Hematopoietic growth factors (BPA and Epo) induce the expressions of c- myc and c- fos proto-oncogenes in normal human erythroid progenitors
We investigated serial expressions of eight proto-oncogenes during in-vitro differentiation of normal human burst-forming unit, erythroid (BFU-E), and found that c- myc and c- fos are expressed in progenies of BFU-E. The expressions of the two proto-oncogenes correlated to the replating efficiency a...
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| Veröffentlicht in: | Leukemia research 1988, Vol.12 (3), p.187-194 |
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| container_issue | 3 |
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| container_title | Leukemia research |
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| creator | Umemura, Tsukuru Umene, Kenichi Takahira, Hiroyuki Takeichi, Naohisa Katsuno, Makoto Fukumaki, Yasuyuki Nishimura, Junji Sakaki, Yoshiyuki Ibayashi, Hiroshi |
| description | We investigated serial expressions of eight proto-oncogenes during
in-vitro differentiation of normal human burst-forming unit, erythroid (BFU-E), and found that c-
myc and c-
fos are expressed in progenies of BFU-E. The expressions of the two proto-oncogenes correlated to the replating efficiency and adversely to erythroid differentiation. The absence of hematopoietic growth factors decreased the expressions, but the addition of erythropoietin together with burst promoting activity induced a re-expression of the c-
myc and c-
fos after 2 h of incubation. These observations suggest that the c-
myc and c-
fos proto-oncogenes have a physiological role in the proliferation of erythroid progenitors and that activations of the two proto-oncogenes are early cellular events after the stimulation by hematopoietic growth factors. |
| doi_str_mv | 10.1016/0145-2126(88)90135-X |
| format | Article |
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in-vitro differentiation of normal human burst-forming unit, erythroid (BFU-E), and found that c-
myc and c-
fos are expressed in progenies of BFU-E. The expressions of the two proto-oncogenes correlated to the replating efficiency and adversely to erythroid differentiation. The absence of hematopoietic growth factors decreased the expressions, but the addition of erythropoietin together with burst promoting activity induced a re-expression of the c-
myc and c-
fos after 2 h of incubation. These observations suggest that the c-
myc and c-
fos proto-oncogenes have a physiological role in the proliferation of erythroid progenitors and that activations of the two proto-oncogenes are early cellular events after the stimulation by hematopoietic growth factors.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/0145-2126(88)90135-X</identifier><identifier>PMID: 3285103</identifier><identifier>CODEN: LEREDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>BFU-E ; Biological and medical sciences ; burst promoting activity ; c- fos ; c- myc ; Cell Differentiation ; Cell differentiation, maturation, development, hematopoiesis ; Cell Division ; Cell physiology ; Erythropoiesis ; erythropoietin ; Erythropoietin - pharmacology ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - drug effects ; Growth Substances - pharmacology ; Hematopoietic Cell Growth Factors ; Hematopoietic Stem Cells - physiology ; Humans ; Molecular and cellular biology ; proto-oncogene ; Proto-Oncogenes - drug effects</subject><ispartof>Leukemia research, 1988, Vol.12 (3), p.187-194</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-900cefafd26ec8895a4259e4241dfb7abde9a12f2f1909e23edc592257e9740a3</citedby><cites>FETCH-LOGICAL-c417t-900cefafd26ec8895a4259e4241dfb7abde9a12f2f1909e23edc592257e9740a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/014521268890135X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7093009$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3285103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Umemura, Tsukuru</creatorcontrib><creatorcontrib>Umene, Kenichi</creatorcontrib><creatorcontrib>Takahira, Hiroyuki</creatorcontrib><creatorcontrib>Takeichi, Naohisa</creatorcontrib><creatorcontrib>Katsuno, Makoto</creatorcontrib><creatorcontrib>Fukumaki, Yasuyuki</creatorcontrib><creatorcontrib>Nishimura, Junji</creatorcontrib><creatorcontrib>Sakaki, Yoshiyuki</creatorcontrib><creatorcontrib>Ibayashi, Hiroshi</creatorcontrib><title>Hematopoietic growth factors (BPA and Epo) induce the expressions of c- myc and c- fos proto-oncogenes in normal human erythroid progenitors</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>We investigated serial expressions of eight proto-oncogenes during
in-vitro differentiation of normal human burst-forming unit, erythroid (BFU-E), and found that c-
myc and c-
fos are expressed in progenies of BFU-E. The expressions of the two proto-oncogenes correlated to the replating efficiency and adversely to erythroid differentiation. The absence of hematopoietic growth factors decreased the expressions, but the addition of erythropoietin together with burst promoting activity induced a re-expression of the c-
myc and c-
fos after 2 h of incubation. These observations suggest that the c-
myc and c-
