Complete hydatidiform mole with a coexistent embryo
We describe a case of a complete hydatidiform mole with a coexistent embryo. A 19-year-old Hispanic woman presented with an intrauterine pregnancy at 7 weeks gestational age. An ultrasound evaluation at that time showed a gestational sac and fetal heart activity was observed. Four weeks later, subse...
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| Veröffentlicht in: | Human pathology 1996-07, Vol.27 (7), p.731-734 |
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| container_title | Human pathology |
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| creator | Baergen, Rebecca N Kelly, Thomas McGinniss, Matthew J Jones, Oliver W Benirschke, Kurt |
| description | We describe a case of a complete hydatidiform mole with a coexistent embryo. A 19-year-old Hispanic woman presented with an intrauterine pregnancy at 7 weeks gestational age. An ultrasound evaluation at that time showed a gestational sac and fetal heart activity was observed. Four weeks later, subsequent ultrasound study revealed no evidence of an embryo, and a pattern consistent with a hydatidiform mole. Dilation and curettage was subsequently performed that showed a classic hydatidiform mole on histological examination. Chromosome analysis revealed a normal 46,XX karyotype. DNA was extracted from the placental tissue, as well as maternal and paternal blood. Molecular genetic analysis was performed with four variable number of tandem repeats (VNTR) probes and showed the placental tissue to consist of only paternal DNA with two genomic copies of each allele studied. These findings are consistent with the diagnosis of complete hydatidiform mole and its origin from an empty ovum fertilized by a single sperm. This is the first reported case of a living embryo coexistent with a complete hydatidiform mole documented by genetic analysis. |
| doi_str_mv | 10.1016/S0046-8177(96)90406-2 |
| format | Article |
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A 19-year-old Hispanic woman presented with an intrauterine pregnancy at 7 weeks gestational age. An ultrasound evaluation at that time showed a gestational sac and fetal heart activity was observed. Four weeks later, subsequent ultrasound study revealed no evidence of an embryo, and a pattern consistent with a hydatidiform mole. Dilation and curettage was subsequently performed that showed a classic hydatidiform mole on histological examination. Chromosome analysis revealed a normal 46,XX karyotype. DNA was extracted from the placental tissue, as well as maternal and paternal blood. Molecular genetic analysis was performed with four variable number of tandem repeats (VNTR) probes and showed the placental tissue to consist of only paternal DNA with two genomic copies of each allele studied. These findings are consistent with the diagnosis of complete hydatidiform mole and its origin from an empty ovum fertilized by a single sperm. This is the first reported case of a living embryo coexistent with a complete hydatidiform mole documented by genetic analysis.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(96)90406-2</identifier><identifier>PMID: 8698320</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; complete hydatidiform mole ; Diseases of mother, fetus and pregnancy ; DNA - genetics ; DNA - isolation & purification ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Hydatidiform Mole - diagnostic imaging ; Hydatidiform Mole - genetics ; Hydatidiform Mole - pathology ; Karyotyping ; Male ; Medical sciences ; Molecular Probes ; Paternity ; placenta ; Pregnancy ; Pregnancy. Fetus. Placenta ; Ultrasonography, Prenatal ; Uterine Neoplasms - diagnostic imaging ; Uterine Neoplasms - genetics ; Uterine Neoplasms - pathology</subject><ispartof>Human pathology, 1996-07, Vol.27 (7), p.731-734</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-5dd90cf8a045ab00b286a57bd897b1b6ad2d0778e0cc332a8f630c256ad43a8a3</citedby><cites>FETCH-LOGICAL-c389t-5dd90cf8a045ab00b286a57bd897b1b6ad2d0778e0cc332a8f630c256ad43a8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0046-8177(96)90406-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3166503$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8698320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baergen, Rebecca N</creatorcontrib><creatorcontrib>Kelly, Thomas</creatorcontrib><creatorcontrib>McGinniss, Matthew J</creatorcontrib><creatorcontrib>Jones, Oliver W</creatorcontrib><creatorcontrib>Benirschke, Kurt</creatorcontrib><title>Complete hydatidiform mole with a coexistent embryo</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>We describe a case of a complete hydatidiform mole with a coexistent embryo. A 19-year-old Hispanic woman presented with an intrauterine pregnancy at 7 weeks gestational age. An ultrasound evaluation at that time showed a gestational sac and fetal heart activity was observed. Four weeks later, subsequent ultrasound study revealed no evidence of an embryo, and a pattern consistent with a hydatidiform mole. Dilation and curettage was subsequently performed that showed a classic hydatidiform mole on histological examination. Chromosome analysis revealed a normal 46,XX karyotype. DNA was extracted from the placental tissue, as well as maternal and paternal blood. Molecular genetic analysis was performed with four variable number of tandem repeats (VNTR) probes and showed the placental tissue to consist of only paternal DNA with two genomic copies of each allele studied. These findings are consistent with the diagnosis of complete hydatidiform mole and its origin from an empty ovum fertilized by a single sperm. This is the first reported case of a living embryo coexistent with a complete hydatidiform mole documented by genetic analysis.