Collateral sensitivity to the bisdioxopiperazine dexrazoxane (ICRF-187) in etoposide (VP-16)-resistant human leukemia K562 cells

Etoposide (VP-16)-resistant K562 cells (K/VP.5) were 26-fold resistant to VP-16, due in part to a reduction in DNA topoisomerase II (topoisomerase II) protein levels. Compared with parental K562 cells, VP-16-resistant K/VP.5 cells were found to be 3.4-fold more sensitive to the effects of dexrazoxan...

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Veröffentlicht in:	Biochemical pharmacology 1996-08, Vol.52 (4), p.635-642
Hauptverfasser:	Fattman, Cheryl L., Allan, William P., Hasinoff, Brian B., Yalowich, Jack C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - pharmacology Antineoplastic agents Biological and medical sciences bisdioxopiperazines Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology etoposide Etoposide - pharmacology General aspects Humans ICRF-187 K562 cells Leukemia - drug therapy Medical sciences Pharmacology. Drug treatments Polyenes Pyrones Razoxane - pharmacology Thiobarbiturates - pharmacology topoisomerase II
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