The distribution of human C4 DNA variants in relation to major histocompatibility complex alleles and extended haplotypes
A C4 DNA polymorphism that can subdivide C4 allotypes and major histocompatibility complex-linked complement gene cluster allele combinations (complotypes) that are not distinguishable by standard electrophoretic means was used to assess further the distribution and linkage association of C4 variant...
Gespeichert in:
| Veröffentlicht in: | Human immunology 1988, Vol.21 (1), p.23-32 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 32 |
|---|---|
| container_issue | 1 |
| container_start_page | 23 |
| container_title | Human immunology |
| container_volume | 21 |
| creator | Whitehead, A.S. Truedsson, L. Schneider, P.M. Awdeh, Z.L. Fleischnick, E. Blumenthal, M. Costello, W. Gerald, P.S. Yunis, E.J. Alper, C.A. |
| description | A C4 DNA polymorphism that can subdivide C4 allotypes and major histocompatibility complex-linked complement gene cluster allele combinations (complotypes) that are not distinguishable by standard electrophoretic means was used to assess further the distribution and linkage association of C4 variants. Segregation of the DNA polymorphism in family studies allowed assignment of particular variants to particular major histocompatibility complex haplotypes. These studies revealed that some complotypes were exclusively correlated with a particular C4 DNA variant, whereas others were not and could be subdivided according to which particular C4 DNA variant was observed. When complotypes that could be subdivided at the DNA level were considered in relation to flanking major histocompatibility complex markers, it was apparent that complotypes associated with major histocompatibility complex “extended haplotypes” had an exclusive correlation with a particular C4 DNA variant. This finding supports the hypothesis that “extended haplotypes” are unique associations of major histocompatibility complex allele combinations and are genetically similar, stably inherited units. |
| doi_str_mv | 10.1016/0198-8859(88)90078-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78204523</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>019888598890078X</els_id><sourcerecordid>14953796</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-27de29ac8d4916f38c2e88c7de5a717bc61c4c6f34ed9d946f19300d806c89f93</originalsourceid><addsrcrecordid>eNqFkU9v3CAQxVHVKNmk_QaNxKlqDm7AxhgukaJt_lSK0ksq5YZYGGuJsHEAR9lvHza7yrHlAJp5vzdIbxD6RslPSig_J1SKSohW_hDiTBLSierxE1pQ0cmKUs4_o8UHcoSOU3oiBSIdO0SHDeVNOQu0eVgDti7l6FZzdmHEocfredAjXjL86_4Sv-jo9JgTdiOO4PU7lAMe9FOIeF2swYRhKv2V8y5v8Lby8Iq19-AhYT1aDK8ZRgsWr_XkQ95MkL6gg177BF_37wn6e331sLyt7v7c_F5e3lWmaVmu6s5CLbURlknK-0aYGoQwpdvqjnYrw6lhpggMrLSS8Z7KhhArCDdC9rI5Qd93c6cYnmdIWQ0uGfBejxDmpDpRE9bWzX9BymTbdJIXkO1AE0NKEXo1RTfouFGUqO1q1DZ3tc29XOp9Neqx2E738-fVAPbDtN9F0S92OpQ0XhxElYyD0YB1EUxWNrh_f_AGT7Cf3g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14953796</pqid></control><display><type>article</type><title>The distribution of human C4 DNA variants in relation to major histocompatibility complex alleles and extended haplotypes</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Whitehead, A.S. ; Truedsson, L. ; Schneider, P.M. ; Awdeh, Z.L. ; Fleischnick, E. ; Blumenthal, M. ; Costello, W. ; Gerald, P.S. ; Yunis, E.J. ; Alper, C.A.</creator><creatorcontrib>Whitehead, A.S. ; Truedsson, L. ; Schneider, P.M. ; Awdeh, Z.L. ; Fleischnick, E. ; Blumenthal, M. ; Costello, W. ; Gerald, P.S. ; Yunis, E.J. ; Alper, C.A.</creatorcontrib><description>A C4 DNA polymorphism that can subdivide C4 allotypes and major histocompatibility complex-linked complement gene cluster allele combinations (complotypes) that are not distinguishable by standard electrophoretic means was used to assess further the distribution and linkage association of C4 variants. Segregation of the DNA polymorphism in family studies allowed assignment of particular variants to particular major histocompatibility complex haplotypes. These studies revealed that some complotypes were exclusively correlated with a particular C4 DNA variant, whereas others were not and could be subdivided according to which particular C4 DNA variant was observed. When complotypes that could be subdivided at the DNA level were considered in relation to flanking major histocompatibility complex markers, it was apparent that complotypes associated with major histocompatibility complex “extended haplotypes” had an exclusive correlation with a particular C4 DNA variant. This finding supports the hypothesis that “extended haplotypes” are unique associations of major histocompatibility complex allele combinations and are genetically similar, stably inherited units.