Cytotoxicity of ketoconazole in malignant cell lines
The cytotoxic effects of ketoconazole, an antifungal agent known to have some activity against human prostate cancer, adrenal cancer, and male metastatic breast cancer, were evaluated using colony-growth and clonogenic assays in eight malignant cell lines. The cytotoxicity of ketoconazole showed a d...
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| Veröffentlicht in: | Cancer chemotherapy and pharmacology 1988-06, Vol.21 (4), p.319-322 |
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| container_end_page | 322 |
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| container_title | Cancer chemotherapy and pharmacology |
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| creator | ROCHLITZ, C. F DAMON, L. E RUSSI, B. M CADMAN, E. C |
| description | The cytotoxic effects of ketoconazole, an antifungal agent known to have some activity against human prostate cancer, adrenal cancer, and male metastatic breast cancer, were evaluated using colony-growth and clonogenic assays in eight malignant cell lines. The cytotoxicity of ketoconazole showed a dose- and time-dependent pattern, with the following concentrations inhibiting 90% of the growing colonies (IC90): MCF 7 (human breast cancer) 7.25 micrograms/ml, T 47 D (human breast cancer) 9.0 micrograms/ml, MiaPaCa (human pancreatic carcinoma) 10.0 micrograms/ml, COLO 357 (human pancreatic carcinoma), 9.5 micrograms/ml, HCT 8 (human colonic adenocarcinoma) 27.1 micrograms/ml, DU 145 (human prostatic cancer) 40.0 micrograms/ml, AR 42 J (rat pancreatic carcinoma) 9.0 micrograms/ml, and L1210 (murine leukemia) 8.6 micrograms/ml. Since a concentration of 10 micrograms/ml can be achieved in humans, the use of ketoconazole in human malignancies might be worthy of clinical evaluation. |
| doi_str_mv | 10.1007/BF00264198 |
| format | Article |
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E</creatorcontrib><creatorcontrib>RUSSI, B. M</creatorcontrib><creatorcontrib>CADMAN, E. C</creatorcontrib><title>Cytotoxicity of ketoconazole in malignant cell lines</title><title>Cancer chemotherapy and pharmacology</title><addtitle>Cancer Chemother Pharmacol</addtitle><description>The cytotoxic effects of ketoconazole, an antifungal agent known to have some activity against human prostate cancer, adrenal cancer, and male metastatic breast cancer, were evaluated using colony-growth and clonogenic assays in eight malignant cell lines. The cytotoxicity of ketoconazole showed a dose- and time-dependent pattern, with the following concentrations inhibiting 90% of the growing colonies (IC90): MCF 7 (human breast cancer) 7.25 micrograms/ml, T 47 D (human breast cancer) 9.0 micrograms/ml, MiaPaCa (human pancreatic carcinoma) 10.0 micrograms/ml, COLO 357 (human pancreatic carcinoma), 9.5 micrograms/ml, HCT 8 (human colonic adenocarcinoma) 27.1 micrograms/ml, DU 145 (human prostatic cancer) 40.0 micrograms/ml, AR 42 J (rat pancreatic carcinoma) 9.0 micrograms/ml, and L1210 (murine leukemia) 8.6 micrograms/ml. Since a concentration of 10 micrograms/ml can be achieved in humans, the use of ketoconazole in human malignancies might be worthy of clinical evaluation.</description><subject>Animals</subject><subject>Antineoplastic Agents</subject><subject>Biological and medical sciences</subject><subject>Cell Line - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General aspects</subject><subject>Humans</subject><subject>Ketoconazole - pharmacology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neoplasms - pathology</subject><subject>Pharmacology. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxicity of ketoconazole in malignant cell lines</atitle><jtitle>Cancer chemotherapy and pharmacology</jtitle><addtitle>Cancer Chemother Pharmacol</addtitle><date>1988-06</date><risdate>1988</risdate><volume>21</volume><issue>4</issue><spage>319</spage><epage>322</epage><pages>319-322</pages><issn>0344-5704</issn><eissn>1432-0843</eissn><coden>CCPHDZ</coden><abstract>The cytotoxic effects of ketoconazole, an antifungal agent known to have some activity against human prostate cancer, adrenal cancer, and male metastatic breast cancer, were evaluated using colony-growth and clonogenic assays in eight malignant cell lines. The cytotoxicity of ketoconazole showed a dose- and time-dependent pattern, with the following concentrations inhibiting 90% of the growing colonies (IC90): MCF 7 (human breast cancer) 7.25 micrograms/ml, T 47 D (human breast cancer) 9.0 micrograms/ml, MiaPaCa (human pancreatic carcinoma) 10.0 micrograms/ml, COLO 357 (human pancreatic carcinoma), 9.5 micrograms/ml, HCT 8 (human colonic adenocarcinoma) 27.1 micrograms/ml, DU 145 (human prostatic cancer) 40.0 micrograms/ml, AR 42 J (rat pancreatic carcinoma) 9.0 micrograms/ml, and L1210 (murine leukemia) 8.6 micrograms/ml. Since a concentration of 10 micrograms/ml can be achieved in humans, the use of ketoconazole in human malignancies might be worthy of clinical evaluation.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>3370740</pmid><doi>10.1007/BF00264198</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Antineoplastic Agents Biological and medical sciences Cell Line - drug effects Cell Survival - drug effects Drug Screening Assays, Antitumor General aspects Humans Ketoconazole - pharmacology Medical sciences Mice Neoplasms - pathology Pharmacology. Drug treatments Rats Tumor Cells, Cultured - drug effects |
| title | Cytotoxicity of ketoconazole in malignant cell lines |
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