fos proto-oncogenes have a physiological role in the proliferation of erythroid progenitors and that activations of the two proto-oncogenes are early cellular events after the stimulation by hematopoietic growth factors.</description><subject>BFU-E</subject><subject>Biological and medical sciences</subject><subject>burst promoting activity</subject><subject>c- fos</subject><subject>c- myc</subject><subject>Cell Differentiation</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell Division</subject><subject>Cell physiology</subject><subject>Erythropoiesis</subject><subject>erythropoietin</subject><subject>Erythropoietin - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Growth Substances - pharmacology</subject><subject>Hematopoietic Cell Growth Factors</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>proto-oncogene</subject><subject>Proto-Oncogenes - drug effects</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFCEUx4nR1O3qN9CEgzHtYRQY2IFLk9pUa9JED5r0Rlh4dDEzsAKj3e_gh3amu9mjHggk7_d_74UfQq8oeUcJXb0nlIuGUbY6k_JcEdqK5u4JWlDZtY2QrXiKFkfkOTot5QchRCiqTtBJy6SgpF2gPzcwmJq2KUANFt_n9LtusDe2plzw2Yevl9hEh6-36RyH6EYLuG4Aw8M2QykhxYKTx7bBw84-ktPTp4K3OdXUpGjTPUQoUxbHlAfT4804mIgh7-omp-BmckLCPO8FeuZNX-Dl4V6i7x-vv13dNLdfPn2-urxtLKddbRQhFrzxjq3ASqmE4Uwo4IxT59edWTtQhjLPPFVEAWvBWaEYEx2ojhPTLtHbfd9p9s8RStVDKBb63kRIY9GdZJS3kv8XpIJLyng3gXwP2pxKyeD1NofB5J2mRM-29KxCzyq0lPrRlr6bYq8P_cf1AO4YOuiZ6m8OdVOs6X020YZyxDqiWjKdJbrYYzB92q8AWRcbIFpwIYOt2qXw7z3-ArFMshY</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Umemura, Tsukuru</creator><creator>Umene, Kenichi</creator><creator>Takahira, Hiroyuki</creator><creator>Takeichi, Naohisa</creator><creator>Katsuno, Makoto</creator><creator>Fukumaki, Yasuyuki</creator><creator>Nishimura, Junji</creator><creator>Sakaki, Yoshiyuki</creator><creator>Ibayashi, Hiroshi</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Hematopoietic growth factors (BPA and Epo) induce the expressions of c- myc and c- fos proto-oncogenes in normal human erythroid progenitors</title><author>Umemura, Tsukuru ; Umene, Kenichi ; Takahira, Hiroyuki ; Takeichi, Naohisa ; Katsuno, Makoto ; Fukumaki, Yasuyuki ; Nishimura, Junji ; Sakaki, Yoshiyuki ; Ibayashi, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-900cefafd26ec8895a4259e4241dfb7abde9a12f2f1909e23edc592257e9740a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>BFU-E</topic><topic>Biological and medical sciences</topic><topic>burst promoting activity</topic><topic>c- fos</topic><topic>c- myc</topic><topic>Cell Differentiation</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell Division</topic><topic>Cell physiology</topic><topic>Erythropoiesis</topic><topic>erythropoietin</topic><topic>Erythropoietin - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Growth Substances - pharmacology</topic><topic>Hematopoietic Cell Growth Factors</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>proto-oncogene</topic><topic>Proto-Oncogenes - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Umemura, Tsukuru</creatorcontrib><creatorcontrib>Umene, Kenichi</creatorcontrib><creatorcontrib>Takahira, Hiroyuki</creatorcontrib><creatorcontrib>Takeichi, Naohisa</creatorcontrib><creatorcontrib>Katsuno, Makoto</creatorcontrib><creatorcontrib>Fukumaki, Yasuyuki</creatorcontrib><creatorcontrib>Nishimura, Junji</creatorcontrib><creatorcontrib>Sakaki, Yoshiyuki</creatorcontrib><creatorcontrib>Ibayashi, Hiroshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Umemura, Tsukuru</au><au>Umene, Kenichi</au><au>Takahira, Hiroyuki</au><au>Takeichi, Naohisa</au><au>Katsuno, Makoto</au><au>Fukumaki, Yasuyuki</au><au>Nishimura, Junji</au><au>Sakaki, Yoshiyuki</au><au>Ibayashi, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hematopoietic growth factors (BPA and Epo) induce the expressions of c- myc and c- fos proto-oncogenes in normal human erythroid progenitors</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>1988</date><risdate>1988</risdate><volume>12</volume><issue>3</issue><spage>187</spage><epage>194</epage><pages>187-194</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><coden>LEREDD</coden><abstract>We investigated serial expressions of eight proto-oncogenes during
in-vitro differentiation of normal human burst-forming unit, erythroid (BFU-E), and found that c-
myc and c-
fos are expressed in progenies of BFU-E. The expressions of the two proto-oncogenes correlated to the replating efficiency and adversely to erythroid differentiation. The absence of hematopoietic growth factors decreased the expressions, but the addition of erythropoietin together with burst promoting activity induced a re-expression of the c-
myc and c-
fos after 2 h of incubation. These observations suggest that the c-
myc and c-
fos proto-oncogenes have a physiological role in the proliferation of erythroid progenitors and that activations of the two proto-oncogenes are early cellular events after the stimulation by hematopoietic growth factors.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3285103</pmid><doi>10.1016/0145-2126(88)90135-X</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Leukemia research, 1988, Vol.12 (3), p.187-194 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | BFU-E Biological and medical sciences burst promoting activity c- fos c- myc Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell Division Cell physiology Erythropoiesis erythropoietin Erythropoietin - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Growth Substances - pharmacology Hematopoietic Cell Growth Factors Hematopoietic Stem Cells - physiology Humans Molecular and cellular biology proto-oncogene Proto-Oncogenes - drug effects |
| title | Hematopoietic growth factors (BPA and Epo) induce the expressions of c- myc and c- fos proto-oncogenes in normal human erythroid progenitors |
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