Cdc25 cell-cycle phosphatase as a target of c-myc
The product of the proto-oncogene c- myc , in partnership with Max, forms a transcription factor that can promote either oncogenic transformation or apoptosis. The Myc/Max heterodimer binds to elements in the cdc25A gene and activates transcription. Like myc , cdc25A , itself a proto-oncogene, can i...
Gespeichert in:
| Veröffentlicht in: | Nature (London) 1996-08, Vol.382 (6591), p.511-517 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 517 |
|---|---|
| container_issue | 6591 |
| container_start_page | 511 |
| container_title | Nature (London) |
| container_volume | 382 |
| creator | Galaktionov, Konstantin Chen, Xiaocun Beach, David |
| description | The product of the proto-oncogene c-
myc
, in partnership with Max, forms a transcription factor that can promote either oncogenic transformation or apoptosis. The Myc/Max heterodimer binds to elements in the
cdc25A
gene and activates transcription. Like
myc
,
cdc25A
, itself a proto-oncogene, can induce apoptosis in cells depleted of growth factor, and Myc-induced apoptosis also requires
cdc25A
. These findings indicate that
cdc25A
is a physiologically relevant transcriptional target of c-
myc
. |
| doi_str_mv | 10.1038/382511a0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_78208523</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>743114476</sourcerecordid><originalsourceid>FETCH-LOGICAL-p262t-e1b6fdefbb7f84be19acef0938301b8e4b99ea344181a40090efcfead3e9eb9a3</originalsourceid><addsrcrecordid>eNqFkU1Lw0AQhhdRaq2Cf0AIHhQP0ZndTXb3KMUvKHjRc9jdTNpK0sRseui_d0srggc9zeF5eJmZl7FzhFsEoe-E5hmihQM2RqnyVOZaHbIxANcpaJEfs5MQPgAgQyVHbKRVRFyOGU5Lz7PEU12nfuNrSrpFG7qFHWygxIbEJoPt5zQkbZX4tNn4U3ZU2TrQ2X5O2Pvjw9v0OZ29Pr1M72dpx3M-pIQur0qqnFOVlo7QWE8VGKEFoNMknTFkhZSo0UoAA1T5imwpyJAzVkzY1S6369vPNYWhaJZhu6ddUbsOhdIcdMZFFK__FqVAlPEr_0ZilhnkSkXx8pf40a77VTy34CBlLpXKonSxl9auobLo-mVj-02x_23kNzseIlnNqf8JQSi2tRXftYkv5N6Ehw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204464775</pqid></control><display><type>article</type><title>Cdc25 cell-cycle phosphatase as a target of c-myc</title><source>MEDLINE</source><source>Nature Journals Online</source><source>SpringerLink Journals - AutoHoldings</source><creator>Galaktionov, Konstantin ; Chen, Xiaocun ; Beach, David</creator><creatorcontrib>Galaktionov, Konstantin ; Chen, Xiaocun ; Beach, David</creatorcontrib><description>The product of the proto-oncogene c-
myc
, in partnership with Max, forms a transcription factor that can promote either oncogenic transformation or apoptosis. The Myc/Max heterodimer binds to elements in the
cdc25A
gene and activates transcription. Like
myc
,
cdc25A
, itself a proto-oncogene, can induce apoptosis in cells depleted of growth factor, and Myc-induced apoptosis also requires
cdc25A
. These findings indicate that
cdc25A
is a physiologically relevant transcriptional target of c-
myc
.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/382511a0</identifier><identifier>PMID: 8700224</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>3T3 Cells ; Animals ; Apoptosis - genetics ; Binding Sites ; cdc25 Phosphatases ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Cell Line ; Cell Transformation, Neoplastic - genetics ; Cellular biology ; Cloning, Molecular ; DNA ; Gene Expression Regulation ; Genes ; Humanities and Social Sciences ; Humans ; Mice ; Molecular Sequence Data ; multidisciplinary ; Phosphoprotein Phosphatases - genetics ; Phosphoprotein Phosphatases - metabolism ; Protein Binding ; Proto-Oncogene Proteins c-myc - metabolism ; RNA, Messenger - metabolism ; Science ; Science (multidisciplinary) ; Transcription, Genetic</subject><ispartof>Nature (London), 1996-08, Vol.382 (6591), p.511-517</ispartof><rights>Springer Nature Limited 1996</rights><rights>Copyright Macmillan Journals Ltd. Aug 8, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/382511a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/382511a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8700224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galaktionov, Konstantin</creatorcontrib><creatorcontrib>Chen, Xiaocun</creatorcontrib><creatorcontrib>Beach, David</creatorcontrib><title>Cdc25 cell-cycle phosphatase as a target of c-myc</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>The product of the proto-oncogene c-
myc
, in partnership with Max, forms a transcription factor that can promote either oncogenic transformation or apoptosis. The Myc/Max heterodimer binds to elements in the
cdc25A
gene and activates transcription. Like
myc
,
cdc25A
, itself a proto-oncogene, can induce apoptosis in cells depleted of growth factor, and Myc-induced apoptosis also requires
cdc25A
. These findings indicate that
cdc25A
is a physiologically relevant transcriptional target of c-
myc
