Monoclonal IgG as antigens: reduction is an early intracellular event of their processing by antigen-presenting cells

Murine mAb injected into patients behave as exogenous antigens and trigger a specific immune response characterized mainly by CD4+ T lymphocytes. They are recognized by T cells under a processed form and in a MHC class II-restricted fashion. IgG degradation which occurs in antigen-presenting cells (...

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Veröffentlicht in:International immunology 1996-02, Vol.8 (2), p.211-219
Hauptverfasser: Santoro, Lyse, Reboul, Angeline, Kerblat, Isabelle, Drouet, Christian, Colomb, Maurice G.
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Sprache:eng
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