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/0198-8859(88)90078-X</identifier><identifier>PMID: 3163333</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alleles ; Boston ; Complement C4 - genetics ; European Continental Ancestry Group ; Genetic Linkage ; Haplotypes ; HLA Antigens - genetics ; HLA-B Antigens ; HLA-D Antigens - genetics ; HLA-DR Antigens - genetics ; Humans ; In Vitro Techniques ; Minnesota ; Polymorphism, Genetic</subject><ispartof>Human immunology, 1988, Vol.21 (1), p.23-32</ispartof><rights>1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-27de29ac8d4916f38c2e88c7de5a717bc61c4c6f34ed9d946f19300d806c89f93</citedby><cites>FETCH-LOGICAL-c354t-27de29ac8d4916f38c2e88c7de5a717bc61c4c6f34ed9d946f19300d806c89f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/019888598890078X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3163333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whitehead, A.S.</creatorcontrib><creatorcontrib>Truedsson, L.</creatorcontrib><creatorcontrib>Schneider, P.M.</creatorcontrib><creatorcontrib>Awdeh, Z.L.</creatorcontrib><creatorcontrib>Fleischnick, E.</creatorcontrib><creatorcontrib>Blumenthal, M.</creatorcontrib><creatorcontrib>Costello, W.</creatorcontrib><creatorcontrib>Gerald, P.S.</creatorcontrib><creatorcontrib>Yunis, E.J.</creatorcontrib><creatorcontrib>Alper, C.A.</creatorcontrib><title>The distribution of human C4 DNA variants in relation to major histocompatibility complex alleles and extended haplotypes</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>A C4 DNA polymorphism that can subdivide C4 allotypes and major histocompatibility complex-linked complement gene cluster allele combinations (complotypes) that are not distinguishable by standard electrophoretic means was used to assess further the distribution and linkage association of C4 variants. Segregation of the DNA polymorphism in family studies allowed assignment of particular variants to particular major histocompatibility complex haplotypes. These studies revealed that some complotypes were exclusively correlated with a particular C4 DNA variant, whereas others were not and could be subdivided according to which particular C4 DNA variant was observed. When complotypes that could be subdivided at the DNA level were considered in relation to flanking major histocompatibility complex markers, it was apparent that complotypes associated with major histocompatibility complex “extended haplotypes” had an exclusive correlation with a particular C4 DNA variant. This finding supports the hypothesis that “extended haplotypes” are unique associations of major histocompatibility complex allele combinations and are genetically similar, stably inherited units.</description><subject>Alleles</subject><subject>Boston</subject><subject>Complement C4 - genetics</subject><subject>European Continental Ancestry Group</subject><subject>Genetic Linkage</subject><subject>Haplotypes</subject><subject>HLA Antigens - genetics</subject><subject>HLA-B Antigens</subject><subject>HLA-D Antigens - genetics</subject><subject>HLA-DR Antigens - genetics</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Minnesota</subject><subject>Polymorphism, Genetic</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v3CAQxVHVKNmk_QaNxKlqDm7AxhgukaJt_lSK0ksq5YZYGGuJsHEAR9lvHza7yrHlAJp5vzdIbxD6RslPSig_J1SKSohW_hDiTBLSierxE1pQ0cmKUs4_o8UHcoSOU3oiBSIdO0SHDeVNOQu0eVgDti7l6FZzdmHEocfredAjXjL86_4Sv-jo9JgTdiOO4PU7lAMe9FOIeF2swYRhKv2V8y5v8Lby8Iq19-AhYT1aDK8ZRgsWr_XkQ95MkL6gg177BF_37wn6e331sLyt7v7c_F5e3lWmaVmu6s5CLbURlknK-0aYGoQwpdvqjnYrw6lhpggMrLSS8Z7KhhArCDdC9rI5Qd93c6cYnmdIWQ0uGfBejxDmpDpRE9bWzX9BymTbdJIXkO1AE0NKEXo1RTfouFGUqO1q1DZ3tc29XOp9Neqx2E738-fVAPbDtN9F0S92OpQ0XhxElYyD0YB1EUxWNrh_f_AGT7Cf3g</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Whitehead, A.S.</creator><creator>Truedsson, L.</creator><creator>Schneider, P.M.</creator><creator>Awdeh, Z.L.</creator><creator>Fleischnick, E.</creator><creator>Blumenthal, M.</creator><creator>Costello, W.</creator><creator>Gerald, P.S.</creator><creator>Yunis, E.J.