Inflammation in the Uvula Mucosa of Patients With Obstructive Sleep Apnea

This study was conducted to determine whether inflammation is present in the uvula mucosa of patients with obstructive sleep apnea (OSA). Uvulas were obtained by uvulopalatopharyngoplasty in 21 patients with moderate OSA (mean apnea/hypopnea index and standard error of the mean: 32±4) and by autopsy...

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Veröffentlicht in:	The Laryngoscope 1996-08, Vol.106 (8), p.1018-1020
Hauptverfasser:	Sekosan, Marin, Zakkar, Mohamed, Wenig, Barry L., Olopade, Christopher O., Rubinstein, Israel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Edema - pathology Female Humans Inflammation Leukocyte Count Male Medical sciences Middle Aged Mucous Membrane - pathology Non tumoral diseases Otorhinolaryngology. Stomatology Palate, Soft - surgery Pharynx - surgery Plasma Cells Sleep Apnea Syndromes - etiology Sleep Apnea Syndromes - pathology Sleep Apnea Syndromes - surgery Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Uvula - pathology Uvula - surgery
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Zusammenfassung:	This study was conducted to determine whether inflammation is present in the uvula mucosa of patients with obstructive sleep apnea (OSA). Uvulas were obtained by uvulopalatopharyngoplasty in 21 patients with moderate OSA (mean apnea/hypopnea index and standard error of the mean: 32±4) and by autopsy in 5 individuals not known to have OSA. Using point counting in five randomly selected high‐power microscopic fields (×100), the authors found that the number of leukocytes in the lamina propria of the uvula mucosa was significantly higher in patients with OSA than in the controls (179±12 cells vs. 71±4 cells, respectively;P
ISSN:	0023-852X 1531-4995
DOI:	10.1097/00005537-199608000-00021