Vasopressin levels in the cerebrospinal fluid of rats with lesions of the paraventricular and suprachiasmatic nuclei
The circadian rhythm and dehydration-induced response of vasopressin (AVP) levels in rat cerebrospinal fluid (CSF) were studied after lesions had been made in the paraventricular (PVN) and suprachiasmatic (SCN) nuclei. The rhythmic fluctuation of AVP levels in CSF was abolished after SCN lesions, wh...
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| Veröffentlicht in: | Neuroscience letters 1988-03, Vol.86 (2), p.184-188 |
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| creator | Jolkkonen, J. Tuomisto, L. van Wimersma Greidanus, Tj.B. Riekkinen, P.J. |
| description | The circadian rhythm and dehydration-induced response of vasopressin (AVP) levels in rat cerebrospinal fluid (CSF) were studied after lesions had been made in the paraventricular (PVN) and suprachiasmatic (SCN) nuclei. The rhythmic fluctuation of AVP levels in CSF was abolished after SCN lesions, whereas lesions of the PVN had no effect. Dehydration seems to increase AVP levels in CSF of both sham-operated and lesioned animals. These data further suggest that the circadian rhythm of AVP in CSF is preferentially generated by SCN. In contrast, several areas of the brain may contribute to the overall AVP levels in CSF, both under normal physiological conditions and under osmotic stress. |
| doi_str_mv | 10.1016/0304-3940(88)90568-X |
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The rhythmic fluctuation of AVP levels in CSF was abolished after SCN lesions, whereas lesions of the PVN had no effect. Dehydration seems to increase AVP levels in CSF of both sham-operated and lesioned animals. These data further suggest that the circadian rhythm of AVP in CSF is preferentially generated by SCN. In contrast, several areas of the brain may contribute to the overall AVP levels in CSF, both under normal physiological conditions and under osmotic stress.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(88)90568-X</identifier><identifier>PMID: 3368120</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Cerebrospinal fluid ; Circadian Rhythm ; Dehydration - cerebrospinal fluid ; Fundamental and applied biological sciences. Psychology ; Male ; Paraventricular Hypothalamic Nucleus - metabolism ; Paraventricular Hypothalamic Nucleus - physiology ; Paraventricular nucleus ; Rat ; Rats ; Rats, Inbred Strains ; Suprachiasmatic nucleus ; Suprachiasmatic Nucleus - metabolism ; Suprachiasmatic Nucleus - physiology ; Vasopressin ; Vasopressins - cerebrospinal fluid ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1988-03, Vol.86 (2), p.184-188</ispartof><rights>1988</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-eeca2a7b7d427ba9139b56f6106f370ccba160a83ced158293598bcfbfbf7cbd3</citedby><cites>FETCH-LOGICAL-c417t-eeca2a7b7d427ba9139b56f6106f370ccba160a83ced158293598bcfbfbf7cbd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(88)90568-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7645697$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3368120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jolkkonen, J.</creatorcontrib><creatorcontrib>Tuomisto, L.</creatorcontrib><creatorcontrib>van Wimersma Greidanus, Tj.B.</creatorcontrib><creatorcontrib>Riekkinen, P.J.</creatorcontrib><title>Vasopressin levels in the cerebrospinal fluid of rats with lesions of the paraventricular and suprachiasmatic nuclei</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The circadian rhythm and dehydration-induced response of vasopressin (AVP) levels in rat cerebrospinal fluid (CSF) were studied after lesions had been made in the paraventricular (PVN) and suprachiasmatic (SCN) nuclei. The rhythmic fluctuation of AVP levels in CSF was abolished after SCN lesions, whereas lesions of the PVN had no effect. Dehydration seems to increase AVP levels in CSF of both sham-operated and lesioned animals. These data further suggest that the circadian rhythm of AVP in CSF is preferentially generated by SCN. In contrast, several areas of the brain may contribute to the overall AVP levels in CSF, both under normal physiological conditions and under osmotic stress.