</creator><creator>Alper, C.A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>The distribution of human C4 DNA variants in relation to major histocompatibility complex alleles and extended haplotypes</title><author>Whitehead, A.S. ; Truedsson, L. ; Schneider, P.M. ; Awdeh, Z.L. ; Fleischnick, E. ; Blumenthal, M. ; Costello, W. ; Gerald, P.S. ; Yunis, E.J. ; Alper, C.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-27de29ac8d4916f38c2e88c7de5a717bc61c4c6f34ed9d946f19300d806c89f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Alleles</topic><topic>Boston</topic><topic>Complement C4 - genetics</topic><topic>European Continental Ancestry Group</topic><topic>Genetic Linkage</topic><topic>Haplotypes</topic><topic>HLA Antigens - genetics</topic><topic>HLA-B Antigens</topic><topic>HLA-D Antigens - genetics</topic><topic>HLA-DR Antigens - genetics</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Minnesota</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whitehead, A.S.</creatorcontrib><creatorcontrib>Truedsson, L.</creatorcontrib><creatorcontrib>Schneider, P.M.</creatorcontrib><creatorcontrib>Awdeh, Z.L.</creatorcontrib><creatorcontrib>Fleischnick, E.</creatorcontrib><creatorcontrib>Blumenthal, M.</creatorcontrib><creatorcontrib>Costello, W.</creatorcontrib><creatorcontrib>Gerald, P.S.</creatorcontrib><creatorcontrib>Yunis, E.J.</creatorcontrib><creatorcontrib>Alper, C.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whitehead, A.S.</au><au>Truedsson, L.</au><au>Schneider, P.M.</au><au>Awdeh, Z.L.</au><au>Fleischnick, E.</au><au>Blumenthal, M.</au><au>Costello, W.</au><au>Gerald, P.S.</au><au>Yunis, E.J.</au><au>Alper, C.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The distribution of human C4 DNA variants in relation to major histocompatibility complex alleles and extended haplotypes</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>1988</date><risdate>1988</risdate><volume>21</volume><issue>1</issue><spage>23</spage><epage>32</epage><pages>23-32</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><abstract>A C4 DNA polymorphism that can subdivide C4 allotypes and major histocompatibility complex-linked complement gene cluster allele combinations (complotypes) that are not distinguishable by standard electrophoretic means was used to assess further the distribution and linkage association of C4 variants. Segregation of the DNA polymorphism in family studies allowed assignment of particular variants to particular major histocompatibility complex haplotypes. These studies revealed that some complotypes were exclusively correlated with a particular C4 DNA variant, whereas others were not and could be subdivided according to which particular C4 DNA variant was observed. When complotypes that could be subdivided at the DNA level were considered in relation to flanking major histocompatibility complex markers, it was apparent that complotypes associated with major histocompatibility complex “extended haplotypes” had an exclusive correlation with a particular C4 DNA variant. This finding supports the hypothesis that “extended haplotypes” are unique associations of major histocompatibility complex allele combinations and are genetically similar, stably inherited units.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3163333</pmid><doi>10.1016/0198-8859(88)90078-X</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0198-8859 |
| ispartof | Human immunology, 1988, Vol.21 (1), p.23-32 |
| issn | 0198-8859 1879-1166 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78204523 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alleles Boston Complement C4 - genetics European Continental Ancestry Group Genetic Linkage Haplotypes HLA Antigens - genetics HLA-B Antigens HLA-D Antigens - genetics HLA-DR Antigens - genetics Humans In Vitro Techniques Minnesota Polymorphism, Genetic |
| title | The distribution of human C4 DNA variants in relation to major histocompatibility complex alleles and extended haplotypes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T18%3A48%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20distribution%20of%20human%20C4%20DNA%20variants%20in%20relation%20to%20major%20histocompatibility%20complex%20alleles%20and%20extended%20haplotypes&rft.jtitle=Human%20immunology&rft.au=Whitehead,%20A.S.&rft.date=1988&rft.volume=21&rft.issue=1&rft.spage=23&rft.epage=32&rft.pages=23-32&rft.issn=0198-8859&rft.eissn=1879-1166&rft_id=info:doi/10.1016/0198-8859(88)90078-X&rft_dat=%3Cproquest_cross%3E14953796%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14953796&rft_id=info:pmid/3163333&rft_els_id=019888598890078X&rfr_iscdi=true |