Expression of the CSF-1 gene in the blast cells of acute myeloblastic leukemia: Association with reduced growth capacity
Myelopoietic growth factors are known to influence the growth in culture of malignant blast cells from human Acute Myeloblastic Leukemia (AML). We have used cDNA clones for the factor CSF‐1 and its receptor fms to study DNA and RNA from the blasts of 25 AML patients. The CSF‐1 gene was always in the...
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| Veröffentlicht in: | Journal of cellular physiology 1988-04, Vol.135 (1), p.133-138 |
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| container_title | Journal of cellular physiology |
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| creator | Wang, Chen Kelleher, C. A. Cheng, G. Y. M. Miyauchi, Jun Wong, Gordon G. Clark, Steven C. Minden, Mark D. McCulloch, Ernest A. |
| description | Myelopoietic growth factors are known to influence the growth in culture of malignant blast cells from human Acute Myeloblastic Leukemia (AML). We have used cDNA clones for the factor CSF‐1 and its receptor fms to study DNA and RNA from the blasts of 25 AML patients. The CSF‐1 gene was always in the germline configuration. CSF‐1 mRNA was found in about half the blast populations. The cells were also studied for their growth properties in culture. A highly significant association was found between CSF‐1 expression and poor growth in suspension culture. Most blast populations expressed fms; the number of fms expression negative samples was too small to permit the detection of any association between fms expression and growth or any interaction between the effects of the expression of the growth factor and its receptor. We propose that CSF‐1 may be an important part of the mechanism determining the balance between self‐renewal and determination in AML blast clones. |
| doi_str_mv | 10.1002/jcp.1041350119 |
| format | Article |
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A. ; Cheng, G. Y. M. ; Miyauchi, Jun ; Wong, Gordon G. ; Clark, Steven C. ; Minden, Mark D. ; McCulloch, Ernest A.</creator><creatorcontrib>Wang, Chen ; Kelleher, C. A. ; Cheng, G. Y. M. ; Miyauchi, Jun ; Wong, Gordon G. ; Clark, Steven C. ; Minden, Mark D. ; McCulloch, Ernest A.</creatorcontrib><description>Myelopoietic growth factors are known to influence the growth in culture of malignant blast cells from human Acute Myeloblastic Leukemia (AML). We have used cDNA clones for the factor CSF‐1 and its receptor fms to study DNA and RNA from the blasts of 25 AML patients. The CSF‐1 gene was always in the germline configuration. CSF‐1 mRNA was found in about half the blast populations. The cells were also studied for their growth properties in culture. A highly significant association was found between CSF‐1 expression and poor growth in suspension culture. Most blast populations expressed fms; the number of fms expression negative samples was too small to permit the detection of any association between fms expression and growth or any interaction between the effects of the expression of the growth factor and its receptor. We propose that CSF‐1 may be an important part of the mechanism determining the balance between self‐renewal and determination in AML blast clones.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.1041350119</identifier><identifier>PMID: 3259234</identifier><identifier>CODEN: JCLLAX</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; Blast Crisis - pathology ; Cell Division ; Cells, Cultured ; Cloning, Molecular ; Colony-Stimulating Factors - genetics ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Genes ; Humans ; Leukemia, Myeloid, Acute - pathology ; Molecular and cellular biology ; Molecular genetics ; Nucleic Acid Hybridization ; RNA, Messenger - analysis ; RNA, Messenger - genetics ; Transcription, Genetic</subject><ispartof>Journal of cellular physiology, 1988-04, Vol.135 (1), p.133-138</ispartof><rights>Copyright © 1988 Wiley‐Liss, Inc.</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4389-5a1119cb9918a99c272251405ad987877db7e24f845852136328ed425d2c10c03</citedby><cites>FETCH-LOGICAL-c4389-5a1119cb9918a99c272251405ad987877db7e24f845852136328ed425d2c10c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.1041350119$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.1041350119$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6971092$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3259234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Chen</creatorcontrib><creatorcontrib>Kelleher, C. A.</creatorcontrib><creatorcontrib>Cheng, G. Y. M.</creatorcontrib><creatorcontrib>Miyauchi, Jun</creatorcontrib><creatorcontrib>Wong, Gordon G.</creatorcontrib><creatorcontrib>Clark, Steven C.</creatorcontrib><creatorcontrib>Minden, Mark D.</creatorcontrib><creatorcontrib>McCulloch, Ernest A.