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>complete hydatidiform mole</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>DNA - genetics</subject><subject>DNA - isolation & purification</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hydatidiform Mole - diagnostic imaging</subject><subject>Hydatidiform Mole - genetics</subject><subject>Hydatidiform Mole - pathology</subject><subject>Karyotyping</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Probes</subject><subject>Paternity</subject><subject>placenta</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Ultrasonography, Prenatal</subject><subject>Uterine Neoplasms - diagnostic imaging</subject><subject>Uterine Neoplasms - genetics</subject><subject>Uterine Neoplasms - pathology</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1O6zAQRi0Egt7CIyBlgRB3ERjbsWOvEKr4k5BYAGvLsSfCKKmLnXLp25PSqtu7msV3vpnRIeSUwiUFKq9eACpZKlrXF1r-1VCBLNkemVDBWam4ZvtkskOOyJ-cPwAoFZU4JIdKasUZTAifxX7R4YDF-8rbIfjQxtQXfeyw-BeG98IWLuJ3yAPOhwL7Jq3iMTlobZfxZDun5O3u9nX2UD493z_Obp5Kx5UeSuG9BtcqC5WwDUDDlLSibrzSdUMbaT3zUNcKwTnOmVWt5OCYGIOKW2X5lJxv9i5S_FxiHkwfssOus3OMy2xqxaCWmo2g2IAuxZwTtmaRQm_TylAwa1nmV5ZZmzBaml9ZZt073R5YNj36XWtrZ8zPtrnNznZtsnMX8g7jVEoBfMSuNxiOMr4CJpNdwLlDHxK6wfgY_vPIDxYkhXw</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Baergen, Rebecca N</creator><creator>Kelly, Thomas</creator><creator>McGinniss, Matthew J</creator><creator>Jones, Oliver W</creator><creator>Benirschke, Kurt</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960701</creationdate><title>Complete hydatidiform mole with a coexistent embryo</title><author>Baergen, Rebecca N ; Kelly, Thomas ; McGinniss, Matthew J ; Jones, Oliver W ; Benirschke, Kurt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-5dd90cf8a045ab00b286a57bd897b1b6ad2d0778e0cc332a8f630c256ad43a8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>complete hydatidiform mole</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>DNA - genetics</topic><topic>DNA - isolation & purification</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hydatidiform Mole - diagnostic imaging</topic><topic>Hydatidiform Mole - genetics</topic><topic>Hydatidiform Mole - pathology</topic><topic>Karyotyping</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Probes</topic><topic>Paternity</topic><topic>placenta</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Ultrasonography, Prenatal</topic><topic>Uterine Neoplasms - diagnostic imaging</topic><topic>Uterine Neoplasms - genetics</topic><topic>Uterine Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baergen, Rebecca N</creatorcontrib><creatorcontrib>Kelly, Thomas</creatorcontrib><creatorcontrib>McGinniss, Matthew J</creatorcontrib><creatorcontrib>Jones, Oliver W</creatorcontrib><creatorcontrib>Benirschke, Kurt</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baergen, Rebecca N</au><au>Kelly, Thomas</au><au>McGinniss, Matthew J</au><au>Jones, Oliver W</au><au>Benirschke, Kurt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complete hydatidiform mole with a coexistent embryo</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>27</volume><issue>7</issue><spage>731</spage><epage>734</epage><pages>731-734</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>We describe a case of a complete hydatidiform mole with a coexistent embryo. A 19-year-old Hispanic woman presented with an intrauterine pregnancy at 7 weeks gestational age. An ultrasound evaluation at that time showed a gestational sac and fetal heart activity was observed. Four weeks later, subsequent ultrasound study revealed no evidence of an embryo, and a pattern consistent with a hydatidiform mole. Dilation and curettage was subsequently performed that showed a classic hydatidiform mole on histological examination. Chromosome analysis revealed a normal 46,XX karyotype. DNA was extracted from the placental tissue, as well as maternal and paternal blood. Molecular genetic analysis was performed with four variable number of tandem repeats (VNTR) probes and showed the placental tissue to consist of only paternal DNA with two genomic copies of each allele studied. These findings are consistent with the diagnosis of complete hydatidiform mole and its origin from an empty ovum fertilized by a single sperm. This is the first reported case of a living embryo coexistent with a complete hydatidiform mole documented by genetic analysis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8698320</pmid><doi>10.1016/S0046-8177(96)90406-2</doi><tpages>4</tpages></addata></record> |
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| ispartof | Human pathology, 1996-07, Vol.27 (7), p.731-734 |
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| subjects | Adult Biological and medical sciences complete hydatidiform mole Diseases of mother, fetus and pregnancy DNA - genetics DNA - isolation & purification Female Gynecology. Andrology. Obstetrics Humans Hydatidiform Mole - diagnostic imaging Hydatidiform Mole - genetics Hydatidiform Mole - pathology Karyotyping Male Medical sciences Molecular Probes Paternity placenta Pregnancy Pregnancy. Fetus. Placenta Ultrasonography, Prenatal Uterine Neoplasms - diagnostic imaging Uterine Neoplasms - genetics Uterine Neoplasms - pathology |
| title | Complete hydatidiform mole with a coexistent embryo |
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