.</description><subject>3T3 Cells</subject><subject>Animals</subject><subject>Apoptosis - genetics</subject><subject>Binding Sites</subject><subject>cdc25 Phosphatases</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Line</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cellular biology</subject><subject>Cloning, Molecular</subject><subject>DNA</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Phosphoprotein Phosphatases - genetics</subject><subject>Phosphoprotein Phosphatases - metabolism</subject><subject>Protein Binding</subject><subject>Proto-Oncogene Proteins c-myc - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Transcription, Genetic</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1Lw0AQhhdRaq2Cf0AIHhQP0ZndTXb3KMUvKHjRc9jdTNpK0sRseui_d0srggc9zeF5eJmZl7FzhFsEoe-E5hmihQM2RqnyVOZaHbIxANcpaJEfs5MQPgAgQyVHbKRVRFyOGU5Lz7PEU12nfuNrSrpFG7qFHWygxIbEJoPt5zQkbZX4tNn4U3ZU2TrQ2X5O2Pvjw9v0OZ29Pr1M72dpx3M-pIQur0qqnFOVlo7QWE8VGKEFoNMknTFkhZSo0UoAA1T5imwpyJAzVkzY1S6369vPNYWhaJZhu6ddUbsOhdIcdMZFFK__FqVAlPEr_0ZilhnkSkXx8pf40a77VTy34CBlLpXKonSxl9auobLo-mVj-02x_23kNzseIlnNqf8JQSi2tRXftYkv5N6Ehw</recordid><startdate>19960808</startdate><enddate>19960808</enddate><creator>Galaktionov, Konstantin</creator><creator>Chen, Xiaocun</creator><creator>Beach, David</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>19960808</creationdate><title>Cdc25 cell-cycle phosphatase as a target of c-myc</title><author>Galaktionov, Konstantin ; Chen, Xiaocun ; Beach, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p262t-e1b6fdefbb7f84be19acef0938301b8e4b99ea344181a40090efcfead3e9eb9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>3T3 Cells</topic><topic>Animals</topic><topic>Apoptosis - genetics</topic><topic>Binding Sites</topic><topic>cdc25 Phosphatases</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Line</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cellular biology</topic><topic>Cloning, Molecular</topic><topic>DNA</topic><topic>Gene Expression Regulation</topic><topic>Genes</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>multidisciplinary</topic><topic>Phosphoprotein Phosphatases - genetics</topic><topic>Phosphoprotein Phosphatases - metabolism</topic><topic>Protein Binding</topic><topic>Proto-Oncogene Proteins c-myc - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galaktionov, Konstantin</creatorcontrib><creatorcontrib>Chen, Xiaocun</creatorcontrib><creatorcontrib>Beach, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galaktionov, Konstantin</au><au>Chen, Xiaocun</au><au>Beach, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cdc25 cell-cycle phosphatase as a target of c-myc</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1996-08-08</date><risdate>1996</risdate><volume>382</volume><issue>6591</issue><spage>511</spage><epage>517</epage><pages>511-517</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>The product of the proto-oncogene c-
myc
, in partnership with Max, forms a transcription factor that can promote either oncogenic transformation or apoptosis. The Myc/Max heterodimer binds to elements in the
cdc25A
gene and activates transcription. Like
myc
,
cdc25A
, itself a proto-oncogene, can induce apoptosis in cells depleted of growth factor, and Myc-induced apoptosis also requires
cdc25A
. These findings indicate that
cdc25A
is a physiologically relevant transcriptional target of c-
myc
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8700224</pmid><doi>10.1038/382511a0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1996-08, Vol.382 (6591), p.511-517 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78208523 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 3T3 Cells Animals Apoptosis - genetics Binding Sites cdc25 Phosphatases Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line Cell Transformation, Neoplastic - genetics Cellular biology Cloning, Molecular DNA Gene Expression Regulation Genes Humanities and Social Sciences Humans Mice Molecular Sequence Data multidisciplinary Phosphoprotein Phosphatases - genetics Phosphoprotein Phosphatases - metabolism Protein Binding Proto-Oncogene Proteins c-myc - metabolism RNA, Messenger - metabolism Science Science (multidisciplinary) Transcription, Genetic |
| title | Cdc25 cell-cycle phosphatase as a target of c-myc |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T14%3A46%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cdc25%20cell-cycle%20phosphatase%20as%20a%20target%20of%20c-myc&rft.jtitle=Nature%20(London)&rft.au=Galaktionov,%20Konstantin&rft.date=1996-08-08&rft.volume=382&rft.issue=6591&rft.spage=511&rft.epage=517&rft.pages=511-517&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/382511a0&rft_dat=%3Cproquest_pubme%3E743114476%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204464775&rft_id=info:pmid/8700224&rfr_iscdi=true |