</creatorcontrib><title>Expression of the CSF-1 gene in the blast cells of acute myeloblastic leukemia: Association with reduced growth capacity</title><title>Journal of cellular physiology</title><addtitle>J. Cell. Physiol</addtitle><description>Myelopoietic growth factors are known to influence the growth in culture of malignant blast cells from human Acute Myeloblastic Leukemia (AML). We have used cDNA clones for the factor CSF‐1 and its receptor fms to study DNA and RNA from the blasts of 25 AML patients. The CSF‐1 gene was always in the germline configuration. CSF‐1 mRNA was found in about half the blast populations. The cells were also studied for their growth properties in culture. A highly significant association was found between CSF‐1 expression and poor growth in suspension culture. Most blast populations expressed fms; the number of fms expression negative samples was too small to permit the detection of any association between fms expression and growth or any interaction between the effects of the expression of the growth factor and its receptor. We propose that CSF‐1 may be an important part of the mechanism determining the balance between self‐renewal and determination in AML blast clones.</description><subject>Biological and medical sciences</subject><subject>Blast Crisis - pathology</subject><subject>Cell Division</subject><subject>Cells, Cultured</subject><subject>Cloning, Molecular</subject><subject>Colony-Stimulating Factors - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Nucleic Acid Hybridization</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - genetics</subject><subject>Transcription, Genetic</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhS0EKqGwZYfkBWI3xdeP8ZhdiZoCKg8JEOwsx3OndTuZGewZJfn3OE0UxKorP853jn11CHkJ7AwY429v_ZA3EoRiAOYRmQEzupCl4o_JLANQGCXhKXmW0i1jzBghTsiJ4MpwIWdkc7EZIqYU-o72DR1vkM6_Lwqg19ghDd39zbJ1aaQe2zbtIOenEelqi21_rwRPW5zucBXcO3qeUu-DG3eB6zDe0Ij15LGm17Ff56N3g_Nh3D4nTxrXJnxxWE_Jz8XFj_mH4urr5cf5-VXhpahMoRzksfzSGKicMZ5rzhVIplxtKl1pXS81ctlUUlWKgygFr7CWXNXcA_NMnJI3-9wh9n8mTKNdhbQbxXXYT8nqikNZcvEgCApKw0vI4Nke9LFPKWJjhxhWLm4tMLvrxOZO7L9OsuHVIXlarrA-4ocSsv76oLvkXdtE1_mQjlhpdO6UZ8zssXVocfvAo_bT_Nt_Xyj23pBG3By9Lt7ZUgut7K8vl_Zzad5L_nthpfgL2U-yRw</recordid><startdate>198804</startdate><enddate>198804</enddate><creator>Wang, Chen</creator><creator>Kelleher, C. A.</creator><creator>Cheng, G. Y. M.</creator><creator>Miyauchi, Jun</creator><creator>Wong, Gordon G.</creator><creator>Clark, Steven C.</creator><creator>Minden, Mark D.</creator><creator>McCulloch, Ernest A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>198804</creationdate><title>Expression of the CSF-1 gene in the blast cells of acute myeloblastic leukemia: Association with reduced growth capacity</title><author>Wang, Chen ; Kelleher, C. A. ; Cheng, G. Y. M. ; Miyauchi, Jun ; Wong, Gordon G. ; Clark, Steven C. ; Minden, Mark D. ; McCulloch, Ernest A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4389-5a1119cb9918a99c272251405ad987877db7e24f845852136328ed425d2c10c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Biological and medical sciences</topic><topic>Blast Crisis - pathology</topic><topic>Cell Division</topic><topic>Cells, Cultured</topic><topic>Cloning, Molecular</topic><topic>Colony-Stimulating Factors - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Nucleic Acid Hybridization</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - genetics</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Chen</creatorcontrib><creatorcontrib>Kelleher, C. A.</creatorcontrib><creatorcontrib>Cheng, G. Y. 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A.</au><au>Cheng, G. Y. M.</au><au>Miyauchi, Jun</au><au>Wong, Gordon G.</au><au>Clark, Steven C.</au><au>Minden, Mark D.</au><au>McCulloch, Ernest A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of the CSF-1 gene in the blast cells of acute myeloblastic leukemia: Association with reduced growth capacity</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J. Cell. Physiol</addtitle><date>1988-04</date><risdate>1988</risdate><volume>135</volume><issue>1</issue><spage>133</spage><epage>138</epage><pages>133-138</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><coden>JCLLAX</coden><abstract>Myelopoietic growth factors are known to influence the growth in culture of malignant blast cells from human Acute Myeloblastic Leukemia (AML). We have used cDNA clones for the factor CSF‐1 and its receptor fms to study DNA and RNA from the blasts of 25 AML patients. The CSF‐1 gene was always in the germline configuration. 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| subjects | Biological and medical sciences Blast Crisis - pathology Cell Division Cells, Cultured Cloning, Molecular Colony-Stimulating Factors - genetics Fundamental and applied biological sciences. Psychology Gene expression Genes Humans Leukemia, Myeloid, Acute - pathology Molecular and cellular biology Molecular genetics Nucleic Acid Hybridization RNA, Messenger - analysis RNA, Messenger - genetics Transcription, Genetic |
| title | Expression of the CSF-1 gene in the blast cells of acute myeloblastic leukemia: Association with reduced growth capacity |
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