Nitric Oxide: A Mediator of Endotoxin-Induced Middle Ear Effusions

Using a rat model, the authors investigated the role of nitric oxide (NO) in endotoxin‐induced middle ear effusion (MEE). After the eustachian tube was obstructed, the middle ear was transtympanically injected with 35μL of either 1 mg/mL lipopolysaccharide (LPS) or LPS and 1 mmol/L N‐nitro‐L‐arginin...

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Veröffentlicht in:	The Laryngoscope 1996-08, Vol.106 (8), p.1021-1027
Hauptverfasser:	Ball, Steven S., Prazma, Jiri, Dais, C.G. Dean, Rosbe, Kristina W., Pillsbury, Harold C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - analysis Animals Arginine - administration & dosage Arginine - analogs & derivatives Biological and medical sciences Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Enzyme Inhibitors - administration & dosage Enzyme-Linked Immunosorbent Assay Lipopolysaccharides - administration & dosage Medical sciences NG-Nitroarginine Methyl Ester Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Non tumoral diseases Otitis Media with Effusion - drug therapy Otitis Media with Effusion - pathology Otitis Media with Effusion - physiopathology Otorhinolaryngology. Stomatology Rats Time Factors
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