Aryl 1-But-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as Potential Antipsychotic Agents: Synthesis and Structure−Activity Relationships

A novel series of aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines with dopaminergic activity is described. The structure−activity relationships of this series were studied by synthesis of analogs and evaluation of their affinities for the dopamine (DA) D2 receptor and inhibition of locomotor...

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Veröffentlicht in:	Journal of medicinal chemistry 1996-08, Vol.39 (16), p.3179-3187
Hauptverfasser:	Glase, Shelly A, Akunne, Hyacinth C, Heffner, Thomas G, Jaen, Juan C, MacKenzie, Robert G, Meltzer, Leonard T, Pugsley, Thomas A, Smith, Sarah J, Wise, Lawrence D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemical synthesis Alkynes - pharmacology Animals Antipsychotic Agents - chemical synthesis Antipsychotic Agents - chemistry Antipsychotic Agents - metabolism Antipsychotic Agents - pharmacology Binding, Competitive Biological and medical sciences Brain - drug effects Catecholaminergic system Dopamine - metabolism Dopamine Agents - chemical synthesis Dopamine Agents - chemistry Dopamine Agents - metabolism Dopamine Agents - pharmacology Humans Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Mice Motor Activity - drug effects Neurons - drug effects Neurons - metabolism Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Pyridines - chemical synthesis Pyridines - chemistry Pyridines - metabolism Pyridines - pharmacology Rats Receptors, Dopamine D2 - metabolism Rodentia Saimiri Spiperone - metabolism Structure-Activity Relationship
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