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Cerebrospinal fluid</subject><subject>Circadian Rhythm</subject><subject>Dehydration - cerebrospinal fluid</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Paraventricular Hypothalamic Nucleus - metabolism</subject><subject>Paraventricular Hypothalamic Nucleus - physiology</subject><subject>Paraventricular nucleus</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Suprachiasmatic nucleus</subject><subject>Suprachiasmatic Nucleus - metabolism</subject><subject>Suprachiasmatic Nucleus - physiology</subject><subject>Vasopressin</subject><subject>Vasopressins - cerebrospinal fluid</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2r1TAQhoso1-PVf6CQhYguqkmT5mMjyMUvuOBG5e7CNJ1yIjltzbRH_PemnsNZKlkkzDzzMnnfqnoq-GvBhX7DJVe1dIq_tPaV46229d29aiesaWrjTHO_2l2Qh9Ujoh-c81a06qq6klJb0fBdtXwHmuaMRHFkCY-YiJXXskcWMGOXJ5rjCIkNaY09mwaWYSH2Ky77glOcRtqKGz9DhiOOS45hTZAZjD2jdc4Q9hHoAEsMbFxDwvi4ejBAInxyvq-rbx_ef735VN9--fj55t1tHZQwS40YoAHTmV41pgMnpOtaPWjB9SAND6EDoTlYGbAXrW2cbJ3twtCVY0LXy-vqxUl3ztPPFWnxh0gBU4IRp5W8sY1wWsr_gkI5rpSwBVQnMBRjKOPg5xwPkH97wf2Wit8s95vl3lr_NxV_V8aenfXX7oD9ZegcQ-k_P_eBAqQhwxgiXTCjVaudKdjbE1ZSwmPE7ClEHMv3Y8aw-H6K_97jD_nQq-o</recordid><startdate>19880331</startdate><enddate>19880331</enddate><creator>Jolkkonen, J.</creator><creator>Tuomisto, L.</creator><creator>van Wimersma Greidanus, Tj.B.</creator><creator>Riekkinen, P.J.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19880331</creationdate><title>Vasopressin levels in the cerebrospinal fluid of rats with lesions of the paraventricular and suprachiasmatic nuclei</title><author>Jolkkonen, J. ; Tuomisto, L. ; van Wimersma Greidanus, Tj.B. ; Riekkinen, P.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-eeca2a7b7d427ba9139b56f6106f370ccba160a83ced158293598bcfbfbf7cbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Cerebrospinal fluid</topic><topic>Circadian Rhythm</topic><topic>Dehydration - cerebrospinal fluid</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Paraventricular Hypothalamic Nucleus - metabolism</topic><topic>Paraventricular Hypothalamic Nucleus - physiology</topic><topic>Paraventricular nucleus</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Suprachiasmatic nucleus</topic><topic>Suprachiasmatic Nucleus - metabolism</topic><topic>Suprachiasmatic Nucleus - physiology</topic><topic>Vasopressin</topic><topic>Vasopressins - cerebrospinal fluid</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jolkkonen, J.</creatorcontrib><creatorcontrib>Tuomisto, L.</creatorcontrib><creatorcontrib>van Wimersma Greidanus, Tj.B.</creatorcontrib><creatorcontrib>Riekkinen, P.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jolkkonen, J.</au><au>Tuomisto, L.</au><au>van Wimersma Greidanus, Tj.B.</au><au>Riekkinen, P.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vasopressin levels in the cerebrospinal fluid of rats with lesions of the paraventricular and suprachiasmatic nuclei</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1988-03-31</date><risdate>1988</risdate><volume>86</volume><issue>2</issue><spage>184</spage><epage>188</epage><pages>184-188</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The circadian rhythm and dehydration-induced response of vasopressin (AVP) levels in rat cerebrospinal fluid (CSF) were studied after lesions had been made in the paraventricular (PVN) and suprachiasmatic (SCN) nuclei. The rhythmic fluctuation of AVP levels in CSF was abolished after SCN lesions, whereas lesions of the PVN had no effect. Dehydration seems to increase AVP levels in CSF of both sham-operated and lesioned animals. These data further suggest that the circadian rhythm of AVP in CSF is preferentially generated by SCN. In contrast, several areas of the brain may contribute to the overall AVP levels in CSF, both under normal physiological conditions and under osmotic stress.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>3368120</pmid><doi>10.1016/0304-3940(88)90568-X</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1988-03, Vol.86 (2), p.184-188 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrospinal fluid Circadian Rhythm Dehydration - cerebrospinal fluid Fundamental and applied biological sciences. Psychology Male Paraventricular Hypothalamic Nucleus - metabolism Paraventricular Hypothalamic Nucleus - physiology Paraventricular nucleus Rat Rats Rats, Inbred Strains Suprachiasmatic nucleus Suprachiasmatic Nucleus - metabolism Suprachiasmatic Nucleus - physiology Vasopressin Vasopressins - cerebrospinal fluid Vertebrates: nervous system and sense organs |
| title | Vasopressin levels in the cerebrospinal fluid of rats with lesions of the paraventricular and suprachiasmatic nuclei |
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