The extragenomic action of progesterone on human spermatozoa is influenced by redox regulated changes in tyrosine phosphorylation during capacitation
Capacitation had no effect on the ability of progesterone to elicit a rapid calcium transient in the acrosomal domain of human spermatozoa but had a marked influence on the ability of this steroid to induce a biological response. The development of this responsiveness to progesterone appeared to be...
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| Veröffentlicht in: | Molecular and cellular endocrinology 1996-03, Vol.117 (1), p.83-93 |
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| container_title | Molecular and cellular endocrinology |
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| creator | Aitken, R.John Buckingham, Donna W. Harkiss, Diana Paterson, Margaret Fisher, Helen Irvine, D.Stewart |
| description | Capacitation had no effect on the ability of progesterone to elicit a rapid calcium transient in the acrosomal domain of human spermatozoa but had a marked influence on the ability of this steroid to induce a biological response. The development of this responsiveness to progesterone appeared to be redox regulated in that it was promoted by the stimulation of reactive oxygen species generation and inhibited by the presence of antioxidants, including catalase and membrane permeant thiols. The ability of redox conditions to influence the biological responsiveness of human spermatozoa did not involve changes in the dynamics of the calcium transients induced by progesterone but was causally linked with clear differences in tyrosine phosphorylation. We conclude that the ability of human spermatozoa to respond to the calcium transients induced by progesterone depends on a background of phosphotyrosine expression that can be profoundly influenced by the redox status of the spermatozoa during capacitation. |
| doi_str_mv | 10.1016/0303-7207(95)03733-0 |
| format | Article |
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We conclude that the ability of human spermatozoa to respond to the calcium transients induced by progesterone depends on a background of phosphotyrosine expression that can be profoundly influenced by the redox status of the spermatozoa during capacitation.</description><subject>Extragenomic action</subject><subject>Human spermatozoa</subject><subject>Humans</subject><subject>Male</subject><subject>Oxidation-Reduction</subject><subject>Phosphorylation</subject><subject>Progesterone</subject><subject>Progesterone - physiology</subject><subject>Sperm Capacitation</subject><subject>Spermatozoa - metabolism</subject><subject>Spermatozoa - physiology</subject><subject>Tyrosine - metabolism</subject><subject>Tyrosine phosphorylation</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1r3DAQFaUl3Wz7D1rQqTQHt5JlWdYlEELSBgK9pGchy6NdFVtyJDlk-z_6f6v9IMccNII3b97w3iD0iZJvlND2O2GEVaIm4qvkF4QJxiryBq1oJ-qqI1y8RasXynt0ntIfQojgdXeGzjrBmka0K_TvYQsYnnPUG_BhcgZrk13wOFg8x7CBlCEGD7hA22XSHqcZ4qRz-Bs0dgk7b8cFvIEB9zscYQjPpW6WUecCma32RaOwcN7FkFxRmrchlRd3hbLfNCzR-Q02etbG5QP2Ab2zekzw8fSv0e_bm4frn9X9rx9311f3lWFc5Mq0XUOJaHjdi7qttZFSi44S0w-t7jmvDWmMpFxzy63loudDp4W0skxIyxlboy9H3WL1cSle1eSSgXHUHsKSlOhqKnnLC7E5Ek0xkSJYNUc36bhTlKj9NdQ-arWPWkmuDtcodY0-n_SXfoLhZegUf-lfHvtQTD45iCoZdwjTRTBZDcG9vuA_eRSdIQ</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>Aitken, R.John</creator><creator>Buckingham, Donna W.</creator><creator>Harkiss, Diana</creator><creator>Paterson, Margaret</creator><creator>Fisher, Helen</creator><creator>Irvine, D.Stewart</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960301</creationdate><title>The extragenomic action of progesterone on human spermatozoa is influenced by redox regulated changes in tyrosine phosphorylation during capacitation</title><author>Aitken, R.John ; Buckingham, Donna W. ; Harkiss, Diana ; Paterson, Margaret ; Fisher, Helen ; Irvine, D.Stewart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-c684107452b7262ac99a7810cbd6ab552c04c915a5f5ff57b5d8a79f94529f533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Extragenomic action</topic><topic>Human spermatozoa</topic><topic>Humans</topic><topic>Male</topic><topic>Oxidation-Reduction</topic><topic>Phosphorylation</topic><topic>Progesterone</topic><topic>Progesterone - physiology</topic><topic>Sperm Capacitation</topic><topic>Spermatozoa - metabolism</topic><topic>Spermatozoa - physiology</topic><topic>Tyrosine - metabolism</topic><topic>Tyrosine phosphorylation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aitken, R.John</creatorcontrib><creatorcontrib>Buckingham, Donna W.</creatorcontrib><creatorcontrib>Harkiss, Diana</creatorcontrib><creatorcontrib>Paterson, Margaret</creatorcontrib><creatorcontrib>Fisher, Helen</creatorcontrib><creatorcontrib>Irvine, D.Stewart</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aitken, R.John</au><au>Buckingham, Donna W.</au><au>Harkiss, Diana</au><au>Paterson, Margaret</au><au>Fisher, Helen</au><au>Irvine, D.Stewart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The extragenomic action of progesterone on human spermatozoa is influenced by redox regulated changes in tyrosine phosphorylation during capacitation</atitle><jtitle>Molecular and cellular endocrinology</jtitle><addtitle>Mol Cell Endocrinol</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>117</volume><issue>1</issue><spage>83</spage><epage>93</epage><pages>83-93</pages><issn>0303-7207</issn><eissn>1872-8057</eissn><abstract>Capacitation had no effect on the ability of progesterone to elicit a rapid calcium transient in the acrosomal domain of human spermatozoa but had a marked influence on the ability of this steroid to induce a biological response. 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| fulltext | fulltext |
| identifier | ISSN: 0303-7207 |
| ispartof | Molecular and cellular endocrinology, 1996-03, Vol.117 (1), p.83-93 |
| issn | 0303-7207 1872-8057 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78219565 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Extragenomic action Human spermatozoa Humans Male Oxidation-Reduction Phosphorylation Progesterone Progesterone - physiology Sperm Capacitation Spermatozoa - metabolism Spermatozoa - physiology Tyrosine - metabolism Tyrosine phosphorylation |
| title | The extragenomic action of progesterone on human spermatozoa is influenced by redox regulated changes in tyrosine phosphorylation during capacitation |
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