 (1), p.84-88
Hauptverfasser:	Mazurov, Alexey V., Khaspekova, Svetlana G., Byzova, Tatjana V., Tikhomirov, Oleg Yu, Berndt, Michael C., Steiner, Beat, Kouns, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Blood Platelets - drug effects Blood Platelets - physiology CD36 Antigens - immunology CD36 Antigens - physiology Conformation Epitopes - analysis Fibrinogen Fibrinogen - pharmacology glycoprotein Glycoprotein IIb-IIIa Humans Immunoglobulin Fab Fragments - pharmacology In Vitro Techniques Integrin Kinetics LIBS ligand-induced binding site monAB monoclonal antibody Oligopeptides - metabolism Oligopeptides - pharmacology PBS phosphate-buffered saline Platelet Adhesiveness - drug effects Platelet Aggregation - drug effects Platelet Glycoprotein GPIIb-IIIa Complex - immunology Platelet Glycoprotein GPIIb-IIIa Complex - physiology platelet-rich plasma Platelets Protein Conformation PRP
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