Recognition of DNA by designed ligands at subnanomolar concentrations

SMALL molecules that specifically bind with high affinity to any predetermined DNA sequence in the human genome would be useful tools in molecular biology and potentially in human medicine. Simple rules have been developed to control rationally the sequence specificity of minor-groove-binding polyam...

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Veröffentlicht in:	Nature (London) 1996-08, Vol.382 (6591), p.559-561
Hauptverfasser:	Trauger, John W., Baird, Eldon E., Dervan, Peter B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - chemistry Amides - metabolism Amino acids Base Sequence Biochemistry Biopolymers Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA Footprinting Drug Design Humanities and Social Sciences Imidazoles - chemistry letter Ligands Molecular biology Molecular Sequence Data Molecular Structure multidisciplinary Polyamides Pyrroles - chemistry Science Science (multidisciplinary)
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